EMBO’s Post

Dr. Lars Hubatsch from the Hyman lab at the MPI-CBG - Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany is one of our excellent invited speakers at this year's Single Molecule Workshop. At the MPI, he is investigating pattern formation and phase transitions in biological systems. In particular, he studies the internal structure of condensates as well as their assembly dynamics using quantitative imaging and modeling. At the workshop, he will give a talk on "Transport across phase boundaries". Join us for the workshop to learn from Dr. Lars Hubatsch, ask your questions, and discuss your research challenges! October 8-10, 2024, Berlin, Germany ➡️ Registration: https://lnkd.in/dpXy-4A ➡️ Present your own results and submit your abstract by July 24: https://lnkd.in/dpXy-4A Our annual workshop is an interdisciplinary conference that brings together researchers who develop and apply fluorescence microscopy and spectroscopy techniques in life and materials sciences, physics, and chemistry. #molecules #cytoplasm #spectroscopy #microscopy #fluorescence #materialsscience #lifescience

Last week, I had the opportunity to attend the Nencki Conference for Life Sciences, "Focus on Lipid Metabolism," where I presented the results of my research team from the Wydział Mechatroniki Politechnika Warszawska, on our recent advancements in holographic microscopy for life sciences applications. Thank you Nencki Institute of Experimental Biology PAS for the invitation. If you're interested in learning more about our work in Prof. Maciej Trusiak's group, please visit my poster at the ELMI 2024 conference. #optics #photonics #holotomography #cellimaging #opticaldiffractionholography

Happy Birthday Rosalind Franklin Rosalind Franklin was born on July 25, 1920 in London. She contributed to the discovery of the molecular structure of the DNA. The 1962 Nobel Prize in Physiology or Medicine was awarded to Francis Crick, James Watson and Maurice Wilkins, recognizing their work in discovering the structure of DNA. Not included in the Prize was Rosalind Franklin, a scientist whose research made essential contributions to the Nobel Prize winners understanding of DNA. Franklin’s contributions included key images of DNA, taken with these imaging techniques. X-ray crystallography allows analysis of atomic structures not visible with traditional light microscopy. Through these images, Franklin realized that she was seeing two forms of DNA. #icmr #moleculerbiology #biotech #dnabiology #dnastructure

Welcome to read our peer-review entry 📰 Biophysics and Quantum Limitation of Photoreceptive Processes 🖇 https://lnkd.in/gJZNzuGY 📑 This entry paper is an attempt to explain how the discrete nature of light (energy discreteness in the form of photons) constrains the light detection process all along the evolutionary path, in the not-fully-understood photoreceptive systems of unicellular microorganisms (nonimaging systems) and in the complex and well-known visual system of higher organisms (imaging systems). All these systems are perfect examples of the interplay between physics and biology, i.e., they are the perfect topic of research for biophysicists. The paper describes how photoreceptive and visual systems achieve the goal of photon counting, which information is conveyed by a finite number of photons, and which noise factors limit light-detecting processes. ✍ Laura Barsanti, Paolo Gualtieri #rhodopsin #retina #eye #Euglena #gracilis #noise #information

Please join the Workshop"Biophysical Methods for Protein Interactions" in Warsaw

👏 Wow, great achievement! Dr. Andreas Hutzler, team leader at HI ERN, recently received three awards: 🏆 Best Poster Award, Category "Instrumentation & Methodology" 🏆 Best Poster Award, Category "Physical Sciences" 🏆 Best Scientific Image He received the awards at the European Microscopy Congress 2024 EMC2024 in Copenhagen. Well done, Andreas! #EMC2024 # #InSitu #TEM #MEMS #nanotechnology #nanoscience #electronmicroscopy #LPTEM #PEMWE 🔎 Find out more about Andreas, his poster contributions and the awarded scientific image: https://lnkd.in/eVtdPiys

🔬🌱 Delving into the mysteries of life's origins, scientists have made a significant stride by uncovering the atomic structure of an RNA replicase, a key player in the hypothetical "RNA world." In a collaborative effort between the Holliger lab at MRC LMB, Cambridge, UK, and the Andersen lab at Aarhus University, Denmark, the researchers utilized cryogenic electron microscopy (cryo-EM) to reveal the intricate details of this molecular machinery. Published in PNAS, the study focused on an RNA replicase developed by the Holliger lab, specifically designed for efficient copying in the eutectic ice phase, akin to slush-ice. Emil L. Kristoffersen, now an assistant professor at Aarhus University, spearheaded the collaboration, shedding light on the replicase's structure. Remarkably, the unveiled structure exhibits striking similarities to protein-based polymerases, featuring domains for template binding, polymerization, and substrate discrimination arranged in a molecular shape resembling an open hand. 🧤 This discovery not only supports the RNA world hypothesis but also underscores the fascinating connections between ancient RNA mechanisms and their modern protein counterparts.🧬✨

Biophysics is a branch of physics that applies physical principles, approaches or methods in studying or understanding a biological problem. [1] Biophysics is a relatively new science that can be attributed to the success of biophysical tools in revealing the molecular structure of deoxyribonucleic acid (DNA).[2] The basis for the study of biophysics began in the 19th century, by a group of physiologists in Berlin, namely Emil du Bois-Reymond, Ernst von Brücke, Hermann von Helmholtz, and Carl Ludwig. Then in 1982, despite the achievements of these four scientists, Karl Pearson introduced the term "Bio-Physics" in his book entitled The Grammar of Science. The book explains the science that connects biology with physics, or what has become known as biophysics.

My new didactic article entitled "Spin labels and traps. Radicals in the service of science" (Chemia w Szkole, nr 4 (2024), s. 12-17) has just been published. I recommend it to everyone interested in biophysics, chemistry and electron paramagnetic resonance (EPR) spectroscopy. #chemia #chemistry #fizyka #physics #spektroskopia #spectroscopy

Let the research you do make noise! Yesterday, I had the privilege to attend the special guest lecture at Indian Institute of Technology, Delhi by Walter Chazin from the Center for Structural Biology, Vanderbilt University, which left me feeling motivated. 🔶Abstract of the talk: Action at the Replication Fork This lecture delves into the intricate world of DNA replication & repair in eukaryotes. Using cutting-edge cryo-electron microscopy, the dynamic role of the replication fork not only in copying DNA but also in identifying & fixing damage was explored. The research focuses on one fascinating enzyme, pol-prim, responsible for crafting RNA-DNA primers. By analyzing its flexible structure, we reveal how it switches between RNA & DNA synthesis. Additionally, RADX, a protein that regulates DNA repair by limiting the formation of structures, is crucial for mending broken strands. This talk will provide unique insight into how RADX serves as a negative regulator of the formation of RAD51 filaments at stalled and reversed replication forks. Photo credit: Amol Mishra