Farid Hassani’s Post

**Exploring the Realm of Synthetic Bioacoustics: The Intersection of Sound and Biotechnology** Synthetic bioacoustics is a burgeoning field merging acoustic engineering with synthetic biology to create innovative biotechnological solutions. Researchers are leveraging sound waves to manipulate biological processes, such as enhancing gene expression or accelerating biochemical reactions. For example, ultrasonic frequencies can trigger specific cellular responses, potentially revolutionizing drug delivery systems and tissue engineering. This interdisciplinary approach not only paves the way for breakthroughs in medical treatments but also offers novel insights into bio-sound interactions, which may redefine our understanding of biological communication. #SyntheticBioacoustics #Bioengineering #AcousticScience

Happy to share our mini-review that got accepted for publication in the Journal of Nanotheranostics. My first article as a corresponding author 😍 Such a pleasure to publish with my guru Mahesh Narayan, FRSC and my shishya @Daisy Wilson Abstract: The use of carbon nanomaterials including fullerenes, carbon nanotubes, carbon nano- onions, carbon dots and carbon quantum dots for environmental applications has increased substan- tially. These nanoparticles are now used in the development of sensors and switches, in agriculture as smart fertilizers and in the biomedical realm for cancer therapy intervention, as antioxidants, in gene delivery and as theranostics. Here, we review the role of fullerenes as neuroprotectants. Their sp2 hybridized architectures and ability to intervene in the soluble-to-toxic transformation of amyloidogenic trajectories is highlighted here, along with other physico–chemical properties that impact interventional efficacy. Also highlighted are drawbacks that need to be overcome and future prospects.

PI3K enzyme's dual accelerator and brake mechanisms A group of researchers have expanded conventional knowledge on a critical enzyme that controls cell migration. In a recent publication in the journal Nature Communications, they reported that phosphoinositide 3-kinase (PI3K) not only acts as an accelerator to prompt cell motility, but it also has a built-in brake mechanism that impedes migration. Using a combination of bioinformatics, molecular modeling, biochemical binding assays and live-cell imaging, the researchers demonstrated that a disordered region within p85β's inter-SH2 domain directly binds to the endocytic protein AP2. This part of PI3K can activate a cellular process that pulls certain molecules into the cell, and it does so without needing the enzyme's typical lipid-modification function. When the researchers disrupted the binding, the mutated p85β did not function as it should. Instead of regulating cell movement through its brake mechanism, it built up in specific sites within the cell. This leads to cells moving faster and more persistently, indicating a loss of the brake mechanism's control over cell migration. #ScienceMission #sciencenewshighlights https://lnkd.in/gQvUVvzn

Alphafold Search in Choppr (try it out at www.quandlelabs.com) Discover the cutting-edge of molecular biology with AlphaFold, a groundbreaking tool that predicts protein structures with unprecedented accuracy. Developed by DeepMind, AlphaFold harnesses the power of artificial intelligence to forecast the 3D shapes of proteins from their amino acid sequences, revolutionizing our understanding of biological processes. AlphaFold's predictions are based on complex algorithms that analyze protein sequences and their interactions to generate highly accurate 3D models. This technology provides invaluable insights into protein folding and function, paving the way for advancements in drug discovery, disease research, and biotechnology. Start your journey with AlphaFold and unlock the potential of AI-driven protein research! #AlphaFold #ProteinStructure #AIinBioinformatics #DrugDiscovery #MolecularBiology #ResearchInnovation

Here is an example of new research directions that we could explore, thanks to more robust epigenetics data and a deeper understanding of our genome, using the epigenetic capabilities of Oxford Nanopore Technologies.

Little late to post. Thrilled to share that my first review paper from my ongoing Ph.D., Advancing in vivo reprogramming with synthetic biology, has been published this year in Current Opinion in Biotechnology! In this paper, we discuss how synthetic biology is pioneering new ways to reprogram cells in vivo using DNA- and RNA-based tools, offering potential breakthroughs in precision medicine and cell therapy. Feel free to give it a read and share it with colleagues who may be interested in this latest perspective! #SyntheticBiology #InVivoReprogramming #CellTherapy #PhDResearch #PrecisionMedicine #FutureOfHealthcare https://lnkd.in/gWGam7Y6

Revolution in DNA synthesis. If you haven't heard, Ansabio is making long DNA enzymatically, unlike other players on the market, such as Twist or IDT. That is a game changer for long and/or complex sequences. Why is it important? Because what we see in nature and the human genome is almost always complex and long. High GC, high AT, repetitive, secondary structure, you name it. And Ansabio is doing it with a snap of a finger, 1kb overnight, megabases in a week, high fidelity. Enzymes are just so much better! And that's just the beginning. What's going to happen to Twist over time? PS: RNA and antisense therapeutics are going to change forever too: you won't need to wrestle with stereochemistry when enzymes do it for you. #syntheticbiology #dna #genetherapy https://lnkd.in/g8VUDUa3

Proteomics is an emerging field with capabilities to advance our understanding of biology, disease and identify new drug targets. High throughput methods even have the ability to predict drug response ahead of trials and can be used complimentary to genomics and traditional MS studies. Important factors to consider when looking at the most appropriate technology in this field for your studies are: Is it specific/reproducible? Is it easily scalable for further expansion? Is it translatable to the clinic? Can you easily compare data between studies years apart? What do you think - Is Proteomics the next big Ome?

MunichImaging scientists Ajay Kesharwani & Vipul Gujrati shed light on the multimodal techniques and strategies for #chemical and #metabolic #imaging at the single-cell level, their advantages, limitations, and outlook in this review. Read in Current Opinion in Biotechnology Elsevier https://lnkd.in/dUzPq2cQ #singlecell #fluorescence #optoacoustic #photoacoustic #omics #spectrometry #raman Helmholtz Munich Technical University of Munich

Unlock the potential of advanced spatial transcriptomics and proteomics! We offer a comprehensive solution for spatial profiling using NanoString Technologies, Inc.'s GeoMx® platform. 👩🔬Effortless Process: Just provide your samples and select a panel. We handle everything else. 🧬In-Depth Profiling: Delve into the entire transcriptome or over 570 protein targets across various sample types. 🎯Precise ROI Strategies: Rooted in tissue morphology, our approach ensures accurate profiling of your chosen compartments or cell groups. Empower your research 👉https://bit.ly/3S8Mtr4 #SpatialTranscriptomics #Proteomics #Transcriptomics #OMICS #Bioscience #Biotech