Nature Medicine speaks with our CEO Ashley Zehnder about what we’re working on at Fauna Bio.
“With the obesity market booming, the next generation of weight loss drugs might come from unlocking the secrets of hibernation, when animals gain (and then lose) up to 40% of their weight, with hopes that hibernation-powered drugs can modify metabolism and boost health.
When the thirteen-lined ground squirrels emerge in spring, they do not show any negative consequences, such as wasted muscles, brittle bones or bedsores. Similarly, their blood vessels lack clots, and they show no signs of ischemia or reperfusion injuries. From a biomedical perspective, hibernation is a near-miraculous feat, aspects of which could potentially be mimicked in humans through new therapeutics.
This is the goal of a team of scientists at Bay Area’s Fauna Bio, who have been working to crack the code of hibernation in thirteen-lined ground squirrels and other species. Their goal is to understand the molecular and genetic underpinnings not just of hibernation but also the myriad adaptations that underpin an animal’s ability to survive a range of extreme conditions.
Work at Fauna caught the eye of execs at pharma giant eli Lilly, who paid US$494 million for access to Fauna’s Convergence database in december 2023. This database of comparative physiology overlays maps of human genes and disease pathways with the equivalent physi- ological pathways in animals with extreme phenotypes. “We’re bringing fully new data- sets to drug discovery,” says Ashley Zehnder, co-founder and chief executive officer of Fauna Bio.”
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