How do you study interactions between small molecules and membrane proteins? Subtle mass changes between the ligand-free and bound states of membrane proteins can present a challenge. However, using FIDA's hydrodynamic radius measurement (absolute size) and BRIC signal (Binding Related Intensity Change) is an easy, label-free and in-solution approach to tackle the problem. Read more in our new poster by Emil https://lnkd.in/dsGqqRNP #membranes #smallmolecules #smallmolecule
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Learn about Bio-Rad's PTC Tempo 48/48 and PTC Tempo 384 Thermal Cyclers: https://ow.ly/NKlm50RwZ7K The 48/48 format offers enhanced functionality for multi‑user labs with its two independent heating blocks. The 384 accelerates sample throughput for labs with high-volume testing needs. Explore the PTC Tempo today. #Genomics #Biotechnology
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Learn about Bio-Rad's PTC Tempo 48/48 and PTC Tempo 384 Thermal Cyclers: https://lnkd.in/gwVzKyQF The 48/48 format offers enhanced functionality for multi‑user labs with its two independent heating blocks. The 384 accelerates sample throughput for labs with high-volume testing needs. Explore the PTC Tempo today. #Genomics #Biotechnology
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📢[New Publication! – Optimizing #AAVPurification using the High-Throughput and Automated Crossflow System] 🧬Adeno-associated viral (AAV) vectors have become well-established tools in #genetherapy, driving the demand for faster and more efficient #AAV manufacturing. One critical step in #AAVmanufacturing is the ultrafiltration and/or diafiltration (UF/DF) during #downstreamprocessing, which typically requires substantial amounts of feeding material (i.e. AAV) and time for effective optimization. ⌛ To address this, researchers from iBET - Instituto de Biologia Experimental e Tecnológica and Sartorius, used the Ambr® Crossflow system for high-throughput, automated screening of multiple UF/DF parameters in one single run. Key highlights: ➡️Different membrane materials (PES and Hydrosart), pore sizes (30 and 100 kDa) and process conditions were investigated. ✅Best performer: 100kDa PES flat sheet cassette achieved the best overall performance. ✅Scalable performance: This cassette demonstrated similar AAV8 recovery, permeate flux and total protein removal to small-scale devices, and outperformed the hollow fibre option when scaled to a larger system. 💪The Ambr® Crossflow allowed to efficiently test various UF/DF parameters, making it a powerful accelerator for developing efficient AAV downstream processing. Learn more 🔗https://lnkd.in/gWRHJJix Congratulations to the authors! 👏 Sónia Mendes Tiago Faria André Nascimento Marc Noverraz Dr. Franziska Bollmann, PMP Piergiuseppe Nestola, PhD Antonio Roldao Cristina Peixoto Ricardo Silva #AAV #downstream #genetherapy #bioprocessing #tff
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Bioquochem (BQC redox technologies) will participate in the upcoming IUFOST2024ITALY (September 8-12, 2024 | Rimini, Italy). We are excited to announce that Sara Menéndez Cotarelo will be delivering an insightful talk on Bioactive Compound Rapid Screening (#BRS): A Versatile and Promising #Analytical Technique for #Quantifying #Bioactive #Compounds in Diverse #Hydrophilic and #Lipophilic Matrices. On September 10th, there is a brief discussion in the exhibition area, and then we will delve deeper into the topic during the session on september 12th. 📍Speech | September 12: 10/11 am in Borgo Room 📍BOOTH 52 #Key points to be covered: Overview of Bioactive Compound Screening Applications in hydrophilic and lipophilic matrices Advantages of BRS over traditional methods Case studies and practical examples and on-site #BRS demos. See you there!
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Heading to ESHG this week? Katie Poulter and Rebecca Howard from our Omics Team are excited to discuss: ✅accelerating your Omics tool development ✅biochemistry and automation ✅and overcoming technical and commercial barriers Connect with our experts to learn more, we hope to see you there! #ESHG #omicstools
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What role does NFDI play for different disciplines? Our series continues with Stefanie Weidtkamp-Peters of NFDI4BIOIMAGE. ℹ NFDI4BIOIMAGE works on building an infrastructure of bioimaging data and supporting researchers in handling, storing, reusing and sharing data. 💡 More about NFDI4BIOIMAGE: https://lnkd.in/eB3VFQrv ℹ Learn more about the NFDI consortia https://lnkd.in/ejvBb7mu #fdm #rdm #nfdi #bioimaging #researchdata
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New research 🔬 is shedding light on an understudied environmental mycobacteria. Congratulations to Ji Won Lee, Won-Ho Kim, Jong Seok Kim, and their team, for the important paper investigating the immune responses and metabolic reprogramming associated with nontuberculous Mycobacterium peregrinum. Read the full paper 📝 and discover how the team used Axion’s next-generation Maestro Z live-cell analyzer to assess cell viability in real time with no labels, dyes, or complicated steps. 🔗https://bit.ly/49nWarU #livecellanalysis #cellviability #cytotoxicity #biotech
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Uncover the shared roles of PDZ and LIM domain (PDLIM) proteins in metazoan actin function. Dive into structural insights with Michael Healy and Brett Collins in this enlightening mini-review. #BiochemSocTrans. https://lnkd.in/ee_C7-zG
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An effective screening tool for #Metabolomics and #DrugDiscovery workflows, this library now provides access to over 95,000 natural products. With expanded compound coverage and addition of 17K IR and 41K CNMR computed spectra. Learn more https://ow.ly/fVKK50RhVso #Wiley #NaturalProducts
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Accelerating drug discovery & development by improving screening workflows with libraries and structure drawing tools…that is the simple but important objective of this great product release. #naturalcompounds #activecompounds #drugdiscovery #chemicalstructure
An effective screening tool for #Metabolomics and #DrugDiscovery workflows, this library now provides access to over 95,000 natural products. With expanded compound coverage and addition of 17K IR and 41K CNMR computed spectra. Learn more https://ow.ly/TmTt50RhVlR #Wiley #NaturalProducts
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