Yokogawa Fluence Analytics’ Post

ARGEN is specifically tailored for the rapid characterization and assessment of the stability and viability of therapeutic #biopolymers such as #proteins, peptides, nucleic acids, polysaccharides, viral vectors, LNP-mRNA vaccines, and bioconjugates. It addresses the common issue of aggregation that occurs when biopolymers deviate from their native states under various stress conditions like thermal, chemical, or mechanical stress. Click here to download the eBook today to learn more about how ARGEN can expedite formulation development efforts and for case studies on thermal, chemical, and mechanical stability, interfacial behavior, and material interactions. #RNA #rnatherapeutics #biotech https://lnkd.in/gBsfvyUD

Aggregation typically occurs when #biopolymers deviate from native states under thermal, chemical, or mechanical stress conditions. ARGEN was designed for the rapid characterization and assessment of the stability and viability of therapeutic biopolymers. These include #proteins, #peptides, nucleic acids, polysaccharides, viral vectors, LNP-mRNA vaccines, and bioconjugates. Download our eBook today to learn how to expedite your formulation development efforts with thermal, chemical, and mechanical stability, interfacial, and material interaction studies, all in one instrument. #DNA #RNA #biotech https://lnkd.in/gBsfvyUD

Using ARGEN, #biopharma teams can evaluate the reactions of their #biologics to various forms of mechanical, thermal and chemical stress. This unique capability of ARGEN allows teams to model stressors #biopharmaceuticals will encounter during #bioprocessing and throughout the #biologic life cycle, providing a comprehensive stability landscape for formula optimization. Discover more insights in the Advancing Therapeutic Biopolymer Development eBook today. #biotech #protein #peptide #biotherapeutics https://lnkd.in/gBsfvyUD

What do #hyaluronicacid (#HA), hydroxypropyl methylcellulose (#HPMC) and #gelatin have in common? They are all food and medical grade polymers whose processing is controlled by solution viscosity, IV. Wait, I thought it was Molecular Weight? #Nope. Check it out at PubMed: https://lnkd.in/gPbw6UBB Hyaluronic acid has an enormous range of grades, based on Molecular Weight. Ask any different industry expert and you'll get different answers. But our Hot Take is this: anywhere from 25kDa to 25,000kDa is out there on the market. How is that molecular weight measured? You can run #GPC on the small stuff, but you can get that result with a higher degree of precision and 10x faster by using Dilute Solution Viscosity. For those larger samples with extremely high molecular weights, there's absolutely no GPC or even FFF system that is going to give you accurate results. Too much chance of material adhering to all that surface area of your system. A typical Hyaluronic Acid sample with IV = 5-8 dL/g runs at about 0.05-0.1% w/v. With a 20mL preparation, that is 10-20mg. Low MW (i.e. low IV) requires more sample. Expected IVs around 2.0 dL/g we run at about 0.2% w/v. How much sample do you use as a general rule? Take the inverse of the expected Intrinsic Viscosity and you have your maximum target concentration. Ideally, use 50% less than that maximum. Standard methods from ASTM, ISO and EN show this to be a straightforward, easy-to-run technique. High MW samples with IVs up to 10, even 20 dL/g can be rapidly analyzed Haiku Instruments automates the sample preparation, dissolution, and analysis. Weigh out your sample, set it in the autosampler, and walk away. The HaikuFlow software does the rest. With built-in LIMS outputs, you can feed the data right into your quality system. Concerned about Compliance? System suitability checks can run with every sample sequence, confirming the data quality. User access levels ensure that the right method is run every time, no matter the operator. Need #audit support? Have a custom reporting requirement that we have not mentioned? DSM Lifecore Biomedical Contipro Kewpie Fine Chemical

Note: We cannot buy time, but we can save time! No time-consuming tasks like LC system & column passivation required! Choose our groundbreaking MaxPeak HPS Technology, featuring an innovated surface hardware construction with our High Performance Surface (HPS) Technology, eliminating broad peaks or analyte loss due to non-specific adsorption from traditional stainless steel hardware contact surfaces. This innovation provides chromatographers with a decisive edge in managing challenging analytes with "broad peaks" and "sticky" characteristics. MaxPeak HPS Columns are most suited for electron-rich compounds that are metal-sensitive, such as analytes rich in Phosphate and Carboxylate groups. #WatersCorporation #MaxPeakPremierColumns #ACQUITYPremierLC #ARCPremierLC #QbD #Chromatography

𝗣𝗿𝗲𝗰𝗶𝘀𝗶𝗼𝗻 𝗘𝗻𝗴𝗶𝗻𝗲𝗲𝗿𝗶𝗻𝗴 𝗼𝗳 𝗟𝗶𝗽𝗶𝗱-𝗕𝗮𝘀𝗲𝗱 𝗡𝗮𝗻𝗼𝘀𝘆𝘀𝘁𝗲𝗺𝘀 𝘃𝗶𝗮 𝗜𝗺𝗽𝗶𝗻𝗴𝗲𝗺𝗲𝗻𝘁 𝗝𝗲𝘁 𝗠𝗶𝘅𝗶𝗻𝗴 by Manuel Zettl; Carolin Tetyczka; C. Glader; Ramona Jeitler; S. Stephan; M. Segl; Y. Wang; Philippe Caisse; Vanessa Bourgeaux; M. Spoerk; Eva Roblegg; Johannes Khinast, Flash nanoprecipitation and emulsification by solvent diffusion, also known as the ‘emulsification by the ouzo effect’, are multi-component reactions commonly employed for large-scale production of drug-loaded lipid-based nanocarriers. In these processes, product properties and uniformity depend on effective mixing of various components under controlled conditions. In impingement jet mixers (IJMs), this is achieved by two fluid jets consisting of a water-miscible organic solvent and an anti-solvent colliding at a specific angle within a predefined geometry [1,2]. We studied the scalability of this process to higher throughputs while maintaining nanocarrier size and specific flow regimes.

Interested in prodrugs? An excellent review which analyses approved prodrugs and discusses trends in their development, design rationales, indications, mechanisms of API release, chemistry of promoieties and market impact. A complete package. https://lnkd.in/gawr_jF9

Have you registered for our webinar today? If not, there is still time! Join Peter Pellegrinelli, Applications Specialist, as he presents alongside The Chinese American Chromatography Association (CACA) on A New Column Chemistry for Improved Separation of Basic Compounds. To register, click below. We'll see you at noon! #CACA #AdvancedMaterialsTechnology #halocolumns #webinar

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Nice article - have a look. This article outlines critical factors in long-term stability of proteins, and how different stabilizers protect against mechanical and thermal stress. #proteins #proteinformulation #proteinaggregation