FluidicMEMS’ Post

🌟 New Customer Case Study: Research in Cancer Spheroid Modeling 🌟 👩🔬 Rahman, Z. et al., at Delft University of Technology, have unveiled a groundbreaking cancer model using microfluidics. They showed the involvement of tumor microenvironment in cancer progression, underscoring its importance for future research. 🧬 Their innovative approach includes a 3D-matrix embedding lung cancer spheroids, mimicking tumor microenvironment conditions such as interstitial flow and TGF-β cytokines in a microfluidic chip. 🔬 With Fluigent’s pressure pump, MFCS series, they achieved precise and stable pressure, paving the way for reproducible results. Discover how this technology sheds light on the use of mechanotransduction and cytokines in cancer cell invasion 🔍 Learn more about the study: https://bit.ly/43HLEdc #Microfluidics #CancerResearch #Innovation #Research

scientists from the Karolinska Institutet in Sweden have developed tiny robots, or nanorobots, capable of specifically targeting and killing cancer cells. These nanorobots activate the cells' 'death receptors' to help shrink tumors. The innovative approach, known as DNA origami, uses DNA and peptides to create a kill switch that only activates in the slightly acidic environment around tumors. Lab tests have shown promising results, with breast cancer tumors in mice shrinking by up to 70%. This revolutionary technology marks a significant step forward in cancer treatment, aiming to minimize side effects and enhance precision in targeting cancer cells. #CancerResearch #MedicalBreakthrough #Nanotechnology #HealthInnovation #DNAOrigami #CancerTreatment #MedicalScience #TechNews

A DNA Origami Nanoswitch to Induce Cancer Cell Death Folding DNA into intricate structures has produced intriguing basic research for a while now. Today, I saw a really neat application in the field of cancer therapy: When properly exposed to specific cells, the death receptor 5 cluster induces cell death.  Björn Högberg and colleagues designed a nanometer-sized pH-switch using the transition from double-stranded DNA to triple-stranded DNA to either hide or expose the death receptor 5 ligand cluster. The pH change was induced in a tumor microenvironment, and this forced the nanoswitch to expose its ligands, killing tumor cells. The technology is at an early stage and has yet to overcome many hurdles. Still, I will keep it on my radar for future medical nanorobots. https://lnkd.in/e5xs8q5X Yang Wang, Igor Baars, Ieva Berzina, Iris Rocamonde-Lago, Boxuan Shen, Yunshi Yang, Marco Lolaico, Janine Waldvogel, Ioanna Smyrlaki, Keying Zhu, Robert A. Harris, Björn Högberg #DNAorigami #nanorobots #nanoswitches #cancertherapy www.zumbuehl-lipids.com

A mini-colon models colon cancer and its microenvironment Current organoid models for colon cancer have several shortcomings and do not represent full extent of the disease. The researchers used tissue-engineering and microfabrication technologies to develop topobiologically complex, patient-specifc cancer avatars. They generated miniature tissues consisting of long-lived gut-shaped human colon epithelia (‘mini-colons’) that stably integrate cancer cells and their native tumor microenvironment in a format optimized for real-time, high-resolution evaluation of cellular dynamics. They demonstrate the potential of this system through several cancer related applications and could be applicate for several cancer types. #sciencenewshighlights #ScienceMission https://lnkd.in/gRHZQUtF https://lnkd.in/gfCJAf2f

The relationship between #cancer and senescence is complex, but #proteomics work like this could enable us to leverage it to better treat malignancy. Thanks to Jennifer Tsang, Ph.D. for help with this post!

What is the link between senescence — a cellular state during which cells stop dividing — and cancer? By studying their complex relationship, researchers are uncovering both positive and negative outcomes associated with senescent cells. In our new blog post covering applications of #proteomics in cancer research, we discuss work from Scott Lowe's lab at Memorial Sloan Kettering Cancer Center showing how senescent cells can interact with the immune system to promote tumor clearance. Check it out to learn about these key interactions and how they might be leveraged to develop more effective cancer therapies. https://ow.ly/gRtu50SCyvk #UnleashTheProteome #ProteomicsRevolution #SingleMolecule #MassSpec #TeamMassSpec #Biotech #Cancer

New from Cell Chemical Biology: Arc Core Investigator and Stanford University Biochem Professor Lingyin Li explores the future of cancer therapy using cGAMP-STING 🧬 The Li lab works to investigate how the signaling molecule cGAMP is passed between different cell types to activate the STING pathway and how cancers escape detection through cGAMP degradation — which controls how immune cells are recruited to a tumor to fight cancer. The perspective piece from Dr. Li outlines the successes + setbacks of cGAMP analogs as STING agonists, as well as new strategies for boosting endogenous cGAMP-STING signaling for cancer therapy while avoiding toxic side effects.👇 https://lnkd.in/gaaD2ZME

🔊Today we share the #Article "Radiogenomic System for Non-Invasive Identification of Multiple Actionable Mutations and PD-L1 Expression in Non-Small Cell Lung Cancer Based on CT Images" 👥by Jun Shao, Jiechao Ma, et al. Sichuan University Access the full paper here➡️ https://lnkd.in/dhSNz_BG Keywords: actionable mutations; non-small cell lung cancer; deep learning

✍️"New review highlighting recent advances in basic and translational/clinical research on CTCs as key elements in the metastatic cascade." Metastasis is the leading cause of cancer-related deaths. Most studies have focused on the primary tumor or on overt metastatic lesions, leaving a significant knowledge gap concerning blood-borne cancer cell dissemination, a major step in the metastatic cascade. Circulating tumor cells (CTCs) in the blood of patients with solid cancer can now be enumerated and investigated at the molecular level, giving unexpected information on the biology of the metastatic cascade. 📕Good reading !!!! https://lnkd.in/ez4nYUSj European Liquid Biopsy Society (ELBS) LCCRH - Laboratoire Cellules Circulantes Rares Humaines CHU de Montpellier #cancer #liquidbiopsy #CTC 🩸💉#precisionmedicine #circulatingtumorcells Zahra Eslami-S, Luis Enrique C., Klaus Pantel

Invadopodia are highly dynamic cellular structures that emerge from the basal side of cancer cells. These structures possess an F-actin-based core. In this acquisition, I managed to capture the sprouting of an invadopodium precursor structure. The video presented is a maximum intensity projection through the coronal (XZ) plane of the cancer cell, which allows visualization of growth in z-direction. We can observe 'clouds' of LifeAct-tagged F-actin structures migrating through the plasma membrane before coalescing into a protrusion. This acquisition was performed using spinning disk confocal microscopy on head and neck cancer cells expressing LifeAct-mCherry to visualize F-actin.