Fox Chase Cancer Center’s Post

A naturally occurring mutation in T cells that leads to lymphoma can be weaponized to make engineered T-cell therapies more effective against cancer, including melanoma, findings from a new study in mice suggest. #oncology #cancer #tcell #celltherapy #lymphoma #melanoma #leukemia #cancerresearch #clinicalresearch

What is #LiquidBiopsy?? It is the question many people (not working in this industry have asked me..? It is not a new frontier. HOWEVER, what is new is that it is indeed a changed landscape and researchers have dramatically impacted this area of medicine providing for an easier and better way to test for disease/cancer and or if a therapeutic is working and more! Precision Medicine- Bench to Bedside, check out the latest advancements in Small Cell Lung Cancer Detection!

Researchers in the Sahin Lab have found that targeting the protein TACC3 can restore the effectiveness of the breast cancer drug T-DM1. “These findings represent a key advancement in overcoming drug resistance in HER2-positive breast cancer,” write post-docs Emre Gedik and Ozge Saatci. Learn how MUSC Hollings Cancer Center is changing what's possible in cancer research: https://lnkd.in/eQXDXXde #ChangingWhatsPossible

Ubiquitous pyrogens and 3D cancer models A recent study has highlighted the impact of endotoxins on the accuracy of three-dimensional (3D) cancer models. In this Q&A, Dr Bjorn Vergauwen, Scientific Director for Product and Process Development at Rousselot, reveals details and key findings of the research. #cancer #3Dmodels #endotoxins

[IEP X INSIGHT] Macrophage-targeted cancer therapies Part 1. As research continues to reveal the impact of the tumor microenvironment (TME) on cancer treatment, approaches that focus on altering the TME, rather than directly targeting the tumor itself, are emerging as effective strategies for cancer therapy. In this article, we will explore the relationship between macrophages, a key component of the TME, and cancer treatment. Please click the link to visit our webpage and read the full article! https://lnkd.in/gnQ3JguM

Leveraging #ADCs in Lung Cancer: Snapshot of Existing Challenges and Opportunities 👇 OncLive discuss research efforts dedicated to leveraging antibody-drug conjugates with varying targets in lung cancer. Click the link below to read the article 🔗 https://lnkd.in/eFj-nKPS

I have written my first Editorial Commentary which has been published in Translational Lung Cancer Research (TLCR), https://lnkd.in/dz6Sh9kN. Here, we discuss the findings by Sivapalan et al., Clinical Cancer Research 2023, where they use liquid biopsies and targeted sequencing to stratify patients with small cell lung cancer. While more research is waranted, I believe this and similar studies, demonstrate how liquid biopsy dynamics could play a crucial role for these patients in the future. Give it a look!

During a presentation at the 2024 American Association for Cancer Research, Dr. Andrew Vickers, a biostatistician at Memorial Sloan Kettering Cancer Center(MSK), sought to raise awareness about the best way to use the PSA test for prostate cancer screening. Here, Dr. Vickers, an expert in health outcomes related to the detection and treatment of prostate cancer, provides a recap of common myths about PSA tests and prostate cancer screening: https://bit.ly/3Jeiskq #AACR24

Combining tissue and liquid biopsy improves cancer care by detecting mutations more effectively, especially for cases like breast cancer. The study with 3,209 ethnically diverse patients affirms the clinical utility of using both liquid biopsy and tissue samples in identifying actionable variants among patients with advanced cancer. Click here to read more: https://bit.ly/47RroWS #liquidbiopsy #nextgenerationsequencing #venturecapital #privateequity #deerbornedifference