Fractyl Health’s Post

✨ 𝗡𝗼𝗱𝗧𝗵𝗲𝗿𝗮'𝘀 𝗖𝗹𝗶𝗻𝗶𝗰𝗮𝗹-𝘀𝘁𝗮𝗴𝗲 𝗠𝗲𝗱𝗶𝗰𝗮𝘁𝗶𝗼𝗻 𝗦𝗵𝗼𝘄𝘀 𝗣𝗿𝗼𝗺𝗶𝘀𝗲 𝗖𝗼𝗺𝗽𝗮𝗿𝗮𝗯𝗹𝗲 𝘁𝗼 𝗪𝗲𝗴𝗼𝘃𝘆 𝗳𝗼𝗿 𝗪𝗲𝗶𝗴𝗵𝘁 𝗟𝗼𝘀𝘀 𝗶𝗻 𝗣𝗮𝗿𝗸𝗶𝗻𝘀𝗼𝗻'𝘀 𝗗𝗶𝘀𝗲𝗮𝘀𝗲! 🌐 𝗜𝗻 𝗙𝗲𝗯𝗿𝘂𝗮𝗿𝘆 𝟮𝟬𝟮𝟰, the Flagship clinical-stage #medication from NodThera for #Parkinson's illness is nearly as good as Novo Nordisk's Wegovy at causing weight reduction. NodThera directly compared its #medications NT-0796 and NT-0249 to Wegovy in a Journal of Richmond Pharmacology and Experimental Therapeutics Centre (ETC) paper published on February 19. The study also examined the effects of calorie restriction in obese mice 🐁. NT-0249 decreased inflammatory #biomarkers 🧬 linked to #heartdisease , whereas NT-0796 lowered weight loss almost as quickly as #wegovy . According to these results, #brainpenetrant NLRP3 suppression and the ensuing #antiinflammatory action provide Metabolic advantages that go well beyond obesity reversal in obese mice fed a high-fat diet. stated in a news statement by Alan Watt, CEO of NodThera.   𝗕𝗿𝗼𝘄𝘀𝗲 𝗮𝘁 𝗼𝘂𝗿 𝗟𝗶𝗻𝗸𝗲𝗱 𝗥𝗲𝗽𝗼𝗿𝘁 👉: https://bit.ly/3UQ9gtM #Parkinson’s #Drugmaker #Biomarkers #Suppressor #prophecymarketinsights

Here, researchers present a significant advancement in understanding the structure and function of GPR61, an orphan #GPCR associated with appetite-related phenotypes. Until now, the lack of structural information and a known biological ligand or tool compound has posed challenges in studying GPR61 comprehensively. This research has the potential to pave the way for the development of novel therapeutic strategies targeting disorders of metabolism and body weight, such as obesity and cachexia. #GPCR #DrugDiscovery

Source: International journal of biological sciences IL-33 is a key inflammatory factor in chronic atrophic gastritis (CAG) and is induced by H. pylori and MNNG through the ROS-STAT3 signaling pathway. IL-33 enhances autophagy in gastric epithelial cells through the AMPK-ULK1 axis, and inhibiting autophagy alleviates CAG severity. IL-33 also promotes GKN1 degradation through the autolysosomal pathway. IL-33 and GKN1 in serum show potential as diagnostic markers, and targeting the IL-33-AMPK-ULK1 pathway could be a therapeutic strategy for CAG.

Congratulation to Dr. Priyankar Dey’s team on their recent research investigating the cellular mechanisms underlying the hepatoprotective effects of Nerium oleander. Their study revealed how oleander mitigates endotoxin-induced damage to hepatocytes. By using an in vivo model to test anti-inflammatory and metabolic health benefits, followed by evaluating oleander's impact on LPS-treated HepG2 cells, they provided strong evidence of oleander's hepatoprotective effects. In this study, HepG2 cell counting was performed using our automated cell counter, FACSCOPE® B. We are grateful for FACSCOPE® B being part of the research. To read the full article: https://lnkd.in/gMf3JAu9 More information about FACSCOPE® B: https://lnkd.in/gQ6SBw-H #cellcounting #FACSCOPE #Curiosis #HepG2 #LPM #oxidative #Nrf2 

𝗠𝗼𝗹𝗲𝗰𝘂𝗹𝗮𝗿 𝗺𝗲𝗰𝗵𝗮𝗻𝗶𝘀𝗺𝘀 𝗼𝗳 𝘀𝘁𝗮𝘁𝗶𝗻-𝗿𝗲𝗹𝗮𝘁𝗲𝗱 𝗮𝗱𝘃𝗲𝗿𝘀𝗲 𝗲𝗳𝗳𝗲𝗰𝘁𝘀 Statins are generally very safe, but a small minority of patients face side effects that can lead to discontinuation of therapy. Muscle-related side affects (Statin Associated Muscle Symptoms, SAMS) are relatively common but poorly understood on a mechanistic basis. This metabolomics changes adds to our knowledge. The authors conclude that changes in pro-inflammatory lipids and mitochondrial metabolism are key contributors to SAMS. This understanding may pave the way to better management of this side effect to this staple class of therapeutics that has attracted interest for its potential well beyond cardiometabolic diseases. https://lnkd.in/dYDRfaE3 Full citation: Garrett TJ, Puchowicz MA, Park EA, Dong Q, Farage G, Childress R, et al. (2023) Effect of statin treatment on metabolites, lipids and prostanoids in patients with Statin Associated Muscle Symptoms (SAMS). PLoS ONE 18(12): e0294498. https://lnkd.in/dX7cAY_y. Freely available under a Creative Commons license: https://lnkd.in/dATi2mun #science #metabolism #precisionmedicine #phermacology

Increased catalytic activity of the enzyme alcohol dehydrogenase (adh-1) is linked to extended lifespan & longevity of C. elegans through the degradation of glycerol, and glyceraldehyde, 2 major byproducts of lipid metabolism. Another enzyme with promising translational and therapeutic implications. https://lnkd.in/eMmyy4_k

All the new therapies for migraine are here!! A complete overview of migraine treatment!

The ongoing surge in #diabetes emphasizes the urgent need for #innovation. Beyond technological advancements, there is promise in gene therapy, regenerative medicine, machine learning, and more for diabetes care. Projections show the advanced diabetes care devices market reaching $33.4 billion by 2030. Read more about the latest research report: https://hubs.la/Q0273QxF0. #DiabetesAwareness #HealthTech #Research #Investing #Investment #Business #Markets

Source: Phytomedicine : international journal of phytotherapy and phytopharmacology Co-catalpol can alleviate fluoxetine-induced liver injury by inhibiting ferroptosis through ATF3/FSP1 signaling. This study provides insights into the detoxification mechanism and efficacy of co-catalpol in combination with fluoxetine for depression therapy. PMID: 38401490 | DOI: 10.1016/j.phymed.2024.155340

Check out our new article where we explored how ( +)-Lipoic acid (ALA) affects inflammation and oxidative stress within an in vitro model. This model utilized HepG2 cells treated with palmitic acid and oleic acid to induce steatosis. https://lnkd.in/d7-_CjH7