Frederick Luzzio’s Post

We are happy to share our joint paper with Prof. Tibor Soós: "Strain-Release-Driven Modular Synthesis of Oxetane-Based Amide Bioisosteres: Concise, Robust and Scalable Approach," co-authored by Enamine scientists: Yarema Galushchak and Pavel Mykhailiuk. This study presents a practical, scalable method for constructing oxetane-containing amide bioisosteres, using the enhanced reactivity of oxetan-3-one. The method simplifies the synthesis of previously challenging derivatives, demonstrating significant potential in medicinal chemistry. Read more: https://lnkd.in/dh9H_qra Browse and purchase our products at EnamineStore: https://lnkd.in/diy7GrH5

Extended application of Benzotriazole. Here it acts as a leaving group.

Don't miss our recent interview with Shuli You from Shanghai Institute of Organic Chemistry,CAS where we discussed his recent Communication, "Rh(iii)-catalyzed atroposelective C–H alkynylation of 1-aryl isoquinolines with hypervalent iodine–alkyne reagents", now published in our special 60th anniversary collection! Read the full interview on our blog 👉 https://lnkd.in/evc4VdVp And read Shuli's full communication here 👉 https://lnkd.in/e8RZsKQU Q - What is your favourite thing about ChemComm? A - I am very impressed with the rapid publication process, which allows scientists to share their exciting findings promptly with the scientific community. Q - Could you provide a brief summary of your recent ChemComm publication? A - The C-H alkynylation of 1-aryl isoquinolines with hypervalent iodine-alkyne reagents was realized in the presence of chiral cyclopentadienyl-Rh(III) complex, providing axially chiral alkynylated 1-aryl isoquinolines in excellent yields and enantioselectivity.

Though it's late, but nevertheless, I'm thrilled to announce the publication of research article from my Master's dissertation, titled as "Macrocyclic Sulfur Ligand Stabilized Trans-Palladium Dichloride Complex: Syntheses, Structure, Chlorine Rotation, and Application in α-Olefination of Nitriles by Primary Alcohols" in Chemistry-An Asian Journal. This work was made possible with the invaluable guidance and support of my guide, and mentor Dr. Hemant Joshi.  The article explores the development of a macrocyclic sulfur ligand-stabilized trans-palladium dichloride molecular rotor and its application in the α-olefination of nitriles using primary alcohols. This innovative approach has the potential to enable the synthesis of a variety of α,β-unsaturated nitrile-containing molecules, which are of great interest in medicinal and therapeutic applications. This publication is a testament to the collaborative efforts and the dedication of my mentors and research team. Please feel free to reach out if you have any questions or would like to discuss the article further. Do read the article at : https://lnkd.in/gtAbgP8R #Chemistry #Catalysis #Research #Publication

Here, we report a short route for synthesis of pharmaceutical important compounds

What an innovative approach to harnessing the potential of isocyanides in drug discovery! This method not only simplifies synthesis but also opens up exciting avenues for creating novel pharmacophores. Kudos to the team for pushing the boundaries of medicinal chemistry! 👏 #DrugDiscovery #DrugDevelopment #MedicinalChemistry #Innovation #SharingUsefulContent

14th International Chemistry Congress event, slated for, October 31-November 01, 2024 at Amsterdam, Netherlands. "The main theme of the conference is “Frontiers of Discovery: Pushing Boundaries in Chemical Research" #Eurochemistry #Eurochemistry2024 #Organicchemistry #Inorganicchemistry #Computationalchemistry #Biochemistry #Medicinal chemistry

🔬 Revolutionizing Chemistry: Harnessing the Potential of Phosphine Ligands! Phosphine ligands have emerged as indispensable tools in catalysis, materials science, and drug discovery, revolutionizing the landscape of chemistry. These versatile compounds offer unparalleled opportunities for innovation, enabling the development of novel synthetic methodologies and advanced materials with tailored properties. Join the conversation to delve into the fascinating world of phosphine ligands and explore their transformative impact on scientific research and technological advancement.🌟#PhosphineLigands #ChemicalInnovation #Catalysis #MaterialsScience #DrugDiscovery #ScientificResearch https://lnkd.in/gnE6hTUz

Our group is committed to demonstrating the potential of the isocyanide as an emerging pharmacophoric group. To achieve this, we have developed a method to easily synthesize novel scaffolds containing an isocyano moiety in a single step, utilizing Ugi and Passerini multicomponent reactions. By exploiting the different nucleophilic behaviors of aromatic, aliphatic, and benzylic isocyanides, we have successfully achieved our goal! Explore our latest publication on The Journal of Organic Chemistry to witness this method in action. Additionally, we have demonstrated that it is possible to conduct these reactions with three different isocyanides in the same flask, where only one reacted, yielding valuable diisocyanides in medicinal chemistry. Gian Cesare Tron Mariateresa Giustiniano https://lnkd.in/dk_zc8Fq

The introduction of the cyclopropyl fragment into a lead compound can enhance potency, increase metabolic stability, improve binding to the target, and reduce off-target effects. Cyclopropanes with multiple stereocenters provide rigidity while also increasing three-dimensionality. These two properties make them ideal fragments to explore new areas of chemical space in medicinal chemistry. This convenient method of organocatalytic decarboxylative borylation of cyclopropane redox-active (NHPI) esters was described in a recently published paper by Oleksandr Grygorenko et al. (https://lnkd.in/dc8mCGHv) Explore our cyclopropanecarboxilic acids for your research! https://lnkd.in/di3Smuzt