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🦠 Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), is one of the world's deadliest infectious diseases and remains a global health threat, killing over a million people each year. Urgent efforts in research and treatment are crucial to combat this ancient yet persistent pathogen. Ondřej Bulvas from Iva Pichova Group along with Tomáš Kouba Group from IOCB Prague have described a new mechanism of inhibition of IMPDH from Mycobacteria, which opens a new way to developing of antimycotical drugs. The detailed mechanisms and results of this research were published in the journal Nature Communications. See more ► https://lnkd.in/dBgdHbbk ⤵️ 📓 Original study: Bulvas, O.; Knejzlík, Z.; Sýs, J.; Filimoněnko, A.; Čížková, M.; Clarová, K.; Rejman, D.; Kouba, T.; Pichová, I. Deciphering the allosteric regulation of mycobacterial inosine-5′-monophosphate dehydrogenase. Nat. Commun. 2024, 15, 6673. DOI: 10.1038/s41467-024-50933-6 ⤵️

'The authors reviewed the needs or gaps as perceived by stakeholders of disease vector control programs in eleven countries and subnational states in South Asia and the Middle East. Programs for control and elimination of malaria, dengue and leishmaniases had major shortcomings in vector surveillance and entomological capacity. This was a concern because vectors develop insecticide resistance which, if unchecked, could reduce the effectiveness of interventions. Also, attaining elimination of disease demands enhanced vector surveillance support. There were major gaps in community mobilization and intersectoral collaboration. The findings imply that vector control systems should adapt to the changing disease situation and adopt a cross-disease mandate. The authors propose improvements to the methods of needs assessment.'

World Tuberculosis Day ! Data Analyst Felicitate🌍 Today marks World Tuberculosis Day, and what better way to celebrate than by diving into the world of data analysis! As part of this ongoing project, let's continue our work by exploring insights from the tuberculosis world database. Our data team is dedicated to unraveling the mysteries of tuberculosis, shedding light on its global impact and potential solutions. With love for data analytics and a shared commitment to our fellow Homo sapiens, let's harness the power of data to make a difference. What is Tuberculosis? Tuberculosis, often referred to as TB, is a highly contagious bacterial infection caused by Mycobacterium tuberculosis. It primarily affects the lungs but can also target other parts of the body, leading to symptoms such as coughing, chest pain, fever, and fatigue. Causes of Tuberculosis: Tuberculosis spreads through the air when an infected person coughs, sneezes, or talks, releasing droplets containing the bacteria. Factors such as weakened immune systems, overcrowded living conditions, and close contact with infected individuals increase the risk of contracting TB. Prevention of Tuberculosis: Preventing tuberculosis involves a multifaceted approach, including vaccination, early detection, and treatment. The Bacillus Calmette-Guérin (BCG) vaccine is widely used to protect against TB, especially in regions with high prevalence. Additionally, practicing good respiratory hygiene, maintaining a healthy lifestyle, and ensuring prompt diagnosis and treatment of TB cases are crucial preventive measures. Let's continue our journey of data exploration and analysis, striving to combat tuberculosis and improve the health and well-being of people worldwide. Together, let's spread awareness, advocate for action, and work towards a TB-free future. #WorldTBDay #DataAnalysis #TBawareness #OneLoveDataTeam 📊❤️

Towards surmounting the burden of multidrug-resistant tuberculosis and malaria in Africa, scientists from the West African sub-region have proffered new ways of tackling the diseases, with emphasis on the deployment of artificial intelligence as the most accurate method of diagnosing tuberculosis.

Alhamdullah, I 'm honoured and pleased to share with you our Article on " A Late Diagnosis of Visceral Leishmaniasis Using Tru-Cut Biopsy of the Spleen and Malaria Co-Infection – A Diagnostic Challenge: A Case Report in Somalia " which we were published recently in Infectious and Drug Resistance , SCOPUS indexed Journal. The case highlights the importance of Visceral leishmaniasis (VL) is a challenging disease to diagnose, especially in areas where it coexists with other infectious diseases, such as malaria. A high index of suspicion is necessary for the timely diagnosis of VL, and a tru­cut biopsy of the spleen can be conducted in cases where other investigations are inconclusive in endemic areas. Early diagnosis and prompt treatment of visceral leishmaniasis are crucial to prevent complications and reduce mortality Click on the link below to read and download the full article. https://lnkd.in/earQaizb Dr. Sumait Hospital SIMAD University

Pertinent ... Cell immunity and correlates of protection... CD4 T cell response is dominated by Type 1 regulatory cells during malaria which share signatures with Th1 cells. CD4 T cells play multiple essential roles in protection from malaria, including IFNγ mediated direct killing of parasites, and by providing help to B cells to produce antibodies required for protection

Immune response in people from malaria-endemic regions of Ghana, exposed to Plasmodium falciparum and positive for SARS-CoV-2 Ghana and other parts of West Africa have experienced lower mortality rates for COVID-19 and a higher asymptomatic spread than other regions. It was hypothesized that previous exposure to Plasmodium parasites, which cause malaria, could indirectly protect against severe forms of infection with the SARS-CoV-2. Importantly, a previous study employing an integrative approach to evaluate the molecular similarity of antigenic sites predicted in the SARS-CoV-2 RBD with proteins/antigens from other different organisms has shown a molecular similarity between the antigenic sites of the S protein RBD and 54 antigenic determinants in fifteen pathogens, including Plasmodium falciparum and Plasmodium knowlesi. The author of this study stated that individuals who have previously been infected with or immunized against malaria, tuberculosis, or other diseases caused by fifteen microorganisms with molecular similarity between their antigenic determinants and SARS-CoV-2 RBD, are expected to display a substantial degree of resistance against infection with SARS-CoV-2. The findings of this study suggest that modulation of immune response to SARS-CoV-2 after exposure to Plasmodium falciparum may contribute to reduced severity of COVID-19 among people living in malaria-endemic regions. #malaria #SARSCoV2 #COVID https://lnkd.in/eqDwmM6d

World Tuberculosis Day, observed annually on March 24th, is a pivotal moment for raising awareness about tuberculosis (TB) – a global health concern that affects millions worldwide. This year's theme, 'Yes! We Can End TB This day serves as a reminder of the ongoing efforts to combat TB and the need for continued action to eradicate this infectious disease. Tuberculosis is caused by a bacteria called Mycobacterium tuberculosis. It primarily spreads through the air when an infected person coughs, sneezes, or talks, releasing infectious droplets. Close and prolonged contact with an infected individual increases the risk of transmission. Through awareness campaigns, educational initiatives, and healthcare interventions, the day aims to emphasize the importance of early detection, access to quality care, and research for innovative solutions. With millions affected worldwide, World Tuberculosis Day underscores the need for continued collaboration among governments, healthcare professionals, researchers, and communities to eradicate TB and ensure a healthier future for all.

Exposure to Plasmodium falciparum may modulate immune response to SARS-CoV-2 and contribute to reduced severity of COVID-19 among people living in malaria-endemic regions. In this study, the authors from Ghana and Germany investigated the immune response in people from malaria-endemic regions of Ghana, exposed to Plasmodium falciparum, the most common malarial pathogen in West Africa, and positive for SARS-CoV-2. Interestingly, in his study from 2021, Dakal TC (link in comments) discovered that SARS-CoV-2 RBD had molecular similarity with antigenic determinants from Plasmodium falciparum (8 antigenic determinants). He stated two interesting things. 1. individuals previously infected with or immunized against malaria (or other diseases caused by fifteen microorganisms with molecular similarities between their antigenic determinants and SARS-CoV-2 RBD), are expected to display a considerable degree of resistance against SARS-CoV-2 infection. and 2. over-representation of antigenic determinants from Plasmodium falciparum suggests that antimalarial drugs can be clinically beneficial for COVID-19 treatment.

According to the World Health Organisation (WHO), malaria🦟is endemic to 84 countries, with 247 million estimated cases in 2021. 👉In this blog, we talk about breath VOC analysis as an innovation to fight infectious diseases, with a deep dive into the malaria parasite. Read the blog: https://ow.ly/4ZCN50TrKIE We are particularly grateful to the Bill & Melinda Gates Foundation👐 for supporting us with grant funding to develop VOC biomarkers of malaria. This research includes the potential for developing low-cost diagnostics to improve malaria testing in vulnerable or lower resource communities. Read more about the Gates funding here: https://ow.ly/btVp50TrKMS #malaria #voc #diagnosis #breathtest