Are you attending #AAFP2024? 🐱 Stop by booth 308 and let’s discuss the future of feline care! Discover how the ready-to-use stem cell therapies Gallant is developing is setting a new standard of medicine targeting the underlying disease pathology for devastating conditions like feline chronic gingivostomatitis, feline chronic kidney disease and feline osteoarthritis. Join the new revolution caring for your feline patients. Cheers to the next generation of therapy and cats living their best lives. 🐾 🥂 #FelineCare #StemCellsInVet #VetInnovation #FelineHealth #StemCellInnovation #VeterinaryMedicine Clinical trials in progress: https://lnkd.in/eHUa2Nnu
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Today is #NationalDNADay! #DidYouKnow Genetics play a big role in your oral condition? You may be predisposed to dental cavities, periodontal disease or oral cancer. The best thing you can do is get checked up regularly by your dentist! If you aren't sure, ask your family about their oral health and continue to take good care of your mouth! #dna #genetics #dentalhealth #oralhealth #denverdentist
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Polygenic risk score testing in #glaucoma and #eyecare is starting to gain traction. From screening to understanding the risk of development to advanced disease, the applications are endless. Check out this piece from Rich Carriero on how PRS testing works, some of the latest research on glaucoma #genetics and why it all might help push patient outcomes in your clinic sooner than you think. https://lnkd.in/gYu2ZaUa
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This is a fabulous review detailing the strategies for modulating programmed cell death mechanisms in the context of disease. Thanks to Joshua Webster from #GenentechResearchPathology for his contributions and to his co-authors Nobuhiko Kayagaki and Kim Newton from #GenentechPhysiologicalChemistry. #genentech #pathology
Control of Cell Death in Health and Disease
annualreviews.org
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💜 Community Talks: Karina 💜 💥 When diagnosis don't justify all symptoms “Daniel had 4 brain surgeries after his diagnosis of Moyamoya in 2001. He was having blood clots and we were advised to have the revascularization surgery so the brain could get better blood flow. Back then, the neurosurgeon who operated on Daniel said to us that Daniel’s MRI didn’t show a typical Moyamoya image. We had to wait 6-7 years to finally get the diagnosis of Multisystemic Smooth Muscle Dysfunction Syndrome (MSMDS). I felt relief with MSMDS including all of Daniel’s symptoms that Moyamoya couldn’t explain. Daniel was one of the firsts to be diagnosed with MSMDS and at that time not much was known about the disease. But it gave me reassurance that the doctors could now keep a close eye on Daniel and compare the results with other patients they could have so all of us together could gain greater knowledge in this disease.” 🧠 MSMDS or Moyamoya? Patients affected by MSMDS with Moyamoya-like disease present a lack of basal collateral vessels and abnormally straight cerebral vessels. Patients with MSMDS have an increased risk of perioperative stroke and usually suffer issues when anaesthesia or sedation are required in medical procedures. 🙌 Understanding MSMDS MSMDS is an incurable multisystemic disease affecting the brain, blood vessels, heart, aorta, lungs, liver, kidneys, bladder, eyes, and other body parts with smooth muscle cells. There are only 60 diagnosed patients worldwide, mostly children. 💚 The Hope of Gene Therapy Gene therapy research in Boston offers hope for MSMDS patients. With your support, we can bring life-changing treatments to those affected by this ultra-rare disease. https://lnkd.in/edkSR9Cy #ActByAct #MSMDS #GeneTherapy #MSMDSAwarenessDay #PatientStory #RareDiseaseAwareness #Moyamoya #moyamoyadisease #MoyamoyaAwareness #Revascularization #brainsurgery #brainsurgerysurvivor #genetherapy
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Our August issue is live! *REVIEW Mitochondrial function and gastrointestinal disease *REVIEW Endogenous ethanol production in health and disease *CONSENSUS STATEMENT Fibrostenosing small bowel Crohn's disease *PERSPECTIVE AI in liver cancer ...and much more. Check it out: https://lnkd.in/et3CMeVK #viralhepatitis #Crohnsdisease #IBD #livercancer #mitochondria #gastroenterology #hepatology
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In a worlds first, doctors successfully performed the first transplant of a genetically modified pig kidney into a living human, giving hope to those in need of #organtransplants The recipient has been in the transplant program for 11 years. Previously received a kidney in 2018. Resumed dialysis with end-stage kidney disease in 2023. What was required to get here? 1. #CRISPR - 69 precise edits to the pig’s DNA to deactivate pig retroviruses that can reawaken and infect humans. 2. #Monoclonal antibodies - specifically tailored to prevent the rejection of pig organs. 3. Tests and protocols - assured safety and saved a life. #medtech #healthcareinnovation
US surgeons transplant a gene-edited pig kidney into a patient for the first time
apnews.com
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A great article by the experts in the field with regards to the Diagnosis and Management of Inherited Retinal Diseases. Unlike typical textbook chapters in IRDs this article includes the viewpoint of a patient expert. This is a great way to inform clinicians in understanding the lived experience of patients, the unmet needs and outcomes that are meaningful to patients. I think, it is the way to go, and I hope that more and more authors include patient perspectives going forward. https://lnkd.in/eXPQTDD2 #inheritedretinaldiseases #dystrophies #retina #diagnosis #management #irds #innovation #genetics #gene #therapy #optometry #ophthalmology #retina #eye #disorders #degenerations #inherited
Fundamentals of the Diagnosis and Management of Inherited Retinal Diseases - Retina Today
retinatoday.com
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"Messenger RNA are the biggest regulators of pro-inflammatory gene expression, so we developed a strategy to target them.” - Ceria founder, Dr. Ken Liechty Read more about our research in a microRNA known as miR146a, a regulator of immune function: #ARDS | #lunghealth | #pulmonology
Stopping the Vicious Cycle of ARDS
childrenscolorado.org
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A scientist interested in translating life science skills into solving real life problems relating to microbes, aging, neurodegenerative and metabolic diseases. An advocate of inclusive science and life style changes.
Here is another study supporting the involvement of microbes in pathophysiology of neurodegenerative diseases, especially the sporadic form of the diseases. In this study, the authors reported that nasal infection with Saccharomyces cerevisiae (S. cerevisiae) in α-syn A53T transgenic mice accelerates the aggregation of α-syn. Further more, they discovered that injection of Sup35 fibrils, a yeast prion protein into the striatum of wild-type mice led to α-syn pathology and PD-like motor impairment. #dementia #neurodegenerativediseases #parkinsonsdisease #microorganisms Link to the study:
The yeast prion protein Sup35 initiates α-synuclein pathology in mouse models of Parkinson’s disease
science.org
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Great to see the PD field moving towards a biological definition of the disease as we recently have in AD. Putting the emphasis on biomarkers should improve rates of early detection and accurate diagnosis.
A published paper from patient, research, and industry leaders proposed a new staging system by which Parkinson disease (PD) is defined, using neuronal α-synuclein (n-αsyn) pathology, considered a hallmark for the disease, instead of clinical symptoms. Otherwise known as the neuronal α-synuclein disease integrated staging system (NSD-ISS), this system is currently intended for research use only, with the goal to enhance trial design and improve drug development. THE MICHAEL J FOX FOUNDATION FOR PARKINSON https://lnkd.in/eVCf7ECn
International Working Group Proposes New Framework for Defining Parkinson Disease Based on Biology, Not Symptoms
neurologylive.com
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Member National Academy of Medicine, Experienced Administrator, and UC Davis Distinguished Professor
1wCongratulations on the development of these amazing new stem cell products! Gallant Therapeutics and Linda Black, DVM, PhD