Garuda Therapeutics’ Post

🌟 Register now for our upcoming webinar: "From the Lab to the Bench: Scaling up Regulatory T Cell Therapy."   Register here: https://lnkd.in/gbYgfq5e   🗓️ Date: Thursday, September 12th, 2024 🕗 Time: 11:00 EDT Join us to hear from Megan Levings, Ph.D., from the University of British Columbia and the BC Children's Hospital Research Institute, who will present compelling data on how CAR-engineered Tregs can induce immune tolerance. This breakthrough has significant implications for the treatment of autoimmune diseases, organ transplants, and stem cell transplantation. The discussion will also cover the importance of producing these therapeutics in a closed, automated environment to minimize contamination risks and human error. Don't miss out on this opportunity! #Webinar #RegulatoryTCellTherapy #Immunology #Autoimmune

Not every patient responds to drugs in the same way 💊 . This may be due to differences in DNA. The structure of genes in DNA can make certain drugs work faster or slower. This is why geneticists are now creating a profile that can be used to determine exactly what patients' expected sensitivity is to certain medication. It will become available to our haematology patients this month. In cancer treatments such as stem cell therapy or CAR-T cell therapy, incorrect starting doses can have consequences. Haematologist 👩⚕️ Carolien Woolthuis expects a lot from the DNA profile: ‘It shows which dosage best suits the patient. That can make all the difference.' 👍 Geneticists Jackie Dekens and Lude Franke will investigate whether it can also be applied to patients with other conditions, such as cardiovascular disease. They will also investigate whether healthy individuals can also benefit. 'We want to know whether all the information is clear and whether participants also want to share it with their healthcare providers. And we would like to investigate whether it makes sense to make such a DNA profile of everyone.' Curious to find out more? ➡ https://lnkd.in/eTQpj--Q #haematology, #dna #lifelines

A good example of MPAL (t/myeloid) W/ BCL11B deregulation Think of this entity when U see t/myeloid leukemia w/ FLT3 and/or WT1 mut Unlike ETP, these are strongly & diffusely positive for BCL11B by IHC @BloodJournal #Hemepath #leusm #FLT3

📍 Interpreting single-cell messages in normal and aberrant hematopoiesis Busarello et al. developed the Cell Marker Accordion, a user-friendly platform for the automatic annotation and biological interpretation of single-cell populations based on consistency weighted markers. Key points 📌 Validation on peripheral blood and bone marrow single-cell datasets 📌 Improved the accuracy in identifying cell types 📌 Identification of disease-critical cells, pathological processes and potential biomarkers 📌 Comprehensive characterization of acute myeloid leukemia, multiple myeloma and myelodysplastic syndrome. ➡ More details: https://lnkd.in/e2AAyKMN #UniversityofTrento #spatialomics #spatialbiology #singlecellanalysis #singlecell

https://lnkd.in/gnezZtAu Article title: Dissemine intravasculary coagulation may be the presenting feature for chronic myelomonocytic leukemia: Special case report   Author(s): Itir Sirinoglu Demiriz   Journal: Archives of Hematology Case Reports and Reviews   Journal ISSN: 2640-7914 Abstract: Chronic myelomonocytic leukemia (CMML) is a malignant myeloid stem cell disease accompanied by dysplasia in the context of myeloproliferative disease. Peripheral cytopenias (mainly anemia and thrombocytopenia) and hepatosplenomegaly are common findings. Dramatic leukocytosis can also be seen without transformation to acute myeloid leukemia (AML); in some cases, this leukocytosis is associated with leukostasis and end organ damage. Splenomegaly is present in up to 25 percent of patients with CMML and is often accompanied by hepatomegaly, lymphadenopathy, or nodular cutaneous leukemic infiltrates. #Anemia #AcuteMyeloidLeukemia #LymphAngiogenesis #HematologicalMalignancies #BloodTransfusion #SerumProteinElectrophoresis #HematopoieticStemCellTransplantation #PhotoAcoustics #LymphNodeBiopsy #BCellLymphoma #InvivoFlowCytometry #ChainsofHemoglobin #Lymphoma #HodgkinsLymphoma #Coagulation #Thalassemia #NonHodgkinsDisease #MultipleMyeloma #StemCellsAndHematopoiesis #LeukocytesAndPlatelets #RedCellBiology #HematologicNeoplasia #Immunobiology #BloodAndMarrowTransplantation #TransfusionMedicine #VascularBiology #Hemobiology #Peertechz #PeertechzPublications #OpenAccess #ScientificJournals #PeerReviewedJournals #OpenAccessPublishers

https://lnkd.in/gWF24DKZ Article title: Chronic myelomonocytic leukemia: A rare hematologic malignancy that needs due consideration   Author(s): Temesgen Assefa*; Yosef Alebel   Journal: Archives of Hematology Case Reports and Reviews   Journal ISSN: 2640-7914 Introduction: Chronic Myelomonocytic Leukemia (CMML) is a malignant hematopoietic stem cell disorder with clinical and pathological features of both a myeloproliferative neoplasm and myelodysplastic syndrome [1]. According to the 2016 WHO classification of hematologic malignancies it is categorized as MyeloDysplastic /Myeloproliferative Neoplasm [2]. CMML is a rare aggressive Chronic Leukemia with a tendency to progress to Acute Leukemia.It occurs most commonly in older adults, with a median age at diagnosis is ~ 65–75 years. There is a moderate male predominance in its incidence [3]. #MyelodysplasticSyndrome #MyeloproliferativeNeoplasm #Leukocytosis #Monocytosis #Anemia #AcuteMyeloidLeukemia #LymphAngiogenesis #HematologicalMalignancies #BloodTransfusion #SerumProteinElectrophoresis #HematopoieticStemCellTransplantation #PhotoAcoustics #LymphNodeBiopsy #BCellLymphoma #InvivoFlowCytometry #ChainsofHemoglobin #Lymphoma #HodgkinsLymphoma #Coagulation #Thalassemia #NonHodgkinsDisease #MultipleMyeloma #StemCellsAndHematopoiesis #LeukocytesAndPlatelets #RedCellBiology #HematologicNeoplasia #Immunobiology #BloodAndMarrowTransplantation #TransfusionMedicine #VascularBiology #Hemobiology #Peertechz #PeertechzPublications #OpenAccess #ScientificJournals #PeerReviewedJournals #OpenAccessPublishers

Summary: The article explores the development of mRNA‐engineered CD5‐CAR‐γδTCD5‐ cells for immunotherapy in T-cell acute lymphoblastic leukemia. Using nanobodies and CRISPR/Cas9 technology, CD5‐CAR‐γδTCD5‐ cells demonstrate potent antitumor efficacy against malignant T-cell lines, showcasing a promising approach in CAR-T therapy. Hashtags: #immunotherapy #mRNAengineering #CAR-T #biohacking #leukemiatreatment Read more here: https://lnkd.in/dBbPYkca BioMedHack.com is your leading source for the latest news, breakthroughs, and insights in medicine, biohacking, and alternative medicine. Our mission is to help you live healthier and longer by bringing you cutting-edge information and expert advice. Follow us on Facebook, Instagram, and X.

🔊 Weekly round-up!   🧫 Advancing regenerative cell therapy development In an interview with Alder Therapeutics, we discuss regenerative cell therapy development and explore an approach in pluripotent stem cell therapy development which expedites the delivery of transformative therapies.     🧪New biomarkers found for diabetic kidney disease Researchers from Shanghai Institute of Materia Medica and Xinhua Hospital found biomarkers through urinary and exosome proteome profiling that have potential for diagnosis and disease monitoring.   🧫 Targets for pancreatic cancer treatment found   Using tumour organoids, researchers at Weill Cornell Medicine have found a starting point for the development of a more refined PDAC drug.   🧪Potential of precision diagnostics for gestational diabetes mellitus Rutgers School of Public Health researchers highlight the need for a more nuanced diagnostic approach, examining whether nonglycemic markers could refine risk stratification.   Click on the links in the comments to read more! 👇   #drugdiscovery #lifescience #drugtargets 

"The latest issue of Cell J (February 2024) has been published." It covers various topics:   ·Phosgene Toxicity Clinical Manifestations and Treatment: A Systematic Review ·Review on Kidney-Liver Crosstalk: Pathophysiology of Their Disorders Resveratrol Nanoformulation Inhibits Invasive Breast Cancer Cell Growth through Autophagy ·Induction: An In Vitro Study Simultaneous Coating of Electrospun Nanofibers with Bioactive Molecules for Stem Cell ·Osteogenesis In Vitro Bioinformatics-Guided Discovery of miRNAs Involved in Apoptosis Modulated by Parthenolide ·Combined with Vincristine in The NALM6 Cell Line ·        CTLA-4 Blockade of Natural Killer Cells Increases Cytotoxicity against Acute Lymphoid Leukaemia Cells ·Atorvastatin’s Therapeutic Potential in Atherosclerosis: Inhibiting TGF-β-Induced Proteoglycan Glycosaminoglycan Chain Elongation through ROS-ERK1/2-Smad2L Signaling Pathway Modulation in Vascular Smooth Muscle Cells   For more information, please visit the journal’s website (www.celljournal.org). #melatonin #mouse #sperm #stemcells #oxidativestress #mitochondria #osteoblastic #differentiation #tissueengineering #metabolic #brain #cholesterol #adipose #alzheimers #spinalcord #injury #blood #invivo #protein #male #drug #animal #ovariancancer