Global Business Reports (GBR)’s Post

Do not miss this webinar today at 1600 CET by Thomas Finnie (Head of Modelling and Data-Science for Emergency Preparedness, Resilience, and Response UK Health Security Agency). Blurb: All viral pathogens mutate, sometimes that mutation has profound effects on how the pathogen affects the human population (for example by evading the human immune system), often it does not. In this talk I will explore how we have begun to bring together the multiple scales of understanding required to turn raw genomic, or virological information into modelling the effects on a population so that public health actions may be taken. https://lnkd.in/gCT7zana

#Health | 𝗜𝗻𝗳𝗹𝘂𝗲𝗻𝘇𝗮 𝗩𝗶𝗿𝘂𝘀𝗲𝘀 𝗖𝗮𝗻 𝗨𝘀𝗲 𝗧𝘄𝗼 𝗪𝗮𝘆𝘀 𝘁𝗼 𝗜𝗻𝗳𝗲𝗰𝘁 𝗖𝗲𝗹𝗹𝘀 | An international research team led by Associate Professor Dr. Silke Stertz from the Institute of Medical Virology at the University of Zurich has found that certain human and avian influenza viruses can utilize a second entry pathway to infect cells, beyond the known pathways on the cells' surface. Through meticulous research using lab-grown cell lines and human airway cultures, the team uncovered that the hemagglutinin protein on the influenza virus surface also binds to MHC class II protein complexes on immune and respiratory cells. This pivotal finding reveals how influenza viruses can adapt to use alternative entry pathways, potentially affecting their ability to infect different species and jump between animals and humans. Understanding this mechanism is crucial for developing strategies to combat interspecies transmission of influenza. 👉 Learn more >> https://lnkd.in/gcH4Sz2f 👉 Original publication >> https://lnkd.in/gaWYCjzC Image: iStock/tawatchaiprakobkit 🇨🇭 Follow #ScienceSwitzerland for the latest news and emerging trends on Swiss science, technology, education, and innovation >> www.swissinnovation.org Follow us >> Science-Switzerland #Science | #Education | #Research | #Innovation

#COVID19 has become endemic, with dynamics that reflect waning immunity and ongoing transmission, compared to the earlier epidemic phase when it spread throughout immunologically naïve populations. This CoVaRR-Net funded paper in preprint (therefore not peer-reviewed) by our Computational Analysis, Modelling and Evolutionary Outcomes (#CAMEO) Pillar Co-Lead Sarah Otto and professor at The University of British Columbia, and Deputy Caroline Colijn, professor at Simon Fraser University, states that while SARS-CoV-2 continues to evolve, behavioural shifts and public health policies continue to play a role in the endemic load of disease and death. Their study analyzes evolutionary models and reveals that variants with persistent immune-escape pose the greatest threat to increasing the endemic load, followed by more transmissible variants. The paper explores strategies, including vaccination and non-pharmaceutical interventions, to counteract the rising disease impact caused by evolving variants. Read more here: https://ow.ly/qrOa50QAeRe

Dengue, yellow fever, Zika, and West Nile viruses persist as major threats to global public health, affecting millions annually and claiming hundreds of thousands of lives. Recognizing the urgency of effective interventions, the FLAVIVACCINE project seeks to offer an innovative, safe, and effective vaccine by developing and characterizing a pan-flavivirus vaccine candidate. We are proud to contribute our expertise and be a partner in this important project! Check out this video describing the threat and groundbreaking work being done to develop a safe and effective vaccine. #InfectiousDiseases #Vaccine #Research #MedicalResearch #Flavivaccine

🔆What is Disease X? ✅Recently, the World Health Organisation (WHO) emphasised the urgent need for global preparedness against a potential new pandemic, referred to as 'Disease X'. ✅It is referred to as a hypothetical pathogen or threat that can cause a major pandemic in future. ✅It could be a new agent, a virus, a bacterium, or a fungus without any known treatment. ✅The term coined by scientists and the World Health Organization could be any of the 25 families of viruses that have the capability to cause illness in people. ✅Disease X was included in the WHO’s updated Blueprint list of diseases back in 2018. ✅Scientists are of the opinion that Disease X could be 20 times more deadly than SARS-Covid virus that caused pandemic recently. ✅It represents an illness which is currently unknown but could pose a serious microbial threat to humans in the future. #upscprelims2024 #upscexam #biotechnology #genetics

Our new open access research provides a potential mechanism to explain how sub-lethal doses of neonicotinoids impair the immune function of pollinators https://lnkd.in/eMBPWWXe

New research from Dave Goulson et al. on the impact of neonicotinoid pesticides on honeybees: "There is growing concern that some managed and wild insect pollinator populations are in decline, potentially threatening biodiversity and sustainable food production on a global scale. In recent years, there has been increasing evidence that sub-lethal exposure to neurotoxic, neonicotinoid pesticides can negatively affect pollinator immunocompetence and could amplify the effects of diseases, likely contributing to pollinator declines. However, a direct pathway connecting neonicotinoids and immune functions remains elusive. ... [This study's] results support a potential mechanistic framework to explain the effects of sub-lethal doses of neonicotinoids on the immune function of pollinators." Alexandra McPherson Caroline Boden Andrew Shalit Rachel Crossley Robert-Alexandre Poujade Camille Maclet Sebastien Soleille #biodiversity #pollinators #neonics #NA100

How do fragments of flaviviral genomes enhance viral fitness by interacting with human proteins? Discover the details in our newly published computational analysis! With Andrea Vandelli and Gian Gaetano Tartaglia Link here: https://lnkd.in/dMbev5HB #virus #RNA #secondary_structure

A good immune response is important to quickly overpower incoming pathogens. Now researchers show in Plant Cell that that basis of this response stems from 500 million years ago. Read more about this study on my blog https://lnkd.in/ez6wieju Or go directly to the article: Khong-Sam Chia, Jiorgos Kourelis, Albin Teulet, Martin Vickers, Toshiyuki Sakai, Joseph F Walker, Sebastian Schornack, Sophien Kamoun, Philip Carella, The N-terminal domains of NLR immune receptors exhibit structural and functional similarities across divergent plant lineages, The Plant Cell, 2024;, koae113, https://lnkd.in/eCJexvWy #plantscience #Evolution