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The evidence keeps building-up on the importance of #HERV-K ENV in #ALS.  GeNeuro's preclincal program is based on detecting this protein in patients and neutralizing its pathogenic effects. HERV-K (HML-2) envelope protein induces mitochondrial depolarization and neurotoxicity via endolysosome iron dyshomeostasis https://lnkd.in/eNgDTgPB

HERV-K (HML-2) envelope protein induces mitochondrial depolarization and neurotoxicity via endolysosome iron dyshomeostasis

HERV-K (HML-2) envelope protein induces mitochondrial depolarization and neurotoxicity via endolysosome iron dyshomeostasis

jneurosci.org

Robert Glanzman, MD, FAAN

Experienced Clinical Neuroscientist

7mo

If CSF reverse transcriptase positivity is a reliable biomarker for HERV-K driven pathology, all pwALS should be tested.

Lise-Marie Fueg

Expertise that cares🤝... Truly passionate CMC advisor for Pharma & Life Science start-ups 💊🧬.

7mo

Keep going #Geneuro in your research in #ALS 🙏

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