GeroScience’s Post

Today I had the opportunity to speak about deep brain stimulation and its applicability to brain disorders at the "Introduction to Neurodegenerative Diseases and Disease Models" course at Aarhus University, organised by Caroline Real Gregório and Nathalie Van Den Berge. I talked about our research on the in vivo effects of deep brain stimulation on neuroplasticity in a large experimental model of Parkinson's disease, mentored by Associate Professor Anne Landau. There were some great questions and discussions! Thanks for the invitation! #DeepBrainStimulation #DBS #Parkinsons #PETscan

Dr. (Prof. ) VS Mehta, Chairman Emeritus at Paras Health, is dedicated to dispelling common myths about brain tumors. Misconceptions around brain tumors often lead to unnecessary fear or confusion, making it essential to understand the facts. Dr. Mehta emphasizes that not all brain tumors are cancerous, and advances in treatment have greatly improved outcomes for many patients. By raising awareness and sharing accurate information, he aims to empower patients and their families, helping them approach brain health with knowledge and confidence. Let’s break the myths and spread awareness for better brain health.

What goes on behind the annual statistics? At Queen Mary University of London, Adina Teodora Michael-Titus and colleagues, alongside LASA's Chair of Scientific Programme Jordi Tremoleda, published a paper on how cellular senescence and neuroinflammation develop in juvenile mice following traumatic brain injury (TBI). The study offers insights into brain injury mechanisms. Understanding these processes can help inform treatments for TBI and related neurodegenerative disorders. Read the full paper online: https://lnkd.in/eeZTCDhm #AnnualStatistics #AnimalStats #Research #Openness

This study by Cui et al. (2024) examines the effects of UC-MSC-derived exosomes (UC-MSCs-Exo) on traumatic brain injury (TBI). Isolated through ultracentrifugation and administered to TBI models, UC-MSCs-Exo significantly improved motor function, as evaluated by the modified neurological severity score (mNSS). Additionally, immunofluorescence analysis revealed that UC-MSCs-Exo reduced excessive microglia activation by inhibiting the expression of IBA1. In vitro, UC-MSCs-Exo, particularly through miRNA-21, suppressed microglia proliferation, migration, and the release of inflammatory mediators. These findings suggest that UC-MSCs-Exo, via miRNA-21, play a key role in promoting neurological recovery and mitigating neuroinflammation in TBI. Read more: https://lnkd.in/duVr-d75 #healthcare #umbilicalcordstemcells #exosomes #stemcelltherapy #braininjury

🌟 New Guest Blog by Hugh Thomas: "Photobiomodulation: A Promising Light in Stroke Recovery" 🌟 We’re excited to announce a new guest post on our blog, written by Hugh Thomas, titled “Photobiomodulation: A Promising Light in Stroke Recovery.” In this insightful article, Hugh explores the potential of photobiomodulation (PBM) therapy as an innovative approach for supporting recovery after a stroke. Drawing on the latest research, Hugh explains how PBM works by delivering targeted light therapy to boost cellular energy, reduce inflammation, and promote neurogenesis—the growth of new brain cells. These effects are especially promising for stroke survivors, as PBM may help improve cognitive function, memory, and even motor skills, aiding recovery in ways that were previously unimaginable. Key highlights from Hugh’s post: How PBM supports brain repair post-stroke: By stimulating mitochondrial function, PBM encourages faster recovery of damaged neural tissues. Real-world applications of PBM: Hugh breaks down emerging studies that show significant improvements in patients who incorporated PBM into their rehabilitation. A brighter future for stroke recovery: With its non-invasive nature and promising results, PBM could revolutionize stroke treatment by providing a new pathway for brain healing. Whether you’re a stroke survivor, a caregiver, or someone interested in cutting-edge brain health therapies, Hugh’s post offers a fresh perspective on how PBM might be a game-changer in neurorehabilitation. 🔗 Read the full article now: https://lnkd.in/ec6UqDPj At Neuronic, we’re committed to bringing you the latest advancements in brain health. Stay tuned for more expert insights and innovations in photobiomodulation! #Photobiomodulation #StrokeRecovery #BrainHealth #NeuroRehab #PBMTherapy #LightTherapy #CognitiveHealing #Neuronic #BrainHealing #InnovativeTherapy #StrokeSupport #BrainRecovery #Neuroplasticity #WellnessTechnology #Neurotech

Dr. (Prof. ) VS Mehta, Chairman Emeritus at Paras Health, is dedicated to dispelling common myths about brain tumors. Misconceptions around brain tumors often lead to unnecessary fear or confusion, making it essential to understand the facts. Dr. Mehta emphasizes that not all brain tumors are cancerous, and advances in treatment have greatly improved outcomes for many patients. By raising awareness and sharing accurate information, he aims to empower patients and their families, helping them approach brain health with knowledge and confidence. Let’s break the myths and spread awareness for better brain health.

The science around traumatic brain injury (TBI) is deepening, in part thanks to work from University of Washington. Improved blood-based diagnostics, management algorithms, and therapeutics are essential. #TBI #diagnostics #uw

🌐 World Brain Day: Advancing Brain Health with RNA-Based Therapies 🧠 On this World Brain Day, Certest Pharma proudly joins the global community in raising awareness about brain health. At Certest Pharma, we are committed to pioneering innovative treatments that harness the power of RNA-based therapies using advanced drug delivery systems with Lipid Nanoparticles (LNPs) and ionizable lipids. The brain is a complex and vital organ, responsible for our thoughts, memories, and actions. However, it is also susceptible to various debilitating diseases. Among the most common and challenging brain diseases are: 👉🏻Alzheimer's Disease: A progressive disorder that affects memory and cognitive function. 👉🏻Parkinson's Disease: A neurodegenerative disorder that impacts movement and coordination. 👉🏻Stroke: A sudden interruption in the blood supply to the brain, leading to significant neurological damage. At Certest Pharma, we believe that RNA-based therapies represent a promising frontier in the fight against these devastating conditions. Our cutting-edge research focuses on developing targeted treatments that can effectively cross the blood-brain barrier, offering hope for improved outcomes and enhanced quality of life for patients. On this special day, we reaffirm our dedication to advancing brain health and our commitment to scientific excellence. Together, let's work towards a future where neurological diseases are better understood, better treated, and ultimately, overcome. #WorldBrainDay #BrainHealth #RNATherapy #DrugDelivery #CertestPharma

Aging Brain: Interplaying between bone marrow aging, immunosenescence, and neuroinflammation Check out our blog post https://wix.to/chJ4R9O #Aging #BrainHealth #Immunosenescence #Neuroinflammation #Research

NeuroRestore In Alzheimer’s disease, the nerve cells cease functioning as they should, which leads to a deterioration of memory and learning. AlzeCure has identified drug-like compounds that stimulate neurotrophic signaling pathways, thereby strengthening nerve cell function and improving memory. NeuroRestore is a platform of symptomatic drug candidates for diseases where cognitive ability is impaired, such as Alzheimer’s. NeuroRestore stimulates several important signal pathways in the brain, which among other things leads to improved cognition. In preclinical studies with NeuroRestore, we have been able to demonstrate that our drug compounds not only boost communication between nerve cells but also improve cognitive ability. The drug candidates in NeuroRestore stimulate signaling of neurotrophins, the most well-known of which is Nerve Growth Factor (NGF) and Brain Derived Neurotrophic Factor (BDNF). These neurotrophins are important for maintaining nerve cell function and communication, which are impaired with cognitive disorders. BDNF plays an important role for nerve cell function and communication in the areas of the brain that are essential for our cognitive ability, such as the hippocampus, located in the temporal lobe. Learn more about our platform here: https://lnkd.in/e6BR563C #alzecure #alzheimer #alzheimers #Alzheimerfonden #neurorestore