Giuseppe Biondi Zoccai’s Post

🚨 New Research Alert! 🚨 We are thrilled to share our latest publication in the Journal of Cardiovascular Magnetic Resonance! In this study, we explored how Hyperpolarized [1-13C]pyruvate Magnetic Resonance Imaging (HP MRI)can identify distinct metabolic phenotypes in patients suffering from heart failure. Our findings show that HP MRI can detect shifts in myocardial metabolism, offering potential for better heart failure phenotyping and even predicting treatment responses years in advance. 💡🫀 Key Highlights:                   •               Strong correlation between left ventricular function and metabolism                   •               HP MRI successfully differentiated metabolic activity in ischemic heart disease and dilated cardiomyopathy                   •               Baseline metabolic markers predicted heart function recovery in ischemic patients at 1 year follow up This research not only deepens our understanding of heart failure’s metabolic basis but also opens doors for personalized treatment strategies in cardiology. 👉 Read the full paper here: https://lnkd.in/e94Jc4VM #HeartFailure #Cardiology #AU #AUH #PrecisionMedicine #Research

📢 New Research Topic Launched! Submissions are now open for a new Research Topic in Frontiers in Cardiovascular Medicine exploring Cardiac Replacement Therapy. 👇 https://lnkd.in/dJPtKAdW We look forward to your groundbreaking contributions and insights! #CardiovascularMedicine #Research #CallForPapers #AcademicResearch #FrontiersInCardiovascularMedicine #ScientificPublication #OpenResearch #OpenScience #OpenAccess

We are excited to share our latest publication by the Evidinno team in collaboration with our esteemed partners at Bristol Myers Squibb highlighting how leading bodies, including the American Heart Association (AHA) and the European Society of Cardiology (ESC), define Dilated Cardiomyopathy (DCM), and how these definitions impact diagnosis and treatment. DCM is a complex condition that requires continual updates to its definition and diagnosis to improve patient care. As new insights into the underlying pathophysiology of DCM emerge, clinical and professional organizations are enhancing treatment recommendations for this serious heart condition. The current review explores the evolving role of diagnostic tools like cardiac magnetic resonance imaging and electrocardiograms, providing clinicians with a clearer understanding of this condition’s genetic and environmental factors. Read more below. https://lnkd.in/gtwazqjQ

Exciting cardiovascular research out of the University of Toronto demonstrates that macrophage-engineered human cardiac microtissues represent a considerably improved model for human heart development and reveal a major beneficial role for human primitive macrophages in enhancing early cardiac tissue function. The paper states that multidimensional #CyTOF analysis showed hESC-macrophages can reduce mitochondrial debris, increase ATP production and realign cardiomyocyte metabolism to approximate early fetal ventricular cardiomyocytes. Hamidzada, H. et al. Nature Cardiovascular Research (2024): https://lnkd.in/gtbWY8wd

https://lnkd.in/gUP2M84j Article title: C-Kit Positive Cells from Failing Human Hearts: Role of Culturing Media on Cardiomyogenic Potentials Author(s): Anna Francesconi; Gaetano Paparella*; Barbara Frossi; Elisa Del Terra; Francesco Saverio Ambesi Impiombato; Francesco Curcio Journal: Journal of Cardiovascular Medicine and Cardiology Journal ISSN: 2455-2976 Abstract: Background: The possibility of culturing heart cells in order to regenerate damaged tissue is a challenging problem. Recent observations have demonstrated the possibility of isolating and expanding resident cardiac stem cells, which could favor regeneration and functional improvement of the myocardial tissue. Aims: To investigate two different culturing media: one promoting c-kit cells' growth and the other promoting differentiation in cardiac muscle cells. #HeartFailure #CellCulture #Ckit #Differentiation #CoronaryArteryDiseases #ValvularHeartDisease #Electrophysiology #CardiacElectrophysiology #Echocardiography #InterventionalCardiology #ClinicalCardiology #NuclearCardiology #AcuteCoronarySyndromes #ArrhythmiaEP #CVImaging #CVDPrevention #CardiacArrhythmias #Peertechz #PeertechzPublications #OpenAccess #ScientificJournals #PeerReviewedJournals #OpenAccessPublishers #CardiacPhysiology #CardiacRegeneration #CardiacRehabilitation #Cardiomyopathies #CardiovascularDrugs #CardiovascularTherapy #CardiovascularAnatomy #CongenitalHeartDefects 

I’m excited to share with you my recent publication “Oxidation-reduction imaging of myoglobin reveals two-phase oxidation in the reperfused myocardium” published in Basic Research in Cardiology (BRIC, IF:9.5) 🔬🫀 📌Our study introduces a novel imaging pipeline to investigate the redox states of myoglobin in myocardial infarction (MI). It’s a significant step forward in understanding MI’s severity and could lead to better diagnostic tools. 📌This work suggests that myoglobin’s redox state can be a promising biomarker for characterizing and estimating the size of MI during the early phases of reperfusion. It’s an honor to contribute to such a meaningful study that has the potential to impact patient care positively. 👩🔬Please feel free to dive into the full article, share it, and discuss these innovative findings with me! #CardiovascularResearch #Myoglobin #Oxidationreduction #MyocardialInfarction

🚨 New Research Alert! 🚨 Check out our latest study in Circulation: Arrhythmia and Electrophysiology. FABP4, a protein linked to adipocytes, promotes fibrosis, altered glucose metabolism, and lipid accumulation in heart cells, especially in patients with persistent atrial fibrillation. It also affects calcium dynamics in cardiomyocytes, suggesting its potential role in driving atrial cardiomyopathy. Link here: https://lnkd.in/dgH2pJCk Sonia Eiras, Ana Maria Gomez, Laëtitia Pereira, Maria Gomez Lazaro, Eva Delpón #Cardiology #Arrhythmia #Research

Ongoing research highlights triglyceride-rich lipoproteins (TRL) as a key focus. ARO-ANG3 RNA interference therapy, presented at the European Society of Cardiology Congress, shows promise in significantly lowering plasma triglycerides. Stay informed about the latest breakthroughs in cardiovascular research on our website. ➡️ https://lnkd.in/ePJUwEBQ #R3i #ResidualRisk #ResidualRiskReduction #MedicalResearch #Cardiovascular #CardiovascularHealth #CVD #CardiovascularDisease #ResidualCardiovascularRisk #CardiovascularResearch #Lipoproteins #TriglycerideRichLipoproteins

Managing circadian rhythms through intense light and chronologically timed therapy can help prevent or treat a variety of circulatory system conditions, including heart disease, according to a new study. This type of research is adding to the development of a novel field of medicine termed circadian medicine. The study reviews current circadian medicine research, focusing on the use of intense light therapy following surgery, utilizing light to treat cardiac injury, exploring how cardiovascular disease can differ between men and women and administering drugs at specific times of day to coincide with the body’s internal clock to speed healing. The treatments are almost all low-risk. Some involve using light boxes, and others use drugs that are already on the market. Circadian rhythms significantly influence how the cardiovascular system operates. Timing is everything. Blood pressure and heart rates follow distinct patterns, peaking during the day and ebbing at night. When this is disrupted, it leads to worse cardiovascular disease outcomes including myocardial infarction and heart failure. Light is critical in maintaining the proper balance and functioning of the body. Shift employees who work more night hours than day hours often have worse cardiac outcomes. When light hits the human eye, it is transmitted to the suprachiasmatic nucleus, a structure in the brain’s hypothalamus that regulates most circadian rhythms in the body. Intense light stabilises the PER2 gene and increases levels of adenosine, which blocks electrical signals in the heart that cause irregular rhythms, making it cardiac protective. https://lnkd.in/gkAGdBRe

New Research Alert: Promising Results for Plozasiran in Treating Severe Hypertriglyceridemia! 🧬 A recent phase IIb trial published in JAMA Cardiology has shown that plozasiran, an APOC3-targeted small interfering RNA drug, significantly reduces triglyceride and APOC3 levels in patients with severe hypertriglyceridemia. The trial found dose-dependent reductions and a favorable safety profile, suggesting plozasiran could become a key treatment option in the future. More research is needed, but this is a big step forward! 🌟 #Cardiology #MedicalResearch #Hypertriglyceridemia #Plozasiran #HealthcareInnovations