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REPOSITORY PREPARATIONS OF PENICILLIN -G :: As mentioned in pharmacokinetics penicillin -G is rapidly excreted and the duration of action is very short Moreover because of poor absorption and destruction by gastric acid it has to be given by https://lnkd.in/dezPsasT

🌿 Exploring the Power of Crocin: The Saffron-Derived Compound with Therapeutic Potential 🌿 Crocin, a naturally occurring carotenoid extracted from the stigmas of Crocus sativus (saffron), is renowned for its vibrant color and potent antioxidant properties. Beyond its culinary applications, crocin holds significant promise in the pharmaceutical world for its neuroprotective, anticancer, and anti-inflammatory effects. In our recent analysis, we assessed the chemical composition and quality of crocin using advanced techniques such as HPLC and UV-Visible Spectrophotometry. The results show a high purity of Crocin-I (69%), confirming the presence of key bioactive compounds that contribute to its health benefits. 🔬 Key Findings: Purity: HPLC analysis reveals 97% purity, with Crocin-I dominating. Solubility: Easily dissolves in water and ethanol, enhancing bioavailability. Heavy Metals: Safe levels, all below permissible limits. Microbial Safety: Free from harmful pathogens, ensuring safety in pharmaceutical applications. Crocin’s unique chemical properties, combined with its safety profile, make it a valuable asset in drug development, particularly for neurodegenerative diseases and oxidative stress-related disorders. Exciting times ahead for natural product research and innovative healthcare solutions! #PharmaceuticalAnalysis #NaturalProducts #Crocin #SaffronExtract #HPLCAnalysis #Spectroscopy #DrugDevelopment #HealthcareInnovation #QualityControl #TherapeuticPotential #Antioxidants #MedicinalChemistry

Analysis of Δ8 and Δ9-THC Metabolites and Other Cannabinoids in Urine UCT’s #SelectraCore® PFPP column emerged as the most successful for separating the isomeric metabolites. This method separated a total of 16 #cannabinoids. Analytes were extracted from urine utilizing UCT’s #StyreScreen® HLB solid phase extraction column. After optimization, the extraction’s recovery, matrix effect, and relative standard deviation were evaluated at three concentrations (5, 25, 50 ng/mL). Recoveries for all analytes were acceptable, above 75% (range 78-118%). Matrix effects and relative standard deviations were within ANSI/ASB Standard 063 guidelines. Matrix effects were within ± 25% and the RSDs were less than 20% (range 1-15%). Learn more about Styre Screen HLB® https://lnkd.in/eJB78np9 Learn more about SelectraCore® https://lnkd.in/edGu8ed5 Learn more about SPeVAP® https://lnkd.in/evSdMa5k UCT / LabGoals 2731 Bartram Road | Bristol, PA 19007 Phone: 1(800)385-3153 Email: info@unitedchem.com Customer Support: methods@unitedchem Sales: https://lnkd.in/e_5agZUN

An advance in means to preserve stored #redbloodcells for therapeutic use: The novel gel formulation #VAS101 delivers antioxidant #curcumin to RBCs to counter #storagelesion. #Heme https://lnkd.in/e_rpsQZU

Unique Solubility Enhancement Technique by Acid-Base Supersolubilization for Weakly Acidic Model Drug Flurbiprofen showing improvement in Solubility from 9 mcg/mL to 350 mg/mL in presence of Meglumine. Thanks to Abu Serajuddin, Alex Avdeef and Hari Priya Kandagatla

New Paper on Acid-Base Supersolubilization(ABS)and Amorphization of Flurbiprofen, a Weakly Acidic Drug M. Irfan Syed, Hari P. Kandagatla, Alex Avdeef, and I recently published a paper on the acid-base supersolubilization (ABS) of flurbiprofen that could have a major impact on the development of poorly water-soluble acidic drugs in the future. While the solubility of the sodium salt of flurbiprofen is about 18 mg/mL, the aqueous solubility increases to greater than 350 mg/mL with the weak base meglumine. Amorphous solid dispersions are formed upon drying of highly concentrated aqueous solutions or melt extrusion of dry mixtures, which dissolve rapidly. You may download the paper by clicking the link below:

𝐃𝐢𝐝 𝐲𝐨𝐮 𝐤𝐧𝐨𝐰? Our Solid Phase Peptide Synthesis (SPPS) resins are used to help patients around the world manage symptoms of type 2 diabetes. More than 112 million people across Europe and the USA are affected by diabetes, with the vast majority of those having type 2 diabetes. In 2022, the European Commission and FDA both approved Eli Lilly’s Mounjaro® injection to treat adults with type 2 diabetes, using tirzepatide - manufactured by SPPS - as the active ingredient. 𝐇𝐨𝐰 𝐝𝐨𝐞𝐬 𝐭𝐢𝐫𝐳𝐞𝐩𝐚𝐭𝐢𝐝𝐞 𝐰𝐨𝐫𝐤? Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are satiety hormones produced naturally in the intestine. They promote feelings of fullness, reducing food intake. Tirzepatide is a GIP and GLP-1 receptor dual agonist, stimulating production of these hormones and leading to weight loss and improved blood glucose levels in adults. 𝐇𝐨𝐰 𝐢𝐬 𝐭𝐢𝐫𝐳𝐞𝐩𝐚𝐭𝐢𝐝𝐞 𝐦𝐚𝐝𝐞? Tirzepatide is typically manufactured using an Fmoc-Sieber amide SPPS resin. As the world’s largest manufacturer and supplier of high-quality SPPS resins, including Fmoc-Sieber, Sunresin has significant production capacity from dedicated facilities operating under GMP-like conditions. Visiting #CPhI? Chat to us at stand 2C33 to learn more about our full range of resins for SPPS to support your process. #lifesciences #peptide #synthesis #spps #innovation

Laboratories face a tough challenge in the separation of the isomeric metabolites Δ8-COOH-THC, Δ9-COOH-THC, Δ8-OH-THC and Δ9-OH-THC. Analytically these isomers can cause interferences and potentially lead to problematic misidentifications. New #cannabinoids like Δ10 and Δ6ª,10ª-THC add to the difficulty because they can be artificially synthesized. Example -> THC-O-acetate (THC-O) synthesized by adding acetic anhydride to THC. UCT presents a robust #SolidPhaseExtraction method for 16 #cannabinoids from urine and an LC-MS/MS method utilizing UCT’s #SelectraCore® PFPP and #StyreScreen® HLB. Review Poster: https://lnkd.in/e7yNhpWv Review Application Note: https://lnkd.in/em5MhtiG Talk to your Sales Rep: https://lnkd.in/eWzUE-D9 Ask UCT a Question: methods@unitedchem.com

Replacing cholesterol in #LNP with phytochemical-derived compounds, ginsenoside Rg2 and its derivative phytosterol protopanaxadiol (PPD). The expression efficiency of Rg2-LNP and PPD-LNP was found to surpassed that of the cholesterol-based LNP formulation. https://lnkd.in/eaeJu_A3

Pharmaceutics (Dosage form) : Route of the Administration of Tablet Iyad Naeem Muhammad this explains the whole process of Drug Liberation, Absorption , Distribution , Metabolism and Excretion mechanism (LADME) #pharmaceutics #dosageform #LAME #tabletdisintegration #Routeofadministration #karachiuniversity #KUstudent #medicalconcepts #studytips #studyinspiration #studyhard #pharmacy #pharmacystudent #medicalnotes #handwrittennotes