Glaucoma Today’s Post

“The detection of apoptosis and cell stress is a promising strategy for detecting neurodegenerative disease before irreversible damage occurs and for monitoring treatment response ahead of existing endpoints. This article reviews a novel retinal biomarker—the Detection of Apoptosing Retinal Cells (DARC)—and the potential for this to function as a surrogate endpoint in glaucoma and other conditions.”(…) DARC technology allows the opportunity to not only monitor disease activity (DARC count) but also treatment efficacy (reduction of DARC count)(…) With these validations, we then went a step further to assess whether DARC was predictive of changes in the brain. We found that, in a rotenone-induced animal model of Parkinson disease, DARC could detect the loss of dopaminergic cells in the eye 90 days before it could be detected in the brain.22 Additionally, in a triple-transgenic model of Alzheimer disease, DARC was predictive of a therapeutic effect of a novel curcumin nanoparticle formulation before the effect could be observed in the brain.”(..) This investigation further validated DARC as a biomarker of angiogenesis-related retinal diseases such as wet AMD and diabetic eye diseases.(…) We found that a DARC spot at baseline was predictive of a new area of exudation about 36 months later. Further, patients with a DARC count greater than five ultimately developed new lesions. Although larger validation studies are required, this finding shows the potential of DARC as a biomarker of wet AMD.(…) A significantly higher DARC count was seen in the glaucomatous eyes that were progressing versus those with stable disease. The positive predictive value of DARC was 100% for predicting glaucomatous progression. All patients who had a DARC count greater than 30 had experienced glaucomatous progression by 18 months. (…) We will soon be conducting a study to explore the use of DARC as a predictor of macular atrophy and to assess wet AMD treatment. We are also working with pharmaceutical companies to explore the use of DARC in AMD and diabetic retinopathy studies as an exploratory endpoint and as a measure of treatment efficacy.”

#NEXT_GENERATION_COMPACT_FIA_ANALYZER Our AIFA 100 is a POCT FIA analyzer based on time resolved immunofluorescence technology for quick and reliable diagnosis of several biomarkers such as cardiac, tumor, thyroid, fertility, autoimmune, bone metabolism, diabetic, infectious diseases etc. #poct #fiaanalyzer #immunofluorescence #lab #medicallaboratory #diagnostics #thyroid #fertility #diabetes #autoimmune #tumor #biomarkers #quality #results #affordable #medicaldevices #medical #healthcare #orbiton #biomedical #nepal #laboratory

Non-alcoholic fatty liver disease (NAFLD) has officially been renamed metabolic dysfunction-associated steatotic liver disease (MASLD). Metabolic dysfunction-associated steatotic liver disease reflects a broader understanding of its causes beyond alcohol. Linked to obesity and metabolic issues, MASLD encompasses varying liver conditions like MASH. Mouse models like B6-Alms1-del aid research, showing promise in understanding and treating this complex disease. Exciting progress in liver pathology treatment is underway with drugs like Tirzepatide and Efruxifermin. Learn more: https://lnkd.in/guV22v4W #NAFLD #MASLD #ObesityResearch #HealthcareInnovation #MedicalResearch #LiverDisease #HealthTech #ResearchAndDevelopment #mousemodels

Necrosis vs. Apoptosis: Understanding the Differences: Cell death is a natural part of life, but not all forms of cell death are the same. Two primary mechanisms are necrosis and apoptosis. Necrosis is an uncontrolled process of cell death usually caused by injury or infection, leading to the breakdown of the cell membrane and the release of harmful substances that can damage surrounding tissues. This often results in inflammation and tissue damage. On the other hand, apoptosis is a programmed and controlled form of cell death that is essential for maintaining healthy tissue function. Cells undergoing apoptosis break down in a way that avoids harming neighboring cells and does not cause inflammation. Apoptosis is crucial for processes such as growth, immune system regulation, and eliminating damaged cells. Watch this video to explore the key differences and understand why apoptosis is often considered a "clean" cell death, while necrosis can lead to complications. #Necrosis #Apoptosis #CellBiology #ProgrammedCellDeath #TissueHealth #Inflammation #BiologicalProcesses #CellularScience #MedicalResearch #MolecularBiology

This study provides genetic evidence to support potential associations of PCSK9-inhibitor medications with newborn malformations affecting multiple organ systems, the skin, and a cluster of structural defects simultaneously affecting the spine, anus/rectum, heart, throat, kidneys, arms and legs.There was also weaker evidence of an association of PCSK9-inhibitor medications with newborn malformations resulting in blockages of the kidneys and urine system, though the evidence was less certain for these than for the other malformations. https://lnkd.in/dR_xA6ZG

This new work from our laboratory reports that the surfactat protein A receptor SP-R210 modulates timing of birth and protection of newborn lung's alveolar-capillary integrity from inflammatory stress during fetal-to-neonatal transition

Ophthopedia Update:Ophthalmic features of Lamb-Shaffer syndrome: a case series: Lamb-Shaffer syndrome (LSS) is a rare neurodevelopmental disorder, genetically diagnosed in fewer than 100 individuals worldwide. We present a case series of 6 pediatric patients with LSS and describe its ophthalmic manifestations. Strabismus was present in 5 patients, with exotropia being most common. All subjects had significant refractive errors; 5 had astigmatism of at least 2 D. All patients had optic nerve abnormalities, including pallor (4), hypoplasia (2), and anomalous appearance (1), with retinal nerve fiber layer thinning demonstrated in a single subject. #Ophthalmology #Eye #Ophthotwitter

Hi 👋 We're thrilled to announce our newly published article on Oral manifestation of Nance Horan Syndrome 🥳🥳 Nance Horan Syndrome (NHS) is a rare congenital genetic condition. However, due to the sporadicity of cases and the similarity in manifestations of mild NHS with X-linked cataracts, it is difficult for clinicians and researchers to diagnose and treat NHS. Affected individuals frequently appear with developmental and physical problems affecting various bodily systems. The resulting dental anomalies may have a direct impact on oral function, resulting in problems with speech articulation, chewing, and even tooth alignment, which may cause malocclusion. To continue, kindly click on the link to https://lnkd.in/efHmyh2D

IN PRESS: review in the journal Transplantation, co-authored by our Shadab Siddiqui, M.D., on the impact of pretransplant diabetes mellitus in liver transplant: analysis of secondary outcomes reveals pre-LT DM is a significant predictor of post-LT cardiovascular events and end-stage renal disease. Meta-regression of other patient characteristics identified Asian ethnicity and hypertension to be significant predictors of worse overall survival, whereas African-American ethnicity was associated with significantly improved overall survival in patients with pre-LT DM. #liver #Livertwitter https://bit.ly/3Qmkbbo

Focused on the Few #WorldHealthDay