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Mounjaro ( Tirzepatide ) a new introduction in health diabetes. Drug class - Glucose dependent insulinotropic polypeptide GIP and Glucagon like peptide 1 agonist. patients counselling points for pharmacist... educate pt about Dosing. pt need to take initial 2.5mg/week by subcutaneous route. increase dose after 4 weeks upto 5mg/week SC route. if pt need high Dose, Dose should be increased after every 4 weeks upto 15mg/week SC route. Tirzepatide decrease absorption of some oral medication. Tirzepatide may increase heart rate , provide education to pt to take caution if pt taking other medications having this effect.. #mounjaro #diabetic

- The FDA has granted approval for Merck's treatment, Winrevair, for adults with high blood pressure due to lung artery constriction, causing pulmonary arterial hypertension (PAH). - Winrevair is expected to be priced at $14,000 per vial, with an annual cost of $238,000 per patient, and Merck plans to bring it to market by the end of April. - Analysts predict strong initial sales for Winrevair, estimating peak sales of approximately $5 billion by 2030, based on its potential to become a standard treatment option for PAH patients. To know more, read the full article on #theenterprise #Merck #Winrevair #FDAApproval #PulmonaryArterialHypertension #PAH #Healthcare #MedicalNews #DrugApproval #globalbusiness #theenterprisenews #followformore #global #finance

Among the many medications used to combat #insulinresistance and #type2diabetes, thiazolidinediones (TZDs; e.g., "~glitazones") are interesting. That they work is clear--they improve insulin resistance--however, the mechanism of action is often unappreciated. TZDs act primarily by increasing the ability of fat cells in the subcutaneous depot (i.e., fat beneath the skin; the fat we pinch and jiggle) to multiply. Critically, smaller fat cells are more insulin sensitive than larger fat cells. Thus, the drugs improve the metabolic profile by taking a limited number of hypertrophic (i.e., large), insulin-resistant fat cells and replacing them with more, but smaller, fat cells. Paradoxically, this means a person will gain weight, yet become more insulin sensitive. This is strong evidence that fat mass matters much less than fat cell size. This study (linked below) indicates that TZDs result in a shift in how we store fat, leading to reduced visceral fat and increased subcutaneous fat. This represents another aspect of human fat storage--visceral fat storage (which overwhelmingly involves fat cell hypertrophy) is a result of running out of subcutaneous fat storage capacity. If you increase the capacity of the subcutaneous fat (e.g., through TZDs), there's less "pressure" to store it in the visceral space. https://lnkd.in/g3ZnRNkX

For patients with cardiovascular issues requesting #Azithromycin, it's crucial to inquire about concurrent use of #Amiodarone. This drug combination heightens the risk of developing a potentially fatal abnormal heart rhythm ❌️. If the use of this combination is necessary, close monitoring of the QTc interval and heart rhythm is crucial. Consider alternatives whenever possible to mitigate these potentially severe risks. Check out the carousel below for more information on this serious interaction. #medication #pharmacy #pharmacistlife #druginteractions #Azithromycin #Pharmacist Reference: https://lnkd.in/dM75qNtq

 A Guide to Safeguarding Yourself from Drug Interactions

Watch our Co-founder and Director of Operations share insights on hypertension in a special video for World Hypertension Day. #worldhypertensionday #hypertension #awareness #spreadawareness #bloodpressure #safevig #newinnovations #innovations #bpmanagement #bloodpressuremanagement #hypertensionmanagement #healthylifestyle #controlbp #controlbloodpressure #pharmacovigilance #idorsia #newdrugs #FDAapproval #FDA

Daily Critical Care Pearls #128: Understanding and Preventing Iatrogenic Hyperchloremia 📌Iatrogenic hyperchloremia occurs when excessive exogenous chloride is given during the treatment of another condition. This is almost always due to the administration of IV fluids containing sodium chloride 📌Decreased renal perfusion, acute kidney injury, and metabolic acidosis are known consequences of hyperchloremia 📌The normal physiologic levels of chloride are 98 to 108 mEq/L, but the most common crystalloid IV fluid, normal saline, contains 154 mEq/L 📌Prevention of iatrogenic hyperchloremia can be accomplished by using alternative IV fluids or reducing the amount of fluids given overall. 📌Alternative crystalloid fluids include lactacted ringer's solution and Plasma-Lyte which contain 109 and 98 mEq/L of chloride, respectively which is right at the normal physiologic range. These solutions are referred to as balanced crystalloids 📌Management of DKA: While ADA guidelines still recommend normal saline, they have not been updated since 2009. However subgroup analysis of major trials (PMIDs: 29485925, 29485926) suggests that DKA may actually resolve faster if balanced crystalloids are used in place of normal saline #criticalcare #pharmacy #medicine #clinicalpharmacy #pearls

It's essential to be aware of potential drug interactions, especially for patients with #cardiovascular issues. Combining #Azithromycin with #Amiodarone can indeed increase the risk of dangerous heart rhythm abnormalities. Close monitoring and consideration of alternative treatments are vital to ensure patient safety. Always consult #healthcareprofessionals for personalized advice and guidance.

World Hypertension Day, observed on May 17, focuses on raising awareness about the critical importance of monitoring and managing blood pressure to prevent complications related to hypertension. It urges people worldwide to embrace healthier lifestyles and have regular medical check-ups to keep high blood pressure under control. I have done my part; now it's your turn to spread the awareness. #worldhypertensionday #hypertension #awareness #spreadawareness #bloodpressure #safevig #newinnovations #innovations #bpmanagement #bloodpressuremanagement #hypertensionmanagement #healthylifestyle #controlbp #controlbloodpressure #pharmacovigilance #idorsia #newdrugs #FDAapproval #FDA

Thank you for bringing this important issue to light. The overprescription and misuse of PPIs (Proton Pump Inhibitors) have indeed become a concerning trend. PPIs are often prescribed habitually considering them harmless especially whenever pain killers are prescribed, even when initially indicated are continued indefinitely without adequate justification. Furthermore, patient self-medication and advice from non-medical sources, including chemists, exacerbate this problem. short-term prescriptions can lead to long-term use, potentially causing significant health risks. Addressing this requires a multi-faceted approach, including better education for both healthcare providers and patients about the appropriate use of PPIs, stricter regulations on their sale, and more comprehensive monitoring of prescription.