Glow Studio’s Post

Molecular Devices is honored to be designated as a "Lab of the Future Company." Exhibitors that received the #SLAS2024 Lab of the Future designation have demonstrated their ability to provide solutions that go beyond automated instrumentation alone to push the boundaries of current technology and break new ground in achieving complete integration of automated workflows in the lab space.   Take a step ‘back to the future’ and revisit us at SLAS2024 – explore six posters that feature this groundbreaking innovation and unveil the latest advancements in laboratory research and technology:   1️⃣ CellXpress.ai Automated Cell Culture System: Automated workstation for reproducible organoid cultivation 2️⃣ Scalable patient-derived 3D colorectal cancer organoids in high throughput applications 3️⃣ A walkaway solution for assessing drug effects on patient-derived cancer organoids 4️⃣ Automation of the full workflow for 3D cancer spheroid assays with CellXpress.ai Automated Cell Culture System 5️⃣ Functional characterization of healthy and Alzheimer’s disease-related 3D neurospheres formed using Human iPSC-derived glutamatergic neurons, GABAergic neurons, and astrocytes 6️⃣ Transform the complexities of 3D cell culture into a reliable and translatable science: Automation of 3D organoid culture and organoid analysis.   Visit Lab of the Future ➡️ https://bit.ly/3XakcDG #LabAutomation #3DBiology #Organoids #CancerResearch #CellCulture

White paper: Analysis of Organoid and Immune Cell Co-Cultures By Machine Learning-Empowered Image Cytometry 3D #organoids offer an incredibly useful tool to enhance our understanding of the intra- and inter-cellular mechanisms within tissues for medical research. The recently launched #StrataQuest Organoid App effectively tackles these challenges associated with organoid research by autonomously identifying organoids, enabling to monitor their growth under various conditions, and quantifying their count, dimensions, and density within co-cultures involving #immune cells. This advancement facilitates in-depth investigations into intricate matters concerning the immune system, translational #medicine, #oncology, precision medicine, and beyond. Read the paper here: https://lnkd.in/gybjKgED

'Niels Eijkelkamp, principle investigator at the Center for Translational Immunology of #umcutrecht, has always been fascinated by the interaction between the #nervous and the #immunesystem. He studies the mechanism underlying #pain and we had the pleasure to interview him about his research for our latest #ICI bulletin! Check out the interview! Read the full bulletin here: https://lnkd.in/ekZMJcVj

Important knowledge..!!

This research finding published in the Journal of Molecular Pathology in 2024 highlights the significant gaps in biomarker delivery across Heathcare Systems. "By addressing gaps in turnaround time, biomarker accuracy and reporting clarity, optimal targeted treatments will become more accessible to all patients." #precisionmedicine #precisiononcology #biomarkertesting

Do you work in biomedical research and apply medical imaging techniques in your work? Don't miss the free Bruker webinar on April 25, at 4 PM CET! Check it out: https://lnkd.in/gMC-SfDP Dr Samuel Valable, Research Director at ISTCT Lab at Cyceron Research Center, and Dr. Mickaël Bourgeois, Radiopharmacist & Associate Professor at the Nantes University Hospital, will show examples of how #hypoxia mapping can be used to adapt loco-regional treatment such as external radiation therapy. They will also discuss the currently available methods used to detect hypoxia using both #MRI and PET imaging and, in particular, the [64Cu]-CuATSM metabolism and the use of this radiopharmaceutical in different preclinical and clinical pathologic models, providing provide examples of hypoxia #imaging in brain tumor situations (high-grade gliomas, brain metastases) in rodents and in the clinic. #PreclinicalImaging #Oncology #BrainTumor #Bruker

ASI's HyperSpectral Imaging and Analysis system marks a significant advancement in pathology research. This technology enables detailed analysis of both brightfield and fluorescence samples, essential for clinical laboratories. It excels in extracting crucial quantitative, spectral, and morphological information, offering insights into cellular and molecular structures.   The system's capabilities include identifying chemically similar areas not visible to the naked eye, separating spectral components, and providing accurate, quantitative data at the cellular level. This makes it invaluable in diverse research areas like cell biology, immunology, and pharmaceutical development.   #PathologyResearch #HyperSpectralImaging #ClinicalLaboratories #CellBiology #Immunology #PharmaceuticalDevelopment #ASI

#researchadvance Researchers from Leiden University Medical Center investigated the mechanism of cDC1 licensing in human cells and the tumor microenvironment (TME) setting, and their data were recently published in Cellular and Molecular Immunology: https://lnkd.in/eG97HvYQ Their research suggests that IFN-I signaling induced by activated CD4+ T cells licenses cDC1 to induce antitumor CD8+ T cell responses, which might be associated with improved clinical outcomes. This helper role of CD4+ T cells in the TME may help overcome suboptimal priming of CD8+ T cells. Further research could shine more light on the role of various immunotherapies in improving this helper role and overcoming inhibition of this mechanism in the TME. #biologyfront #sciencenews #biologyfront #newpaper #researches #Tcell #molecularbiology #cancerresearch Image from ACIR

Interested in learning more about how InSituPlex® multiplex immunofluorescence (mIF) assays and advanced spatial image analysis are used to evaluate efficacy in immunotherapy clinical trials? Join our Xtalks webinar on June 24th at 10:00 am ET, titled “Investigating Cell Therapy Efficacy Mechanisms in Solid Tumors by Spatial Immunophenotyping.” Adaptimmune’s Dr. Martin Isabelle and Dr. Robyn Broad will highlight: *How Ultivue’s mIF 8-plex panels enable the multiplex profiling of targets within a single tissue section while preserving the architectural features of the tumor microenvironment (TME). *How advanced spatial image analysis is being used to capture cellular spatial patterns within the tumor, both before and after treatment, to understand the effectiveness and mechanism of cell-based therapies. *How Ultivue’s InSituPlex® mIF assays are utilized alongside conventional histology, multiplex IHC, and other spatial proteomic and transcriptomic platforms to develop effective immunotherapies. Register today! https://hubs.ly/Q02BQQBQ0 #mIF #multiplex #immunotherapy #biomarkers #TumorMicroenvironment #webinar #SpatialAnalysis #SpatialBiology #CancerResearch #CellTherapy #InSituPlex

CAR-T cell expansion and persistence in vivo are correlated with treatment success, so sensitive & reliable monitoring tools are valuable: https://lnkd.in/g3xD5TKr This recent paper describes and validates a ddPCR-based approach to monitoring the expansion and persistence of CAR-T cells in patients with B-cell malignancies. The researchers demonstrated how ddPCR assays could be used to sensitively and precisely quantify CAR-T copy number across a variety of sample types, including blood and bone marrow, supporting future clinical research applications. Learn more about Droplet Digital PCR tools for cell therapy here: https://lnkd.in/gqckGuNZ #CellTherapy #ddPCR #Hematology