Gregory Miller’s Post

Excellent interview from Mathai Mammen, M.D., Ph.D. ..."80% of proteins are undruggable…. Why are most things undruggable"? "...there was a time in the late 90s, drugs were found thru phenotypic screening… most targets were Zion channels…as we saw inflection after inflection of data, sequencing data, we find more and more targets coming forward that are intracellular protein interactions, far more complicated to inhibit with small molecules… to do so it needs a covalent handle OR it needs a cavity, hydropic or creatable from a non-existent pocket (cryptic)…it is possible to find something cryptic. What FogPharma has done is to create a kind of motif that we interfere with protein-to-protein interactions. Does nature put large structures inside cells? Yes, viruses do it all day long… they use alpha helices… this is very important… next level of problem is can we use that, but most protein structures want to be something else… fog learned how to stabilize a structure in a alpha helices. These are not easy to construct. Fog has now 100s of ways to stich an alpha helix. This is an entire revolution and now it doesn’t matter what the composition is and allows astronomical diversity in terms of amino acid placement..” #biotech #fog #proteinengineering #innovation #lifesciences

Check out CEO Murat Cirit's conversation with Brad Loncar from BiotechTV about humanizing drug discovery with the #LiverTissueChip and Javelin platform. Javelin human tissue chips bring both human complexity and specificity for acute and chronic studies. The chips generate longitudinal, high-content, and human-relevant data. Javelin AI-enabled digital twin technology analyzes multi-modal chip data and translates to human responses to design better medicines faster. #AlignSummit24

𝐁𝐫𝐢𝐠𝐡𝐭 𝐌𝐢𝐧𝐝𝐬: TCGX's Chen Yu describes the benefits of being able to focus on public and privates during different stages of the biotech cycle. Dr. Yu describes how TCGX's structure and nimbleness has led to investments in a number companies that have been acquired over the last year. Full video: https://lnkd.in/ghWbWv7p BiotechTV is brought to you by: Mispro | Breakthrough Properties | HSBC Innovation Banking | Theragent Inc | NYSE | Allucent

Unlock the future of automated biobanking with the Hatch Series! Join us for an insightful look into how our innovative system streamlines the process, ensuring the highest standards of sample preservation and management. Watch the video and discover how the Hatch Series is setting new benchmarks in biobanking. #HatchSeries #BiobankingInnovation #AutomatedBiobanking

Recently, Pascal Besman, our COO, had an interesting chat with BiotechTV about how #PharmaMar is dedicated to discovering new medicines from marine compounds. 🔹 Pascal shared a powerful thought: “We are a global, revenue-producing, profitable company.” This reflects our commitment to making a positive impact in the health sector. 🔹 He also emphasized the importance of presenting ourselves as a global company: “You don’t want to project yourself as foreign; you want to project yourself as a global biotech company.” At #PharmaMar, we believe that diversity and adaptability are key to attracting investors and collaborating in the biotech field. If you’re part of the industry or just interested in biotechnology, watch the full interview for valuable insights! 📽️ https://lnkd.in/gtqQ7yQU

happy to share this important perspective on #biobanking from two organizations that I support: IUCN and the San Diego Zoo Wildlife Alliance . Biobanking addresses a critical issue of our times: the opportunity to safeguard genetic capital, support population sustainability, and reduce wildlife extinction risk. #sandiegowildlifealliance #iucn #wildlife #wildlifeconservation #nature #conservation #genetics

We're thrilled to share that SRP has featured our latest developments! Premialab has recently expanded its Pure Factors suite with the introduction of three new factors specifically designed for downside protection in volatile markets and tail risk mitigation : 🔷 Premialab Equity US Dispersion Pure Factor® 🔷 Premialab Equity US Long Volatility Pure Factor® 🔷 Premialab Multi Asset Global Tail Hedge Pure Factor® These innovations confirms our ongoing commitment to providing cutting-edge data and analytics in #QIS. Curious to learn more? Dive into the full article here: https://lnkd.in/eYzj8ehm #PureFactors #Benchmarks #Dispersion #Volatility #TailHedge

The problem / limiting factors in the Immuno-Oncology space these days: "....the problem is a lack of good targets. The field is developing assets twice as fast as we’re discovering new targets to go after. And as a result, we have 5x as many assets per target versus a decade ago. This is not just oncology this is incredibly pronounced in other areas. This doesn’t end well. Companies are competing in crowded markets and patients get left behind that we don’t know how to target well. Uncontrolled assets without known targets will be the challenge in the next couple of years.” How to solve for this problem? Enter Cartography Biosciences: "Finding new and novel targets. If you want to understand what targets that predict the particular cell types in the tumor you have to understand the tumor itself, which cells are malignant, what is on every one of those cells, and each target you are analyzing where those are expressed on every other cell and thus you have to map out every cell type in the human body. Tens of millions of cells, terabytes of data, then you can ground out, bottom's up approach -- how do we build computational frameworks that is most specific to the cells we are trying to target. This is a data driven approach for target driven biology.” WOW! 💓 #biotech #immunooncology #biology #drugdiscovery #computationalbiology #innovation #drugdevelopment

🌟 As the journey at #DIA2024 comes to a close, there's still time to connect with the Ennov team! Tim Kroboth Sonia Tomar Paul LaGrone Arnaud Lasson 🤝 You can find us at Booth #1427. Don't miss this opportunity to meet, share insights, and explore innovative solutions together. 🚀 Looking forward to seeing you there! ✨ #DIA2024 #ENNOV #Innovation #Compliance #Regulatory #QualityManagement

mastertrust was featured in The Tribune Read the views by Ms. Palka Arora Chopra, Director - Master Capital Services, sharing insights on "Upbeat trends in US, Asian markets power Sensex to reach record high" #mastertrustinmedia #mediaarticle #mediacoverage #featured #coverage #indianstockmarket #financialfreedom #mastertrust #sensex #39yearsofmastertrust