HAYA Therapeutics’ Post

How quickly can lncRNAs influence gene expression? A recent study reveals that the lncRNA Firre can impact epigenetic and transcriptional states within just 30 minutes of induction. The research, tracked Firre-induced regulatory events from 15 minutes to four days. Surprisingly, Firre RNA triggers early regulatory events within 30 minutes, leading to significant transcriptional changes after 12 hours—earlier than seen in previous lncRNA studies. Moreover, these changes are epigenetically remembered for several days, suggesting a lasting influence on gene expression. While these findings are groundbreaking, further research is crucial to unravel the mechanisms driving these swift and enduring alterations. The implications of this study could be profound in shaping new therapeutic approaches targeting lncRNAs. For more details, check out the full paper: https://lnkd.in/gh4i8qPd This message was brought to you by Nature Publishing Group AI paper summary :) #lncRNA #epigenetics #transcription

Rejuvenate Bio shows epigenetic reprogramming extends lifespan in normal mice New paper first to show that gene therapy-mediated partial reprogramming extends lifespan and reverses age-related changes in aged wild mice. #longevity #lifespan #reprogramming

Really interesting work by scientists at Rejuvenate Bio demonstrating extended #lifespan AND #healthspan in aged male mice administered AAV-directed inducible expression of Yamanaka transcription factors to partially reprogram DNA methylation patterns associated with advanced #aging. The AAV9 system used significantly reversed #epigenetic age in #liver and #heart, but not in #brain. Notably, targeting peripheral tissues could still have measurable #antiaging impact. The comparatively transient/ inducible nature of gene manipulation implemented might have decreased likelihood of cMyc driven teratoma formation, which is a critical concern when enhancing expression of anti-aging (but #oncogenic) factors. Avoiding teratoma formation may also be a question of which tissues are targeted for partial epigenetic clock rejuvenation. It really would be cool to see how this works in aged female mice! Original research article here: https://lnkd.in/gtnRE7Xf #longevity #geneediting #futuremedicine

Gene therapy restores vision in first-ever trial for rare, inherited #blindness #raredesease #genetherapy #gene https://lnkd.in/d-BQf5pm

APOE ε4 genetics isn't destiny when it comes to Alzheimer's disease. This recent study highlights a significant finding: certain versions of the fibronectin 1 gene (FN1) may protect people with two copies of the APOE ε4 gene from the increased risk of developing Alzheimer's disease. Consider this in addition to research on the value of proactive lifestyle choices in reducing Alzheimer's risk.

Visualizing Protein Complexes on specific enhancers in Drosophila Larval nuclei - https://scft.link/2CMFI Dr. Samir Merabet and Dr. Solène Vanderperre from the University of Lyon have developed a technique called BiFOR, combining BiFC and ANCHOR DNA-labeling, to visualize protein complexes in Drosophila larval nuclei. Their research, published in Cells, uncovers the dynamics of transcription factor interactions on specific enhancers, providing insights into gene regulation. #Drosophila #GeneRegulation #ProteinComplexes #BiFOR #MolecularBiology #sciencefeatured #sciencenews

Exciting news in vision research! A recent phase 1/2 trial has shown promising results with CRISPR gene editing, significantly improving vision in 11 out of 14 participants with inherited blindness. Learn more: https://brnw.ch/21wLRHM #RetinaCare #EyeHealth #Ophthalmology #VisionCare #EyeCare #RetinaSpecialists

Exciting news in vision research! A recent phase 1/2 trial has shown promising results with CRISPR gene editing, significantly improving vision in 11 out of 14 participants with inherited blindness. Learn more: https://brnw.ch/21wLePG #RetinaCare #EyeHealth #Ophthalmology #VisionCare #EyeCare #RetinaSpecialists

Exciting news in vision research! A recent phase 1/2 trial has shown promising results with CRISPR gene editing, significantly improving vision in 11 out of 14 participants with inherited blindness. Learn more: https://lnkd.in/gTpNQCwP #RetinaCare #EyeHealth #Ophthalmology #VisionCare #EyeCare #RetinaSpecialists

Exciting news in vision research! A recent phase 1/2 trial has shown promising results with CRISPR gene editing, significantly improving vision in 11 out of 14 participants with inherited blindness. Learn more: https://brnw.ch/21wLeQ3 #RetinaCare #EyeHealth #Ophthalmology #VisionCare #EyeCare #RetinaSpecialists