Health Sciences Authority’s Post

Finished the course the “Foundational Statistics for Forensic Toxicology - Session 2: Distributions & Standard Deviation Forensic Technology Center of Excellence – Awarded by the National Institute of Justice, Office of Justice Programs, U.S. Department of Justice. "two of six-part series" This session explores various distributions commonly encountered in forensic toxicology (normal, rectangular, etc.). Participants learn about the characteristics of these distributions and how they manifest in toxicological data. Also, this session covers statistical measures that can describe and compare distributions, including variance, standard deviation, and relative standard deviation. Through practical examples, participants gain insight into how these statistical techniques are applied in forensic toxicology. Upon completion, attendees will: Be provided definitions and examples of distributions encountered in forensic toxicology. Increase their understanding of the distinctions between various distributions and the implications therein. Be provided terms and definitions of descriptive statistics for distributions and appropriate usage in forensic toxicology.

Finished the course the “Emerging Forensic Research Series: Forensic Toxicology & Drugs” from Forensic Technology Center of Excellence – Awarded by the National Institute of Justice, Office of Justice Programs, U.S. Department of Justice. Detailed Learning Objectives: An overview of three NIJ-supported emerging research projects in toxicology and controlled substances and their progress. Potential impact of these research projects to the forensic community. Discussion of next steps and transition of this research into the forensic community. While this research presented may be ongoing, this series presents a unique opportunity for researchers to connect and discuss the impact of their research, early research outcomes, challenges, and technology transition pathways. -Research and Presentation topics will include the following: -Development and validation of a novel blood protein modification assay for retrospective detection of drug exposure. -Retrospective identification of synthetic cannabinoids using archived high resolution mass spectrometry data. -Development of matrix matched quality control materials and sample preparation techniques for the analysis of marijuana infused products -Coupling Raman spectroscopy with ambient sampling, portable mass spectrometry for on-site, high-throughput evidence confirmation

Phenibut: A drug with one too many “buts” New review in Basic & Clinical Pharmacology & Toxicology aimed to summarize the current knowledge on phenibut - a drug that was developed in the former Soviet Union to overcome anxiety and improve cognitive function in military personnel - and its toxicology, pharmacology, adverse health effects, and patterns of use. It found that while the therapeutic effects of phenibut remain questionable, many negative health effects, such as intoxication, withdrawal, and addiction, have been reported. Some of these effects can be life-threatening, requiring hospitalization. As control over phenibut online marketing seems unrealistic, current efforts need to be focused on the addition of phenibut to current drug screening tests and the development of generally accepted treatment strategies for phenibut-associated toxicities. Review conducted by Bill Gurley and Igor Koturbash. Read the full paper here: https://lnkd.in/dC8KiXV6

⭐ COURSE OF THE WEEK ⭐ Today, we are highlighting course 7 of our Core Concepts Series all about Inhalants. This is often an overlooked drug class, but toxicologists should be knowledgable about any drug class they may encounter. This course on inhalants covers the pharmacology, forensic toxicology, and clinical toxicology of inhalants. - In the pharmacology lesson, members will learn about how inhalants act on the body including their rapid absorption into the bloodstream and their inhibitory effects. - The forensic toxicology lesson will cover the considerations that need to be taken when analyzing body fluids for inhalants and some behavioral effects that are relevant to practicing toxicologists. - Then in the clinical toxicology lesson, our instructor explains which groups primarily abuse inhalants and the clinical effects that are seen post-inhalation. Huge thanks to Michelle Peace, PhD, Joey Jones, MS, and Dayne Laskey, PharmD for being part of this series! Join DrugImpairment.com today to expand your knowledge on this drug class! --> https://buff.ly/48JdsjG

🌟We’re pleased to share that our colleague Arianna Bassan contributed to a landmark publication on safety aspects in drug discovery and development.🌟 Arianna’s expertise is featured in the "In Silico Toxicology" chapter, which explores computational toxicology and QSAR — key areas of knowledge at our company. This chapter provides an in-depth review of in silico methodologies, focusing on structure-activity relationship (SAR) models for predicting toxicological endpoints. Readers can expect valuable insights into prediction methodologies, relevant databases, and critical considerations for identifying and selecting in silico models for toxicicity prediction. 📖 We’re proud to support advancements in safe and efficient drug development practices! https://lnkd.in/e2Pw23rW #QSAR #Insilico #DrugDiscovery #DrugDevelopment #Safety #Computational #Toxicology

Forensic toxicology is part of the science of pharmacology and is defined as the analysis of biological samples for the presence of drugs and metabolites or biomarkers. This also includes studying the adverse effects of drugs and chemicals on living organisms. Explore our systems, solutions, and content related to forensic toxicology here: https://bit.ly/4bhgwn2 #ForensicScience #Toxicology #Pharmacology #LabScience

I’m happy to share that I’ve obtained a new Certificate of Attendance: Forensic Lab Talks #7: Analytical Characterization of Emerging Drugs – Practical Approaches to Address Forensic Science Challenges from American Academy of Forensic Sciences! The drug environment in the United States has evolved significantly over the last decade in large part due to changes in the production of drugs consumed recreationally and the interest in new or alternative pharmacological highs. Today, nearly all of the drugs that emerge into the recreational drug supply are produced synthetically, and final drug products often contain more than one substance to elicit the best use experience. These changes in drug markets and supplies have had direct impacts on forensic science, especially the practices of forensic chemistry and forensic toxicology which are devoted to the detection and characterization of drugs in a variety of sample forms. Fortunately, as drug markets have evolved, so too have technology and instrumentation. Novel assays are constantly developed to detect and quantify emerging drugs in toxicology specimens and drug materials to aid forensic investigations. The most commonly employed emerging analytical techniques used are high performance liquid chromatography, tandem quadrupole mass spectrometry, and high-resolution mass spectrometry. This virtual seminar presented by Dr. Alex J Krotulski, PhD, MSFS Director of Toxicology & Chemistry, The Center for Forensic Science Research & Education (CFSRE), Horsham, PA focused on newly developed workflows and techniques for the analytical characterization of emerging drugs, including focus on qualitative methods and quantitative methods. Attendees experienced a glimpse into a state-of-the-art forensic laboratory in its pursuit against the emergence of new drugs, adulterants, drug combinations, and novel psychoactive substances. Key Learnings: •Understanding the analytical techniques used for the qualitative detection, identification, and characterization of emerging drugs in forensic sample types.  •Understanding the process and options for quantifying drugs in toxicology specimens and drug materials. •Understanding how to evaluate the data collected to determine if the analytical features match the expected molecular components.

Hello connections !! ☺️ Let us discuss on the topic, "The Growing Importance of Preclinical Toxicology in Drug Development" In the journey from molecule to medicine, preclinical toxicology plays a pivotal role in ensuring safety and efficacy. As a Junior Research Officer with M.Pharm in Pharmacology and Toxicology, working at JRF Global I’ve witnessed firsthand how crucial these studies are for identifying potential risks and shaping safer therapies. In my work, I specialize in repeated dose toxicology, and advanced techniques like jugular vein cannulation and Intra-cerebroventricular (ICV) cannulation. Managing studies under GLP standards and utilizing tools like Pristima for efficient data handling has given me a deep appreciation for how technology and precision are transforming the toxicology landscape. Preclinical toxicology doesn’t just meet regulatory requirements—it builds the foundation of trust for every new drug. With rising innovations in administration routes and study designs, we’re better equipped than ever to predict outcomes and protect patient safety. I’m excited to contribute to this evolving field and continue learning from the incredible community of toxicology and drug development professionals. What are your thoughts on the role of preclinical toxicology in today’s fast-paced drug development ecosystem? Let’s discuss!

🌟 Excited to Share! 🌟 I am thrilled to have actively participated in the One-day National Seminar on "Insights and Innovations in Safety Pharmacology & Experimental Toxicology", organized by the Department of Pharmacology at R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur. This enriching experience provided me with valuable knowledge and insights into safety pharmacology and experimental toxicology, broadening my understanding of this critical field. Thank you to the organizers and the esteemed speakers for making this seminar an exceptional learning platform. I look forward to applying these learnings in future endeavors! #ProfessionalDevelopment #Pharmacology #Toxicology #LearningJourney

📢 Wonderful! 📢 Thanks to the organizers + enthousiastic presenters of today's webinar and thanks to the audience! Check for the follow-up 2-days hands-on free of charge live workshop in Utrecht, (close to the CS), location Health-RI on 28+29 of May 2024 on "FAIR-ification of Toxicological Research Output: Leveraging ELIXIR Resources" . This workshop is a face-to-face, free-of -charge hands-on workshop, organised in the context of the first implementation study (INTOXICOM) of the ELIXIR Toxicology Community. https://lnkd.in/eCnHVZHt There are limited places! so be fast. SCIENTIFIC ORGANIZERS  @Marvin Martens (NL), Penny Nymark (SE), Iseult Lynch (UK) TARGET AUDIENCE Toxicologists interested in using FAIR data resources or making their data FAIR, Toxicologists working on or using the concept of AOPs (experimental, towards (regulatory) application)