#PrePrintAlert! 🚨 Imagine visualizing the impact of a disease on every single cell in the body! #HelmholtzMunich expert Prof. Ali Ertürk & colleagues have developed #MouseMapper, a groundbreaking #AI tool designed to reveal system-wide disease pertubations. In the latest study, MouseMapper uncovered obesity-induced changes in facial nerves and organ-specific inflammation. We’re excited to share this innovative approach! 🚀 Check out the 📰 Preprint: https://lnkd.in/dEZkSNnT and the 💡Tweetorial by Prof. Ali Ertürk: https://lnkd.in/duwmfnbh #MouseMapper #obesity #vDISCO #clearing #imaging #BiomedicalResearch #DeepLearning
CEO of Deep Piction. AI-based technologies for health. Director at Helmholtz Munich, full Professor at LMU Munich. Twitter @erturklab.
Imagine seeing a disease's impact on every cell in the body. Now, you can! We introduce MouseMapper, an innovative AI tool we've developed to reveal system-wide disease perturbations. In our recent study, MouseMapper unveiled obesity-induced changes in facial nerves & organ-specific inflammation. 🔗 Read our preprint: https://lnkd.in/dEZkSNnT or tweetorial: https://lnkd.in/dHDz3NY3 Key highlights: 1️⃣ MouseMapper combines three AI modules to segment peripheral nerves, detect immune cells, and map these structures to organs and tissues, providing a comprehensive view of the body's response to obesity. 2️⃣ We generated the first-ever whole-body nerve segmentation maps for lean and obese mice, revealing significant changes in the facial trigeminal nerve of obese mice. 3️⃣ Spatial proteomics on the trigeminal ganglion uncovered multiple differentially regulated pathways in obese mice, potentially explaining the observed nerve alterations. 4️⃣ We quantified immune cell clusters in obese mice, confirming elevated inflammation across tissues and providing detailed spatial insights into obesity-driven systemic inflammation. Why this matters: Understanding obesity's systemic effects can lead to better treatments. MouseMapper enables researchers to identify new therapeutic targets by revealing how different tissues and organs are impacted. 🌐 We're making the data and algorithms behind MouseMapper freely available. Explore the obesity-induced changes in different tissues/organs via our online atlas. While this study focuses on obesity, MouseMapper's versatility makes it a powerful tool for studying other complex conditions, such as neurodegenerative diseases, cancer, and cardiovascular diseases. I'm incredibly proud of our team's work, especially our first authors: Doris Kaltenecker, Izabela Horvath, Rami Al-Maskari, Zeynep Ilgin Kolabas, and Ying Chen. What diseases should we map next? The possibilities are endless, and we're just getting started! #BiomedicalResearch #AI #DeepLearning #ObesityResearch #MouseMapper
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2moInsightful !