Holoclara Inc’s Post

At #AspenIdeasHealth, our co-founder and CEO Andrea Choe took the main stage to present her “Big Idea” of harnessing worms for better human health. Later, she chatted with CBS News Chief Medical Correspondent Jon LaPook about the ongoing impact worms have had on our health. Some of our favorite highlights and the recording below 👇Thanks to Aspen Ideas for inviting Andrea and worms to a weekend of extraordinary ideas! https://lnkd.in/gy-zurDn 🪱 Regions without worms in their environments have the highest incidence of some of the most chronic debilitating diseases in the world: allergic and autoimmune disease.  🪱 This isn’t a coincidence: Studies have shown that worms or worm-derived molecules blocked inflammatory bowel disease, asthma, multiple sclerosis, and many other disorders. 🪱 Today we’re able to develop and take the first worm-derived therapeutics into the clinic. The Aspen Institute #allergies #autoimmune #biotech

Did you know that bovine colostrum is the first milk of cows after calving. It's rich in immunoglobulins, lactoferrin, lysozyme, lactoperoxidase, growth factors and bioactive peptides. Colostrum has higher levels of protein, fat, vitamins, and minerals when compared to milk. This enables full development of the newborn calf in addition to some immunity against several pathogens. Immuron's proprietary process of vaccinating cows with specific vaccines generated against antigens for therapeutic targets ensures that the colostrum contains a high concentration of polyclonal antibodies and high concentrations of immunoglobulin G1 against the specified antigens. The technology can be applied to a variety of diseases. The Company's combined proprietary technology platform and process offers delivery within the gastrointestinal tract and can be used to target viruses or bacteria and neutralize the toxins they produce at mucosal surfaces. Interested in learning even more about our platform? Visit https://loom.ly/q_KfDj8! #BioInnovation #FutureOfHealth #GutHealthMatters #DigestiveWellness #ASX #IMC #Nasdaq #IMRN #Travel

The World Health Organisation’s Cancer Agency has formally classified PFOA and PFOS as “carcinogenic to humans” (Group 1) and “possibly carcinogenic to humans” (Group 2B), respectively. At an International Agency for Research on Cancer (IARC) meeting in France, a working group of 30 scientists from 11 countries finalised the evaluation. IARC noted ‘sufficient’ evidence for PFOA-linked cancers in experimental animals and found ‘strong’ evidence that PFOA could do so in exposed humans. These findings would probably put pressure on the UK government to follow the EU and introduce more stringent regulations aimed at limiting people’s exposure to PFAS. Read on in Food Safety Magazine: https://okt.to/WP4Fza #ScienceForASaferWorld #ForeverCheimals #PFASTesting

🧬mRNA Insider - Week 10    Today's mRNA Insider delves into the subjects of inhaled IL-12 mRNA for lung carcinoma treatment, mRNA-based protein supplementation to treat Fabry disease, and the potential of mRNA vaccines in controlling livestock diseases, underscoring the promise of mRNA technology in diverse medical and agricultural fields.   If you have any questions about mRNA or mRNA formulations in LNPs, feel free to contact us through the provided link https://lnkd.in/dyfmHhVg.   References: 1. Liu et al. https://lnkd.in/daAquzUD 2. Zhang et al. https://lnkd.in/evGbGfd6 3. Mahony et al. https://lnkd.in/e9fBshr9   #mRNA #LNP #mRNAdelivery #mRNAtherapy #IL12 #proteinreplacement #veterinarymedicine #RIBOPRO

#Rotavirus diarrhea-associated illness remains a #GlobalHealth concern, partly due to discrepancies in #Vaccine performance between high and low-middle-income countries. Next-generation vaccines could help bridge this efficacy gap. #MIP, North Carolina State University, and Stanford University scientists demonstrate the potential for a #Probiotic next-generation vaccine by evaluating the #Immunogenicity and efficacy of a novel recombinant #LactobacillusAcidophilus platform using an adult #Murine challenge model.🐭 Authors: Darby Gilfillan, Allison Vilander, Echo Pan, Yong Jun Goh, Sarah O'Flaherty, Ningguo Feng, Bridget Fox, Callie Lang, Harry Greenberg, Zaid Abdo, Rodolphe Barrangou, and Gregg Dean. #NextGenVaccine #rLA #Probiotics #VaccineEfficacy #CSUResearch

Antimicrobial resistance stands as a formidable global threat to #publichealth, creating an #antibiotics pipeline and access crisis according to the World Health Organization. In response, an open-source #drugdiscovery framework was employed to address the urgent need for novel antibiotics. The Open Source Antibiotics consortium synthesized and tested 147 compounds against Methicillin-Resistant Staphylococcus Aureus, identifying structure–activity relationships. This effort represents a great example of how collaborative and #openscience approaches can help discover new leads against high-priority pathogens and effectively manage a growing global health challenge. Read more: https://lnkd.in/gc2EXzJ4

✨ Porcine reproductive and respiratory syndrome (#PRRS) remains a formidable challenge for the global pig industry. In the absence of specific antiviral treatments for #PRRSV, #mRNA #vaccines play a crucial role in managing the disease.   ✨ A proper vaccination plan is essential for protecting swine farms from the entry and spread of diseases. Such a plan not only enhances profitability by reducing pig disease costs but also ensures the well-being of the animals and decreases the risk of zoonotic disease transmission.   ✨ The inclusion of #nanoparticles in vaccine compositions enhances antigen stability and immunogenicity, offers precise delivery, and allows for a gradual antigen release (as shown below). https://lnkd.in/gvC7Q3EG Jiangsu Synthgene Biotechnology Co., Ltd.-mRNA Raw Material,Phosphoramidites,Molecular Diagnostic Raw Material,Customized service (synthgene-bio.com)

New paper out! 🎉 Predictive tools to assess potential sensitizing capacity of (novel) food proteins, such as the in vitro models we develop in our group, should be able to distinguish by high allergenic and low allergenic proteins. In this paper we have worked together with several European groups to demonstrate that structural homologous tropomyosin proteins differentially affect epithelial barrier disruption and mucosal immune activation linking to their known differences in sensitizing allergenicity. https://lnkd.in/e6ncx-W6

We celebrate and welcome the approval of the Political Declaration on antimicrobial resistance (AMR) by United Nations member states during the meeting which took place yesterday, September 26th. Member states declaration can be summarised in a short paragraph: "The research and development pipeline for vaccines, diagnostics, therapeutics, especially antimicrobials and alternatives to the use of antimicrobials, to prevent and address antimicrobial resistance, especially antibiotics, are insufficient". It sounds very good and the list of commitments is amazing. We encourage governments to move forward and start to work on it, mainly in the funding mechanisms as well as to promote and accelerate public-private partnerships. #AMR #Antivirals #InfectiousDiseases #Antibiotics https://lnkd.in/e-PzchgP

500 million years of evolution... now helping us treat diseases? Worms might be the most surprising heroes in autoimmune treatment. Here's why... It sounds wild, but Andrea Choe, CEO of Holoclara Inc, shares the story that led her to work on worm-based medicine. She heard on a podcast about a man who walked barefoot in Africa to get worms to treat his illness... and it worked! Andrea also talks about the moment she first saw the dataset. It showed signs of how worms have been "talking" for millions of years. Today, Holoclara is the first biotechnology company to develop worm-based treatments. We're talking discovery of molecules derived from these worms. Which then could help with diseases like Crohn’s disease and allergies. Crazy, right? 🎥 Watch the full episode here: https://lnkd.in/ejsEEBcf