Hopemark Health’s Post

"We are afraid that in its current form, the paper and its conclusion are a disservice to patients needing opioids and to practising clinicians, and could contribute to promoting anti-opioid agendas, demonisation, phobia, and further unwarranted policies." #pain #acutepain #opioids #painmanagement #guidelines #scientificpublishing #opioidepidemic Asaf Weisman https://lnkd.in/gr3zRTH8

The answer to yesterday’s #ClinicalChallenge question is: D. Xylazine overdose has caused major toxicity consisting of coma, apnea, bradycardia, and hypotension after inhalation or intravenous administration with heroin or illicit fentanyl. However, compared with opioid overdose alone, overdose of xylazine and an opioid was associated with a lower risk of cardiac arrest or coma in one multicenter cohort study. Severe, necrotic skin ulcerations (picture 1) and skin abscesses have also occurred after repeated parenteral use. Xylazine withdrawal has been described but there are no established diagnostic criteria; clinical findings overlap with those seen in patients with opioid withdrawal. For more, see the #UpToDate topic on clonidine, xylazine, and related imidazoline poisoning: https://ow.ly/9Z9k50QeaMl #EmergencyMedicine #MedEd

Case Consult #3! "Improving Adherence and Persistence With Durable Anti-VEGF Therapies for nAMD". View all 3 NEW Case Consults here: www.eye-connect.org/namd #CME #FREECME #CMEMedicalEducation #ContinuingMedicalEducation #CMEOphthalmology

The symptoms of carpal tunnel syndrome can range from mild discomfort to debilitating pain, tingling, and numbness in the hand and wrist. If left untreated, it can lead to long-term nerve damage. Let Gladiator Therapeutics help you perform at your best without the distraction of discomfort. https://ow.ly/6koF50RyGFC #GladiatorTherapeutics #FIR #Patented #CarpalTunnel #CarpalTunnelSyndrome #WristPain #GladiatorMDWristDevice

#Fibromyalgia is a debilitating disease affecting 1 million Australians with daily #ChronicPain, fatigue, #SleepDisruption and #BrainFog, often badly undermining suffer's #MentalHealth. Tryptamine Therapeutics Ltd (Tryp Therapeutics) (ASX:TYP, OTC:TYPTF) CEO Jason Carroll joins Jonathan Jackson in the Proactive studio to discuss promising results from a Phase 2a clinical trial assessing TRP-8802, an oral #psilocybin formulation in conjunction with #psychotherapy, as a treatment for fibromyalgia. The trial achieved a #FullPatientResponse with all five patients treated experiencing strong improvements in pain severity, sleep, and the level pain interfered with their daily activities, and one patient reporting they'd recovered their sense of smell, which was lost during a COVID-19 infection in 2021. Watch the full interview on our website https://ow.ly/HUwR50SVu3S where you can also read more about the trial's results http://ow.ly/i4Ej105F6QN. #ASX #TYP #Biotech #Biopharmaceutcials #MentalHealth #PsychedelicAssistedTherapy #Psilocin

Intra-Cellular Therapies edges closer to FDA win for #Caplyta in #depression: Intra-Cellular Therapies has secured another win with positive topline results from a Phase III study evaluating Caplyta (lumateperone) as an adjunctive therapy in patients with major depressive disorder (MDD). In the trial, dubbed Study 502 (NCT05061706), a 42mg daily dose of Caplyta (#lumateperone) as an adjunctive therapy provided a 4.5-point reduction on the Montgomery-Asberg Depression Rating Scale (#MADRS) at week 6 compared to placebo, meaning the trial met its primary endpoint. The drug also met the key secondary endpoint of change from baseline on the Clinical Global Impression Scale for Severity of Illness (CGI-S) at week 6. https://lnkd.in/gJHRHVaQ

Discover the future of opioid detox with the S.T. Genesis from Speranza Therapeutics. This non-invasive device uses electrical nerve stimulation to rapidly ease withdrawal symptoms, empowering patients on their recovery journey. Learn more at the link in our bio. #technology #innovation #healthcare #addictionmedicine #hope

Ophthopedia Update:Top in glaucoma 2023: Association of medications with acute angle-closure glaucoma: The top Healio glaucoma-related items this year covered the association between acute angle-closure glaucoma and certain medications, as well as a discussion about a needed paradigm shift in the approach to glaucoma treatment. Check out the most popular glaucoma items from 2023 below. Study investigates association of drugs with acute angle-closure glaucoma A case-crossover study conducted on a large health care database in South Korea shed light on the association between acute angle-closure glaucoma and a number of prescription and nonprescription medications. Read more. BLOG: Glaucoma needs a

In patients with moderately to severely active ulcerative colitis, risankizumab improved the rates of clinical remission when used as an induction and a maintenance therapy. https://ja.ma/4frWycD

To simulate drug effects on the liver, we use DILIsym, a sophisticated software model widely used to predict liver safety, As predicted by DILIsym, our recent clinical PK/PD study showed all envisioned acute pain treatment regimens to be liver-safe. #OpioidCrisis #Inflammation #DILIsym