IDvet’s Post

From benign to dangerous pathogen : Mannheimia haemolytica a bacteria found in calves, adult bovine and sheep.   🦠Mannheimia haemolytica is reputed to be one of the most pathogenic pathogen among pasteurellaceae in cattle, which are the main bacterial agents involved in diseases of the deep respiratory tract of cattle.   🔃The bacteria transforms from benign into a dangerous pathogen under stress factors, mycoplasma, or viral co-infections. This evolution causes a rapid multiplication in the respiratory tract, releasing pro-inflammatory molecules and a Leucotoxin, which decimates white blood cells and leads to lung tissue destruction. This etiology may result in high mortality rate within 24 to 48 hours.   🐄Calf pneumonia not only impacts the economics of cattle operations but also poses significant welfare concerns globally. Detecting this bacteria early is crucial to prevent its devastating effects on cattle.   🔎Our ELISA kit detects specific antibodies of Mannheimia haemolytica in bovine sera or plasma, providing insights into the serological status of cattle and helping in disease prevention.   The kit uses ELISA technology to provide valuable information about their immune response to this pathogen, crucial for implementing appropriate treatment, effective prevention and control measures.   Find out more about this kit and our respiratory pathogens diagnostic range on our website. 👆   #AnimalHealth #VeterinaryDiagnostics #ELISA #RespiratoryDiseases

"This work shows that wastewater monitoring can provide an early warning for outbreaks likely to produce contributions to the sewershed outside of the expected human-associated inputs, including for animal outbreaks of diseases with zoonotic potential. In Potter/Randall County, retrospective testing shows that H5 was detectable in wastewater on Mar 1, 2024 - nearly a week before an unspecified disease was reported in dairy cattle in Texas (Mar 7) and several weeks before the causative agent was identified as H5N1 (Mar 25). Understanding and describing industry inputs into municipal wastewater, especially those that may be associated with contributions from animals, is critical both to identifying anomalies in influenza data from wastewater that do not relate to human disease, and identifying cases when wastewater can provide important, early warning data on outbreaks with zoonotic potential." https://lnkd.in/g7it_AwJ

🐄 Exciting News for the Cattle Industry! 🐄 Bovine Respiratory Disease (BRD) continues to pose a significant challenge in managing cattle health worldwide, impacting both dairy and beef sectors. But fear not, advancements in diagnostic strategies are on the horizon! The lack of standardized definitions has complicated the diagnosis and treatment of BRD, but with emerging technologies like imaging, biomarkers, and automated analysis, we are ushering in a new era of precision care for cattle. Curious to learn more about the latest developments in BRD diagnostics? Check out our new article providing a comprehensive exploration of BRD, its existing diagnostic strategies, and the potential of emerging field-based diagnostic technologies for timely and optimal care: https://lnkd.in/g7nzT3Fz. Stay tuned as the cattle industry embraces cutting-edge diagnostic tools to tackle BRD head-on, ensuring better outcomes for our animals. 🌟🐮 #BovineRespiratoryDisease #AnimalHealth #CattleIndustry #InnovationInAnimalHealthcare #BRDDiagnostics

Foreign animal diseases are a global threat to swine production with the potential for detrimental economic implications. Recently, researchers at the University of Illinois Urbana-Champaign received a three-year grant of $650,000 from the U.S. Department of Agriculture to develop sensitive, rapid, low-cost, and portable point-of-use biosensors to improve on-farm detection and surveillance of African swine fever virus. ASFV is a large DNA virus that infects swine and can result in a lethal hemorrhagic fever, spread rapidly to neighboring pigs, and cause excessive morbidity and mortality in swine populations. There currently is no effective vaccine or treatment for ASFV to help prevent infection and transmission. Further, detection of the virus is challenging because it relies on expensive offsite laboratory-based methods which often take too long for successful disease mitigation. https://lnkd.in/gaWBYkK5

We're happy to announce that we've successfully organized a comprehensive workshop on animal disease prioritization for the Department of Livestock Services. 🐄🐓🐖 At the heart of this workshop was the powerful One Health Zoonotic Disease Prioritization Tool (OHZDP), developed by US-CDC. This innovative tool, based on 𝐚𝐧𝐚𝐥𝐲𝐭𝐢𝐜 𝐡𝐢𝐞𝐫𝐚𝐫𝐜𝐡𝐲 𝐩𝐫𝐨𝐜𝐞𝐬𝐬 (𝐀𝐇𝐏), played a crucial role in helping us identify and prioritize the most significant animal and poultry diseases. Key Benefits of the OHZDP: ✅ Flexible tool, scalable to the local, national, or regional level and intended purpose ✅ Intended to remove bias ✅ Utilizes alternative disease data allowing diseases to be prioritized even in the absence of reliable prevalence data ✅ Provides outcomes in a timely manner. This prioritization will certainly help to set - ✔️ Different priorities for different stakeholders ✔️ Budget optimization ✔️ Prioritize surveillance activities ✔️ Evidence-based disease control priorities ✔️ Vaccination ✔️ Treatments/Medication ✔️ Determine disease elimination goals ✔️ Direct research activities ✔️ Improve livestock and poultry production and assure food security. If you would like to know about the tool, you can read: 1. https://lnkd.in/gs__8WzF 2. https://lnkd.in/gtbzaWsk

Farm animal diseases have a great health and economic impact. The overcrowded conditions and lack of hygiene, among other factors, make them very susceptible to various diseases, in addition to the possibility of leading to epidemic outbreaks that are difficult to contain. Diagnosis is essential to be able to treat animals correctly and quarantine them if necessary. It is also essential to detect possible diseases in new acquisitions. 👉 At Rekom Biotech, we design and produce high-quality and validated reagents for the in vitro diagnosis of farm animal diseases. Do not hesitate to take a look at our website to find IVD reagents for your assay development! #farm #animal #diseases https://rb.gy/dp4z4r

Recombinant protein MilA & IgG2 : an innovative serological approach against Mycoplasma bovis.   🧫Mycoplasma bovis is a pathogen causing various diseases affecting all ruminant species, and all production sectors.   M. bovis diseases can be difficult to diagnose and control because of inconsistent disease expression and response to treatments.   In addition to economic costs, there are important animal welfare consequences of M.bovis infections, given that the associated disease if often chronic and poorly responsive to treatment.   🧪Due to non-specific clinical symptoms and great variations in genotypes and pathogenesis, each disease caused by M.bovis requires a specific diagnostic approach and control measures.   👉Our new Monoscreen AbELISA M.bovis High Sensitivity features a unique recombinant MiLA / anti IgG2 combination which enables a high level of sensitivity as well as a remarkable capacity to discriminate negative vs positive animals.   🔎It offers a very low detection cut-off level and therefore enables the monitoring of seronegative status of herds, to be integrated into a biosecurity plan.   🧬It is particularly designed for serodiagnosis of M. bovis infections in young calves because the conjugate only recognizes IgG2, which is only generated by the calf in response to the infection. Where IgG1 of colostral origin from a mother previously exposed to M.bovis will not be recognized. Discover more on our website !   #animalhealth #veterinarydiagnostics #ELISA

Scientists report on four people in #Michigan who contracted #tuberculosis (TB) linked to wild #deer and domestic #cattle from 2019 to 2022, raising the total number of #zoonotic cases in the state to seven since 2002. A team led by physicians at Corewell Health East and the University of Michigan reviewed data and #Mycobacterium bovis cultures from the Michigan Department of Health & Human Services #TB database. They conducted interviews and compared whole-genome sequences of human isolates with a veterinary library of M bovis strains. The three confirmed and one probable human M bovis cases identified from 2019 and 2022 resulted in cutaneous disease, two cases of severe pulmonary disease, and one case of human-to-human spread. Those infected were a taxidermist, a woman who interacted with deer in the affected area, and a man with no obvious animal exposures and his female household contact. The three human isolates had zero to three mutations linked to M bovis strains circulating in local deer and cattle. M bovis continues to spread from deer to humans and cattle and poses a particular risk to people with weakened #immunesystems. M bovis is usually tied to TB in cattle, which can transmit the bacteria to humans through consumption of unpasteurized dairy products. The #bacteria cause disease that is indistinguishable from that caused by M tuberculosis, and common diagnostic tests cannot identify M bovis. https://lnkd.in/eM6WP-T2

🐄 Happy to share a recent publication from #FAO EMPRES on the rapidly evolving situation of influenza A(H5N1) in dairy cattle. Many thanks to the officials, veterinarians, researchers, and dairy producers who are working together to understand and control this emerging disease. Our hope is that this article pulls together information in a helpful way to support prevention and preparedness globally. https://lnkd.in/gQKwyjW3

#EcoSaludGlobal @USDA Today, the APHIS National Veterinary Services Laboratories made available 239 genetic sequences from the U.S. H5N1 clade 2.3.4.4b influenza virus recently found in samples associated with the ongoing highly pathogenic avian influenza (HPAI) outbreak in poultry and wild birds, and the recent H5N1 event in dairy cattle. APHIS routinely publishes influenza genetic sequence data on GISAID (the Global Initiative on Sharing Avian Influenza Data); however, in the interest of public transparency and ensuring the scientific community has access to this information as quickly as possible to encourage disease research and development to benefit the U.S. dairy industry, APHIS is also rapidly sharing raw sequence data to the National Institute of Health’s National Library of Medicine, National Center for Biotechnology Information. Sequences posted are from cattle, cats, chickens, skunk, racoon, grackle, blackbird, and goose.  APHIS will continue making additional raw genetic sequences available on a rolling basis at Home - SRA - NCBI (nih.gov); use the search term “ WGS of H5N1 ”.