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The study uncovers a pan-cancer T cell dysfunction program that predicts clinical non-response to checkpoint blockade in melanoma and highlights CXCR6 as a pan-cancer marker of chronically activated T cells.    The researchers used a computational approach to analyze diverse single-cell RNA sequencing datasets of 33,161 CD8+ T cells from 132 patients with 7 different cancer types.    The research also identifies a TCF1:CXCR6 regulatory axis that counterbalances PD1-mediated T cell suppression to support anti-tumor immunity.    #Dextramer® reagents were used to quantify tumor antigen-specific T cells in the mouse tumor models MC38 and B16.    Read the full article – find the link in the comments!🙌     #pancancer #singlecell #antigenspecificity #immunology #flowcytometry #checkpointinhibitors #immunotherapy 

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