Orna Therapeutics is pursuing in vivo delivery of CARs, which would eliminate the need for lymphodepletion and address the reliance of proximity to large cancer centers and the rising costs of cell therapies. Dr Robert Mabry, Orna’s CSO, shares how Orna is using circular RNA for the next generation of CARs. Read the interview here: https://lnkd.in/eRR8V_qy
Immuno-Oncology 360° Community News’ Post
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Pharmaceutical professional on Analytical Development and CMC for antibodies (mAbs), fusion proteins, cytokines, AAV gene therapy, LVV T cell therapy; CRO, CDMO management; IVD, RNAi, enzymes
Comprehensive landscape of Cell Therapy
𝐂𝐞𝐥𝐥 𝐓𝐡𝐞𝐫𝐚𝐩𝐲 𝐋𝐚𝐧𝐝𝐬𝐜𝐚𝐩𝐞 𝐢𝐧 𝐎𝐧𝐜𝐨𝐥𝐨𝐠𝐲 🚨 155+ cell therapy companies below focused on oncology and categorised by the following areas; - NK cells - T cells - Other 📈 Exciting to see NK cell players growing as well as the convergence of innovative start-ups when it comes to the other section, creating a captivating overlap on the Venn diagram! Huge credit to Sami Corwin, Ph.D. + William Blair for another fantastic piece as well as company reports and good analysis from Paras Sharma. P.S. - Want to stay ahead of the biotech revolution? Sign up for FREE to my 𝐂𝐆𝐓𝐰𝐞𝐞𝐤𝐥𝐲 newsletter and discover the newest companies, clinical updates and breakthroughs this week, here: https://lnkd.in/etZK5kzZ #celltherapy #oncology #biotech #CGTweekly
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Good overview to help navigate cell types in the Cell Therapy Oncology landscape.
𝐂𝐞𝐥𝐥 𝐓𝐡𝐞𝐫𝐚𝐩𝐲 𝐋𝐚𝐧𝐝𝐬𝐜𝐚𝐩𝐞 𝐢𝐧 𝐎𝐧𝐜𝐨𝐥𝐨𝐠𝐲 🚨 155+ cell therapy companies below focused on oncology and categorised by the following areas; - NK cells - T cells - Other 📈 Exciting to see NK cell players growing as well as the convergence of innovative start-ups when it comes to the other section, creating a captivating overlap on the Venn diagram! Huge credit to Sami Corwin, Ph.D. + William Blair for another fantastic piece as well as company reports and good analysis from Paras Sharma. P.S. - Want to stay ahead of the biotech revolution? Sign up for FREE to my 𝐂𝐆𝐓𝐰𝐞𝐞𝐤𝐥𝐲 newsletter and discover the newest companies, clinical updates and breakthroughs this week, here: https://lnkd.in/etZK5kzZ #celltherapy #oncology #biotech #CGTweekly
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Versatile & Fast learning professional | Proficient in Programming for Modeling, Docking, and Data Analysis | Expertise in Diverse Environments, Team Management & Handling Laboratory Experiments
The suggested mechanisms for apoptosis in cancer cells by using AgNPs, according to Xi-Feng Zhang, Z.-G. L., Wei Shen, and Sangiliyandi Guruanthan in their paper titled "Silver Nanoparticles: Synthesis, Characterization, Properties, Applications, and Therapeutic Approaches"- published in 2016. This Figure is drawn in BioRender
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Principal - Oncology - Oracle Life Sciences | Consulting | Commercialization | Research | RWE Data & Analytics
🎯 Evolution of Cell Therapy Development in Oncology 🎯 Cell therapies have come a long way. Here is a great interactive infographic tracking development, across different tumors types, through an evolving target landscape. (DOWNLOAD to enjoy the interactivity) #Oncology #Biotech #ClinicalTrials #cancermpact #oraclelifesciences
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It’s like seeing science fiction come to life! 🚀✨ Step into the future of cancer treatment with Julia Gilden, Senior Research Scientist at Promega. Uncover the potential and challenges in developing CAR-T drugs. 💡 Explore how the HiBiT Target Cell Killing Bioassay brings a whole new level of precision to measure CAR-T cell potency and effectiveness against tumors. https://lnkd.in/eqhzdvCR #CellTherapy #Immunotherapy
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Dive into our new blog to learn how researchers are coupling advanced live-cell imaging with physiologically relevant #organoid models for in vitro cancer drug testing. http://ms.spr.ly/6045lXfwz
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Sc.D.., Ph.D., Professor of Pharmacology (Tenured); Professor of Biomedical Sciences; President World Mitochondria Society; Editor-in-Chief J Liposome Research;
ACTIVE loading of vesicles with drugs results in an intra-vesicular drug concentration significantly higher than in the loading medium. For example, the remote loading of liposomes with doxorubicin via an ammonium gradient (the prototype of ACTIVE loading) yields liposomes with drug concentrations inside the liposomes >100-fold the drug level in the loading medium. I severely doubt any of the "active drug loading" methods listed in this paper are able to achieve that. Baring a special interaction of the drug with lipid membranes or components already inside EVs, the intra-vesicular drug concentration can never be higher than in the loading medium, neither by electroporation, sonication, detergent treatment, extrusion nor by freeze-thawing cycles. All these 5 methods lack a driving force leading to an ACCUMULUATION of the drug inside the vesicle. The term "active loading" is wrongly used in this paper. I am happy to be challenged on my opinion, I am open for any discussion and if I am wrong, I would be happy to stand corrected.
Exploring extracellular vesicles as a drug delivery system for cancer therapy: in this review article, Jiabing Lian at China Medical University and collaborators offered a comprehensive overview of extracellular vesicles, detailing their biogenesis and absorption mechanisms. Additionally, they explored current research efforts aimed at utilizing EVs as drug carriers, covering purification techniques, drug loading, and bioengineering for targeted delivery https://lnkd.in/eTCm_t4Z Their analysis highlighted the potential of EVs as versatile and effective tools for drug delivery, especially in cancer therapy. An article co-authored by Jin Wang and Bohang Yin #extracellularvesicles #exosomes #drugdelivery #cancertherapy #bioengineering #Vesiculab
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Business Development Director at Fortrea (formerly Covance, Labcorp). Supporting clinical development Phase I-IV for biotech companies
While uptake has been limited, cell therapy’s impact in cancer care is growing, and biotech companies have continued to invest in ways to improve it, such as through “off-the-shelf” options or by using different types of immune cells. Explore the current market for cancer cell therapies and what biotechs are working on next. https://lnkd.in/gYyYxWyH
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🚨 𝐂𝐞𝐥𝐥 𝐓𝐡𝐞𝐫𝐚𝐩𝐲 𝐟𝐨𝐫 𝐎𝐧𝐜𝐨𝐥𝐨𝐠𝐲 𝐋𝐚𝐧𝐝𝐬𝐜𝐚𝐩𝐞 166+ global cell therapy companies below focused on oncology and categorised by the following areas; - NK cells - T cells - Other 📈 It's exciting to witness the resilience and expansion of NK cell-focused companies and the emergence of innovative start-ups in the 'Other' category. This convergence creates a fascinating overlap on the Venn diagram of cell therapy innovation. Huge credit to 𝐒𝐚𝐦𝐢 𝐂𝐨𝐫𝐰𝐢𝐧, 𝐏𝐡.𝐃. + 𝐖𝐢𝐥𝐥𝐢𝐚𝐦 𝐁𝐥𝐚𝐢𝐫 for another fantastic piece as well as company reports. #celltherapy #oncology #biotech #CGTweekly
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🔬 Recent studies demonstrate the use of microcarriers for large-scale production of HEK293T cells—a challenging task when working with adherent cells. The research focuses on screening active compounds from Fructus evodiae targeting the FGFR4 receptor, which plays a key role in cancer therapy. By utilizing microcarrier technology, the study shows how drug screening can be more efficient and biomimetic, mimicking in vivo conditions for better results. Learn more about this innovative method and its applications on our website 👉: https://lnkd.in/gu6nj7zk Do you need help with large-scale expansion of HEK293T cells? Reach out to our panel of experts to help you adapt to microcarrier culture: info@smartmcs.com.au #HEK293T #CellCulture #Microcarriers #DrugDiscovery #CancerResearch #Biotech #ScalingScience
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