Yesterday we tested your knowledge on proteins that are epigenetic readers that bind to chromatin and enhance target gene expression. If you guessed the BET protein, you are correct! Incyte is investigating a BET inhibitor in myeloproliferative neoplasms (MPNs). https://bit.ly/4d9XoJ8
Incyte Medical’s Post
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🎯 Our epigenomic controllers are designed with unparalleled specificity. Each DNA-binding domain is engineered to target a single epigenomic zipcode or EpiZip, a unique ~20 nucleotide sequence, ensuring precise regulation of gene expression. Discover how we're harnessing the power of specificity to unlock new therapeutic possibilities: https://bit.ly/3xiJzZo
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Learn about the flexible side of #singlecell in this blog, covering FAQs about sample prep for Chromium Single Cell Gene Expression Flex. Should I start with fresh, frozen, or fixed samples? How can I profile #FFPE? Any best practices for storage and transport? QC considerations, stopping points? Read on to explore all of these questions and find out how to run single cell assays on your schedule.
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⏲️ #EpigenomicControllers (ECs) can be engineered to durably upregulate and downregulate gene expression, and their effect can be tailored to last days, weeks, or months. This key attribute holds significant potential to optimize therapeutic regimens for safety, efficacy and dosing flexibility. Explore the capabilities and benefits of ECs here: https://bit.ly/3xiJzZo
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Screening lots of variants? Don’t be afraid to pool them and take it to the max without the cost per fragment limiting those numbers too much 👍 Come and chat more about Twist Bioscience latest boundary push on oligo length upto 500 nt #MPRA #antibodydiscovery #peptideengineering #proteinengineering #CRISPR
Innovate with Twist Multiplexed Gene Fragments! Achieve a high diversity of antibody variable domain regions without the cost normally associated with synthesizing variable regions individually. See what researchers are saying: “A-Alpha Bio harnesses synthetic biology and machine learning to measure, predict, and engineer protein-protein interactions. With the expanded coding region of Twist Multiplexed Gene Fragments and the scalable pooled format, we’re able to design and assemble antibody libraries that help us progress our R&D efforts.” ~Danielle Van Citters, A-Alpha Bio Read more about Twist Bioscience Multiplexed Gene Fragments here: https://lnkd.in/gTMrSJ5h
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Supporting biosciences to enable scientific creativity and make for innovative therapies.
Our multiparameter GeneOptimizer goes beyond codon optimization to increase mRNA stability and protein expression. This webinar illustrates the highest standards in protein expression on the market, from gene synthesis to expression in our Expi systems.
Webinar—Complete Workflow Solution from Gene-to-Protein | Thermo Fisher Scientific - US
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New! Faustovirus Capping Enzyme adds Cap-0 or Cap-1 (when used with mRNA Cap 2′-O-Methyltransferase) to the 5′ ends of RNA for efficient gene expression. Broader temperature range than other capping enzymes. Suitable for challenging 5’-sequences. Learn more: https://ow.ly/vrFW50S1hnz #RNA #GeneExpression #RNAtherapeutics
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Once all the variants have been identified, each variant is correlated with the altered amino acid sequences they encode. Using computerized tools, the translated peptides are generated from the DNA data. Using data on the translated peptides, neoantigen prediction software can be used to calculate the binding affinities of human leukocyte antigen (HLA) Class I and Class II (in humans these are encoded by the major histocompatibility complex (MHC) gene) to the translated peptides.
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I am delighted to share our new findings on Endometriosis: 'Increased Gene Expression of LITAF, TNF-α and BCL6 in Endometrial Tissues of Women with Endometriosis: A Case-Control Study' https://lnkd.in/gS2SWYgE
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Mannervik discusses their findings and highlights the need for a better understanding of epigenetic substrates to accurately link histone modifications and chromatin state to cellular processes and disease etiologies. Read the Outlook: ➡️ https://lnkd.in/eKTbVQ6m
Crain et al. show that the H4K20 methyltransferase Set8 and H4K20me1 reader L(3)mbt regulate gene expression and occupy chromatin through H4K20me1-independent mechanisms. Learn more here: ➡️ https://lnkd.in/ezYQwivg
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20000+ Connections. Currently Animal Welfare Consultant & Advisor Being Specialized Member of AWSDF Gurgaon.
How a Human Starch Gene and a Gut Bacterium are Connected Now scientists have identified a connection between variations in the number of copies of a gene, AMY1, which codes for an enzyme called amylase, and certain bacteria in the gut and mouth. The amylase enzyme acts in the saliva to break down starches. When people have many copies of the AMY1 gene, they tended to have a certain gut and mouth bacteria profile. https://lnkd.in/d_ETR8cT
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