Attending ASGCT? Check out our presentation titled “Compact Epigenetic Modulators for CRISPR Mediated Persistent Gene Activation,” where Epic Bio’s Daniel Hart PHD, Head of Technology Development, will demonstrate our ability to persistently activate genes using our Gene Expression Modulation System (GEMS). Read the abstract here: https://ow.ly/ZtYN50Rszzp #EpicBio #ASGCT2024 #GeneticMedicine #epigenetics

Zhu et al. provide structural insight into how IκBζ, NFκB-p50 and RelA interact to regulate target gene expression. Learn more here: ➡️ https://lnkd.in/ezA_xGx5 Also see https://lnkd.in/e87YFENx for how IκBζ and NFκB-p50 co-regulate inflammatory gene expression in macrophages.

In the realm of genetics, a repressor stands as a protein tasked with binding to a distinct DNA sequence, often nestled within the regulatory segment of a gene. Its primary function lies in thwarting the expression of said gene. This function operates through a mechanism of negative regulation, wherein the repressor acts as a barrier, impeding the access of transcription factors to the DNA. Consequently, this obstruction halts the transcription process, preventing the conversion of the gene into mRNA and, consequently, hindering protein synthesis.

For many scientists context is critical to understanding and with that in mind we take a deeper dive into chromatin regulation of insulin gene expression in diabetic donors. Read about the study and editorial https://lnkd.in/gDinp537 https://lnkd.in/gC6Jbjf3

🔐 Unlock the secrets of gene expression with EIRNA Bio's #RiboSeq services! 👀 Dive deep into the translational landscape of your samples and discover the intricacies of mRNA translation. #RibosomeProfiling #HarnessingTranslatomics 🔎https://ow.ly/PLJM50QH67n

Creative Biogene offers diverse dsRNA controls as reliable positive controls for precise dsRNA assays. These controls empower researchers to induce RNA interference, study gene functions, and facilitate gene silencing studies. https://lnkd.in/gq2mzPVK

In the realm of genetics, a repressor stands as a protein tasked with binding to a distinct DNA sequence, often nestled within the regulatory segment of a gene. Its primary function lies in thwarting the expression of said gene. This function operates through a mechanism of negative regulation, wherein the repressor acts as a barrier, impeding the access of transcription factors to the DNA. Consequently, this obstruction halts the transcription process, preventing the conversion of the gene into mRNA and, consequently, hindering protein synthesis.

🧬 Discover the power of reference genes in gene expression analysis! This blog dives into why RPLP0 is a top choice for RT-qPCR assays. Learn its stability across tissues and species. Read now! https://hubs.li/Q02yfZQz0 #GeneExpression #RTqPCR

⏲️ #EpigenomicControllers (ECs) can be engineered to durably upregulate and downregulate gene expression, and their effect can be tailored to last days, weeks, or months. This key attribute holds significant potential to optimize therapeutic regimens for safety, efficacy and dosing flexibility. Explore the capabilities and benefits of ECs here: https://bit.ly/3xiJzZo

📈 I recently completed a project exploring the relationship between SEX 👨🏽🦱👩🏽 and GENE EXPRESSION🧬 in adipose tissue. Using LINEAR REGRESSION, I analyzed adipose tissue data, to explore the association between sex and gene expression. I focused on one specific gene- SALL1, and calculated key metrics like the P-value and Beta providing insights into the relationship between the variables. Check out the full project 👉 [https://lnkd.in/duKUWq8E]