INNOVIT - Italian Innovation and Culture Hub’s Post

#Bacteria in #gut #microbiomes can protect each other from drugs, but this protection fails at higher concentrations. #Drug-sensitive bacteria can develop #resistance when part of microbial communities, utilizing cross-protection mechanisms. 24 September 2024, Cell. DOI: 10.1016/j.cell.2024.08.037 https://lnkd.in/dp3r84q4

Bacteria are survival experts! 🦠 One of their most formidable weapons against antibiotics is enzymatic inactivation. They produce specialized enzymes that act like molecular scissors, snipping away at antibiotic molecules before they can do their damage. This clever defense mechanism is a major contributor to the global antibiotic resistance crisis. It's like an arms race between humans and bacteria, with them constantly evolving new ways to outsmart our defenses. Understanding these enzymes is crucial for developing new antibiotics and alternative therapies. Together, we can combat superbugs and protect public health. #antibioticresistance #bacteria #enzymaticinactivation #microbiology #science #healthcare #innovation #superbugs #drugdiscovery

Our most exciting post yet! 💫 🔈 NeoPeptix 🔈 - Our Solution to Cryptococcus neoformans In our last post, we highlighted the critical need for innovative solutions to combat Cryptococcus neoformans, the #1 fungal pathogen of concern. If you missed it, be sure to check it out! Over the past few months, we have been rigorously developing our lead candidate, NeoPeptix, as a potential peptide drug against this dangerous fungus. We're thrilled to show you one piece of the puzzle in this post. Check out how NeoPeptix outperforms the current leading treatment, fluconazole. These are nutrient-rich plates showcasing C. neoformans colonies in the presence of NeoPeptix versus fluconazole. Our solution is 40x more potent, with no human cell toxicity or hemolytic activity. 🙌 Next up are animal studies! We are eager to continue de-risking this peptide. Stay tuned for more updates. Together, we can make a difference. 🌍 #HealthcareInnovation #FungalInfections #InfectiousDisease #CryptococcusNeoformans #NuvoBio #MedicalResearch #GlobalHealth #InnovativeTreatments #PublicHealth #PeptideTherapeutics

#antibacterial #amr #ESKAPE . It is always extremely satisfying to see that independent researchers confirm your discoveries. Two days ago, Jatin Chadha Gaurav Moudgil and Kusum Harjai confirmed our previous work about synergies between terpinene-4-ol and α-terpineol - two #natural molecules - to fight bacterial #pathogens https://lnkd.in/dpEi3sct For our initial work, see https://lnkd.in/dMwwr2_c This publication is very exiting for us since it allows to convert "it is suggest that…” to “it is demonstrated that…” (2 independent teams based in different geographical areas using different techniques obtain the same results). In details, the authors focused on Pseudomonas aeruginosa , one of the six ESKAPE = most highly virulent and #antibiotic #resistant bacterial pathogens (including multi-drug resistance = #MDR ). The authors : -       Confirm the synergy between terpinene-4-ol and α-terpineol on P.a.; -       terpinene-4-ol + α-terpineol inhibit #quorum sensing (QS); -       combination of the two molecules has anti #virulence potential (reduce hemolysin, pyocyanin, pyochelin, and total protease production in P. aeruginosa). Important: the use of a combination of terpinene-4-ol +  α-terpineol for their synergistic antibacterial effects is protected by a #patent granted this summer 😉 For more details and discussions, send me a PM.

This review concludes that the wild-type endolysins encountered persistent challenges in raw milk and in vivo settings, causing a notable shift in the field towards the engineering of endolysins. Lead candidates that display robust lytic activity are nowadays selected from screening assays that are performed under these challenging conditions, often utilizing advanced high-throughput protein engineering methods. Overall, these recent advancements suggest that endolysins will integrate into the antibiotic arsenal over the next decade, thereby innovating antimicrobial treatment against bovine mastitis-causing streptococci and staphylococci. Balganesh Tanjores Vivek Daniel Paul Sanjeev Saravanan Anisha Ambady https://lnkd.in/eQTdUaK7

Bacteria develop resistance against most #antibiotics in clinical use after just 3 days of exposure to small doses of ciprofloxacin. Interestingly, in the presence of antibiotics these resistant bacteria replicate but shrink in size: https://lnkd.in/eviFNtPj

Discover the dynamic world of Lipopolysaccharides (LPS) in our latest tech article! Delve into the structure, function, and innovative research applications of this key component in Gram-negative bacteria. From fortifying bacterial defense to advancing vaccine development and #DrugResearch, LPS plays a pivotal role.

Discover the dynamic world of Lipopolysaccharides (LPS) in our latest tech article! Delve into the structure, function, and innovative research applications of this key component in Gram-negative bacteria. From fortifying bacterial defense to advancing vaccine development and #DrugResearch, LPS plays a pivotal role.

Discover the dynamic world of Lipopolysaccharides (LPS) in our latest tech article! Delve into the structure, function, and innovative research applications of this key component in Gram-negative bacteria. From fortifying bacterial defense to advancing vaccine development and #DrugResearch, LPS plays a pivotal role.

Understanding how pathogens degrade fungicides can lead to more sustainable #turf management practices, potentially reducing the reliance on chemical treatments and fostering the development of integrated pest management strategies. #TurfManagement