International Journal of MS Care (IJMSC)’s Post

"In 100 [individuals with #MultipleSclerosis], the rate of amyloid-β plasma biomarker positivity was approximately half the rate in 300 non-MS controls matched on age, sex, apolipoprotein E proteotype, and cognitive status. Interestingly, most MS patients who did have amyloid-β pathology had features atypical for MS at diagnosis. These results support that MS is associated with reduced #Alzheimer disease risk..." https://lnkd.in/gV7k5jUb Matthew Brier

"Our results provide evidence supporting the value of [people with #MultipleSclerosis] engaging with multimodal healthy #lifestyle behaviors, particularly a healthy #diet and regular #PhysicalActivity, with the best health outcomes observed when engaging with ≥4 behaviors. Findings are potentially relevant to common queries in clinical practice regarding how pwMS can improve their future outcomes via facilitating self-management through lifestyle modifications." https://lnkd.in/geZPjqr8 Maggie Yu, Jeanette Reece

"We showed that the classification of [#OpticNeuritis] is highly dependent on #color vision testing, and a skilled evaluation of the relative afferent #PupillaryReflex. When we amended the 2022 [international consensus criteria for optic neuritis] ICON, we could slightly improve its performance. Therefore, we suggest a potential addendum to the 2022 ICON: patients with painful monocular vision loss in whom RAPD or dyschromatopsia were not documented at presentation, be included as ON if two additional diagnostic paraclinical criteria with one being MRI optic nerve abnormalities are present." 

"Never-words are conversation stoppers. They seize power from the very patients whose own voices are essential to making optimal decisions about their medical care. #Clinicians should instead aim to start #dialogue, by inviting honest, thoughtful inquiries and responses from #patients and families." https://lnkd.in/gdJhgivw Rana Awdish, Gillian Grafton, Len Berry

#NeuroArtFriday #ChronicIllness #DoAllTheThings Art by https://lnkd.in/dY-UxCmE

#NeuroArtFriday #BlueMoon #photography

Study: Treating #obesity may be crucial to managing disease progression in #women with #MultipleSclerosis. Study shows that it worsens symptoms & also alters immune responses uniquely in women, driven by factors such as increased adiposity & influence of #hormones, eg, #estrogen. https://lnkd.in/g2aRiyy9 Brendan Cordeiro, Shannon E. Dunn

"It’s heartbreaking to have this conversation and to say, 'We want to get you some help,' and to have the person say, 'I know it’s not an ideal relationship, but I am terrified [that you’ll] do something that takes my caregiver away. What am I going to do? Can you give me a new #caregiver?'…So that’s a tricky #ethical situation, too, because we’re mandated to report #neglect, and maybe that’s what we have to do….I think we can perhaps all understand that feeling that they don’t want to lose the good parts of what they have. I don’t know the answer to that one." ~Elizabeth Morrison-Banks Multiple Sclerosis and Abuse: A Conversation With Elizabeth Morrison-Banks and Suzanne Britt https://lnkd.in/gy7MxSZr

"Dr. Michael Levin and team discovered a protein called ‘heterogeneous nuclear ribonucleoprotein A1’ or ‘hnRNP A1’ that does not function properly in [#MultipleSclerosis]. Malfunction of hnRNP A1 causes nerve fibre damage contributing to #neurodegeneration, and in turn, disability in people with MS. In this study, the researchers will synthesize and screen for small molecule treatments that can rescue the function of hnRNP A1 and reduce nerve fibre damage in animal models of progressive MS."