International Stereotactic Radiosurgery Society (ISRS)’s Post

We've seen fantastic progress in HCL treatment, from initial surgeries to remove the spleen to today's cutting-edge therapies. During a recent HCLF webinar, Dr. David Hermel from the Scripps Clinic discussed work at Scripps Clinic to study a chemotherapy-free treatment for patients with classic BRAF-positive HCL. Therapies for HCL have evolved over the years, from splenectomy to interferon-based therapies and Cladribine-based therapies. The discovery of BRAF mutations in most classic HCL cases has opened up new possibilities for treatment, leading to BRAF inhibitors like Vemurafenib, which have been effective in treating other cancers, like melanoma. Materials from Dr. Hermel's May presentation are available on the HCLF website (including transcripts, slides and trial links) here: https://lnkd.in/guG8raYn

Dear Friends, this Gentle Lady 38 YRO has strong familiarity for breast cancer and has a Fibroadenoma in her LT breast (with bioptic confirmation at the 1st exam). This is its behaviour in 1 year, followed both with FFDM and with Multiparametric US. All the features show a great stability both in echogenicity and in a low vessels’ density. To be outlined the great stability also in the nodule/fat stiffness ratio in 1 year both at Strain Elastography (1,21 vs 1,27) and at Shear Wave Elastography (2,9 vs 2,1). To be understood why: § At Strain Elastography the stiffness ratio (1,21-1,27, stable in 1 year) is different from the value measured at Shear Wave Elastography (2,1-2,9) § In 1 year at Shear Wave Elastography the mean stiffness of the nodule changes from 33 kPa to 17 kPa and also the stiffness ratio changes from 2,9 to 2,1 (while at Strain Elastography no significant changes in Strain Ratio are found in 1 year).

Dear Friends, this Gentle Lady 38 YRO has strong familiarity for breast cancer and has a Fibroadenoma in her LT breast (with bioptic confirmation at the 1st exam). This is its behaviour in 1 year, followed both with FFDM and with Multiparametric US. All the features show a great stability both in echogenicity and in a low vessels’ density. To be outlined the great stability also in the nodule/fat stiffness ratio in 1 year both at Strain Elastography (1,21 vs 1,27) and at Shear Wave Elastography (2,9 vs 2,1). To be understood why: § At Strain Elastography the stiffness ratio (1,21-1,27, stable in 1 year) is different from the value measured at Shear Wave Elastography (2,1-2,9) § In 1 year at Shear Wave Elastography the mean stiffness of the nodule changes from 33 kPa to 17 kPa and also the stiffness ratio changes from 2,9 to 2,1 (while at Strain Elastography no significant changes in Strain Ratio are found in 1 year).

In May 2024, the National Institute for Health and Care Excellence (NICE) published three new Interventional Procedures Guidance concerning selective internal radiation therapy for liver metastases, endoscopic duodenal mucosal resurfacing in type 2 diabetes, and image-guided percutaneous laser ablation for liver tumours, and one Diagnostics Guidance on tumour profiling tests to guide adjuvant chemotherapy decisions in early breast cancer: https://lnkd.in/eRrG5n38

In May 2024, the National Institute for Health and Care Excellence (NICE) published three new Interventional Procedures Guidance concerning selective internal radiation therapy for liver metastases, endoscopic duodenal mucosal resurfacing in type 2 diabetes, and image-guided percutaneous laser ablation for liver tumours, and one Diagnostics Guidance on tumour profiling tests to guide adjuvant chemotherapy decisions in early breast cancer: https://lnkd.in/eqPqgMXA

🏥 Sirtex Medical Limited unveils SIR-Spheres FLEXdose SELECT Delivery for Y-90 therapy SIR-Spheres FLEXdose SELECT introduces a new method for delivering precise Y-90 selective internal radiation therapy to treat liver tumours originating from primary colorectal cancer. SIR-Spheres are a medical device used in selective internal radiation therapy. It is specifically indicated for use in conjunction with intra-hepatic artery chemotherapy (IHAC) using FUDR (Floxuridine). Read more online: https://lnkd.in/e78WcWQX 📰 Follow Medical Device Developments to receive the latest medical device news daily and to subscribe to our weekly newsletter #MedicalDeviceDevelopments #medicaldevices #medicalmanufacturing

⚡️ New insights on PD-L1 expression in muscle-invasive urothelial carcinoma 🔘 This study highlights the importance of precise PD-L1 testing for immunotherapy. Key factors include selecting well-preserved tissue, using the appropriate antibody and staining platform, and ensuring clear, comprehensive reporting for tailored immunotherapy approaches. #BladderCancer #Immunotherapy https://buff.ly/4hal2If

🍉 Innoblative Announces Successful First-in-Human Use of its Novel Electrosurgical Device for Breast Cancer Treatment Innoblative’s SIRA device aims to overcome these challenges and offer a better treatment option for BCS candidates. Its single-use, disposable applicator is designed specifically for intraoperative ablation of soft tissue, including potential residual cancer post-lumpectomy. With a unique spherical shape, the SIRA electrode circumferentially delivers radiofrequency (RF) energy to the entire cavity and yields reproducible ablation depths to provide greater confidence of a consistent thermal effect. Read more online: https://lnkd.in/eQ6PxmsR 📰 Follow Medical Device Developments to receive the latest medical device news daily and to subscribe to our weekly newsletter #MedicalDeviceDevelopments #medicaldevices #medicalmanufacturing

Help your patients relieve their challenging BPH symptoms with a minimally invasive procedure. Following the UroLift System procedure, most patients experience minimal downtime (1) and benefit from the lowest catheterization rate of leading BPH procedures. (1-6) See this example of the UroLift System with Advanced Tissue Control (ATC) successfully creating an open urethral channel. 1. Shore, Can J Urol 2014 2. Roehrborn, Can J Urol 2017 3. Bachmann, Eur Urol 2013 4. McVary, J Urol 2016 5. Mollengarden, Prostate Cancer Prostatic Dis 2018 6. Das, Can J Urol 2019

🚨 **Early Invasive Melanoma: A Stark Reminder of the Importance of Regular Skin Checks** 🚨 Sharing this crucial video today of an early invasive ( 0.75mm Beslow ) melanoma that developed in under 18 months. This rapid progression underscores the importance of regular skin checks and early detection. 🎥 Melanoma can progress rapidly, making early diagnosis essential for effective treatment. This highlights the crucial role of both advanced skin cancer training and modern technology in achieving the best outcomes. Clear Signs Seen in the Dermoscopy: - Chaos ( multiple colors and patterns) - Irregular border - *********White lines ********* #SkinHealth #MelanomaAwareness #EarlyDetection #BendigoSkinDoctors