Ionis Pharmaceuticals, Inc.’s Post

🎉 Exciting news! Our team's latest publication in the Journal of Thrombosis and Thrombolysis delves into the intriguing link between primary hyperparathyroidism and acute venous thromboembolism. Using NIS data, we found that patients with primary hyperparathyroidism were twice as likely to experience Acute VTE (OR: 2.1 [1.08-4.1]; p<0.025) compared to counterparts without primary hyperparathyroidism. Dive into our findings and join the conversation on this fascinating connection! #Research #Thrombosis #Hyperparathyroidism #VTE Georges Khattar

Check our new publication about using PET-scan in diagnosis of non-bacterial thrombotic endocarditis (NBTE) published in the #springer - affiliated Egyptian Heart Journal! NBTE represents a rare condition of patients who, most often, suffer from connective tissue disorders and malignacies. In our paper, we present a case of occult malignancy and explain the use of PET-scan in guiding our treatment strategy. DOI: https://lnkd.in/duxcDMu3

Don't miss the recent research in the Journal of Critical Limb Ischemia, "Outcomes of Reintervention in Percutaneous Deep Venous Arterialization." This study was performed to describe the outcomes of reintervention procedures for a stenotic or occluded percutaneous deep venous arterialization (pDVA) and to compare outcomes following pDVA in patients not requiring repeat intervention. Learn more: https://okt.to/vDTmgj #CLI #research

Hong W, Zippi M, Wang G, Jin X, He W and Goyal H (2024) Editorial: Immune dysfunction in acute pancreatitis: from bench to bedside research. Front. Immunol. 15:1462563. doi: 10.3389/fimmu.2024.1462563

Sometimes two teams are working on similar topics, without knowing. A recent publication in The Lancet happened to be comparable to an article previously published by our team. See their reactions via the correspondance published on the journal's website. https://lnkd.in/djt_E8Fb The studies compared can be found here: https://lnkd.in/dr7E7ub8 https://lnkd.in/dj5xyf4h #clinicalstudy #clinicalpharmacology #teamwork #OpenDiscussion

【Exertional Rhabdomyolysis Induced Acute Kidney Injury: A Case Report and Literature Review】 Full article: https://lnkd.in/gag2HsuK (Authored by Yu Zhang, from The Second Hospital of Tianjin Medical University, China.) The exRML (#exertional_rhabdomyolysis) is a pathophysiologic condition of skeletal muscle cell damage and breakdown associated with high intensity or prolonged exercise, normal exercise under extreme circumstances, or sudden and excessive skeletal muscle contraction. This paper presents a case of an elderly patient with exRML induced #acute_kidney_injury (AKI) and the key treatment process and reviews relevant literatures. #Serum_Creatine_Kinase #Myoglobin 

The diagnosis of ✅Warm Autoimmune hemolytic anaemia / warm-reactive AIHA is made if ✅BOTH of the following are present : 🔑Evidence of hemolytic anemia (anemia, high indirect bilirubin, high LDH, low haptoglobin) + 🔑Direct Coombs Test (DAT) positive for immunoglobulin G (✅IgG). Presence of numerous spherocytes on peripheral blood smear 🩸 are supportive finding. #pathology360 #WarmAIHA #medicos #doctor #healthcare ; Associate Professor Dr Kishore G Banerjee, MD.

The manifestation of an immune response can result in #ocular inflammation impacting study duration, power, and the ability to meet objectives. Using immunosuppression can help mitigate inflammatory impact but may not completely quench the response. In this presentation, we explore the ethical and scientific considerations for using immunosuppression in non-clinical ocular studies and the benefits, concerns, and strategies for its use. https://okt.to/RSk7fF

♤ Meta- Analysis Published We aimed to evaluate the efficacy and safety of the intensive BP target (< 140 mm Hg) versus the standard BP target (< 180 mm Hg) after EVT for acute ischemic stroke. There was no difference between intensive BP and standard BP targets regarding the National Institutes of Health Stroke Scale (NIHSS) change after 24 h. However, the intensive BP target was significantly associated with a decreased risk of excellent neurological recovery (mRS ≤ 1), functional independence (mRS ≤ 2) and independent ambulation (mRS ≤ 3). https://lnkd.in/e8WFuKWW