International Sport and Exercise Nutrition Conference’s Post

Interesting Seminar According to Giovanna Bratti: “FISH is important from a diagnostic and prognostic point of view, and above all FISH is important due to the therapeutic indicators it provides”, she says. Join this Caresphere Academy course with Dr Giovanna Bratti here https://lnkd.in/eskJhGXE to learn more and dive deeper into the world of FISH 🐟 #FISH hashtag #CaresphereAcademy hashtag #WebinarRecording hashtag #SysmexBNL

I am really looking forward to this seminar with Ina Schuppe Koistinen and Nina Pendergraph, Ph.D. on the link between Skin Microbiome and eczema. Bio-Me

I'm pleased to see the updated USG Dual Use Research of Concern (DURC) policy better clarifies review and oversight of pathogen research. I found it interesting that the 2024 version seems to take a stronger stance on research institutions that do not receive federal funding compared to the 2015 policy: 2015: "Institutions that do not receive USG funds for life sciences research... are not subject to oversight as articulated in this Policy; however, they are strongly encouraged to implement internal oversight procedures consistent with the culture of shared responsibility underpinning this Policy."   https://lnkd.in/gF7hXNxt 2024: "Research institutions that do not receive any federal funds for life sciences research... are strongly encouraged to implement oversight procedures consistent with the culture of shared responsibility underpinning this Policy. The U.S. government will consider additional approaches outside of this Policy for promoting use of these or similar oversight procedures by research institutions that conduct life sciences research and do not receive federal funding." https://lnkd.in/geXQub7t

This is an important, if rather uncomfortable, read about the apparent failure to learn about how to manage pandemics. What we can't ignore is that the way the U.S. handled this Covid pandemic was itself a failure to learn. See this insightful insider account by Dan Diamond - "Inside America’s 2-Decade Failure to Prepare for Coronavirus": https://lnkd.in/dZDRvKRN So another way to look at this consistent multi-decade experience is through the systems thinking heuristic coined by Stafford Beer "POSIWID" - The Purpose Of a System Is What It Does. As Beer advised, there is "no point in claiming that the purpose of a system is to do what it constantly fails to do." If we use this systems thinking frame of reference, what is the purpose of a system that demonstrates repeated & potentially catastrophic "failures" relating to pandemics? (These articles are US focused but much the same could be said for the UK & perhaps other countries too?) Paul Barnett Mark Thomas UK Covid-19 Inquiry Paul Lee Robert Eccles Rick Bright Rick Alexander Amy Maxmen Kai Kupferschmidt Dr Mike C Jackson OBE

Interesting webinar with presentations from Roel Vermeulen and Hubert Dirven on Micro- and Nanoplastics and Public Health 👇

Reminder, happening tomorrow! This free seminar is open to anyone who wants more education regarding treatment of complex UTIs.

Out of 27 'breakthroughs' reported in the UK national press, only 1 resulted in human benefit. A study by Cruelty Free International investigated whether highly publicised animal-based experiments had led to any new treatments, 25 years on. The results are clear. 💬 "Overspeculation and exaggeration of human relevance was evident in all the articles examined. Of 27 unique published ‘breakthroughs’, only one had clearly resulted in human benefit. 20 were classified as failures, 3 were inconclusive and 3 were partially successful." Have a read 👇 https://lnkd.in/edacYZTt #AnimalFreeScience #MedicalResearch #Research

PBPK Modeling Demonstrates That a Time Exposure Adjustment is Unnecessary for an Acute Manganese Health Guideline For the purpose of resolving uncertainty in determining an acute manganese inhalation toxicity criterion, ToxStrategies’ Camarie Perry, Ann Holbrow Verwiel, Tammie Covington, and Deborah Proctor used the most current published PBPK model for manganese to confirm that a time-adjustment factor is unnecessary when extrapolating animal bioassay exposure conditions for assessing acute (24-hour) human exposure, including among potentially exposed children. This recently published work (https://lnkd.in/gmKxQHnJ) expands upon a previous publication (https://lnkd.in/g39G6KDS) by ToxStrategies scientists and demonstrates that a proposed 4-fold time adjustment factor is not necessary to ensure protection of public health.

Explore the profound impact of in utero stress on animal development in our latest episode, featuring Dr. Jimena Laporta. Learn how stress signals experienced by a fetus, particularly due to heat, can trigger methylation and tissue structure changes. These changes are not just responses but adaptations, signaling to the animal that it's in a challenging environment. Tune in on our major platforms to delve deeper into this intriguing aspect of dairy science. https://lnkd.in/d79uGG7C

How safe is PFOA for humans? A recent study attempted to estimate the dose of PFOA that does not pose a risk to human health. This challenging goal is complicated by the large number of epidemiological studies with highly variable results, as the authors point out. A team of 24 scientists from eight countries reviewed the relevant data and independently developed ranges of estimated safe doses of PFOA. The scientists concluded that the available epidemiological information is insufficient to provide a reliable basis for assessing a safe human dose of PFOA. Using dose-response data from five studies of laboratory animals exposed to PFOA, the researchers estimated that PFOA doses between 10 and 70 ng/kg per day are not hazardous to human health. https://lnkd.in/d9rkAbcB While I agree with the researchers that deriving safety estimates from epidemiological studies is problematic, I disagree with their conclusions based solely on animal studies. In fact, PFOA bioaccumulates in the human body and persists much longer than it does in laboratory animals. In addition, the response of the PFOA receptor, PPAR-alpha, differs between laboratory rodents and humans. #pfas #foreverchemicals #bioremediation #enzymes #health #riskassessment