Ishaq A Viringipurampeer’s Post

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Scientist | Target Discovery & Validation | Ophthalmology Research | AAV Gene Therapy | RNA-based Therapy | Cell Therapy | Assay Development | iPSC | CRISPR | Oncology | Hearing Loss | CRO | Cricketer

Exciting work! Researchers have identified that alterations in AKT2 disrupt lysosome function in the retina, leading to drusen deposits, a hallmark of dry AMD (non-neovascular). This dysfunction, observed in both patient iPSC-derived RPE cells and mice models, results in RPE degeneration and drusen formation. ***The findings suggest that targeting the AKT2/SIRT5/TFEB pathway could be a potential therapy for dry AMD, a major cause of vision loss in the United States***. Worth reading: https://lnkd.in/ejdh4PUs

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