International Society of Organoid Research (ISoOR)’s Post

#CustomerPublicationWeekly #macrophages in #liver play important roles in liver diseases such as metabolic dysfunction-associated steatotic liver diseases and/or steatohepatitis (#MASLD/#MASH). In a study published this week in Immunity, researchers use #singlecell sequencing to reveal Notch signaling as a critical regulator of macrophage-mediated inflammation in those diseases. Singleron‘s GEXSCOPE Single Cell RNA Library Kit was used in this study. https://lnkd.in/eg-qEatC

Research suggests that 50 to 80 percent of people who recover from COVID-19 experience at least some lingering after-effects 3 months after infection with the coronavirus. Since the COVID-19 pandemic began there have been many studies conducted that aim to determine safety and explore efficacy of umbilical cord mesenchymal stem cell (UC‐MSC) infusions in subjects with COVID‐19. Mesenchymal stem cells administered intravenously may be able to significantly reduce significant adverse reactions, mortality, and time to recovery, in COVID-19 patients. #covidrecovery #stemcells #stemcelltherapy

New episode alert! We gave an overview today of the rationale behind using stem cell-based therapies to treat retinal disease. All digested using simple terms, go check it out! Eyes On Research https://lnkd.in/gCBQsUac

OPCs: REGENERATIVE AND IMMUNOMODULANT ROLE In addition to a “regenerative” role, oligodendrocyte progenitor cells (OPCs) also have an “immunomodulatory” role, particularly important in the context of multiple sclerosis (MS). Even today, a very few data exists to clarify the interactions between these two functions - intrinsic "regenerative" and "immune" - of OPCs, as well as their relationship with the inflamed environment of the central nervous system (CNS), a key factor in the pathology of SM. Here, the authors (Adi Vaknin-Dembinsky et al.) examined the effects of proinflammatory cytokines, represented by interferon (IFN)-γ and tumor necrosis factor (TNF)-α, as well as anti-inflammatory cytokines, represented by interleukin (IL)-4 and IL-10, on differentiation OPC and immune characteristics. What they observed is that a pro-regenerative and permissive inflammatory environment is required for OPCs to perform both regenerative and immunomodulatory function. The findings in an open access article on Immunology: https://lnkd.in/dZVvyqSz

Interesting concept to reverse aging of the immune system. Wider applications to modulate the immune system up or down to treat cancer or autoimmune diseases will be interesting too!!

Mesenchymal stem cells (MSCs) can be a promising tool in treating autoimmune diseases due to their unique characteristics. Here's how they can help: 1. **Immunomodulation**: MSCs have the capability to modulate immune responses. They can interact with various immune cells, like T cells, B cells, and dendritic cells, influencing their function and proliferation. This interaction can help reduce the overactive immune response typical in autoimmune diseases. 2. **Anti-inflammatory Effects**: MSCs can release anti-inflammatory molecules that help reduce inflammation, which is a common feature of autoimmune conditions. This can help alleviate symptoms and potentially lead to remission in certain diseases. 3. **Tissue Repair and Regeneration**: MSCs have the potential to differentiate into various types of cells, which can be useful for repairing tissues damaged by autoimmune attacks. This regenerative capability can help restore function to affected organs and tissues. 4. **Low Immunogenicity**: MSCs are generally considered "immune privileged," meaning they can be administered without the need for strict donor-recipient matching. This reduces the risk of rejection and enhances their suitability as a therapeutic option. #autoimmunedisease #autoimmune #autoimmunedisorder #mesenchymalstemcells #stemcells #exosometherapy #RegenerativeMedicine #regenerativetherapy

Looking forward to participating in a panel discussion about cGVHD with Pharmacy Times next week! It's a fascinating area with so much to unpack: the long-term effects, the various organ systems it can impact, and the ongoing research into treatment strategies. Let's dive deep and explore the intricacies of this challenging condition!

Interesting for aging research… By depletion of blood myeloid stem cells… Or more accurately shift the balance of differentiated cells…