JADBio AutoML’s Post

One of the best solutions for studies when you have a precious limited number of samples.

AlphaFold 3 is truly impressive tool for revealing functionality of natural processes. https://lnkd.in/dwWAJe2t

Convenient sample preparation for long read sequencing MIRO CANVAS is a digital microfluidics (DMF) platform that allows low throughput workflow automation for complex protocols, such as NGS library preparation. The system is compatible with a wide range of reagents. This application note describes the results that can be expected when using the SMRTbell Prep Kit 3.0 in a protocol developed for the MIRO CANVAS. The resulting research use only libraries can then be sequenced using the PacBio sequencing systems. Read here, how to automate PacBio SMRTbell WGS on MIRO CANVAS: https://bit.ly/49Q85yS #mirocanvas #pacbio #integrabiosciences

Our MIRO CANVAS platform continues to receive positive feedback from customers for its convenient sample preparation capabilities, especially for long read sequencing. Learn more about how MIRO CANVAS simplifies NGS library preparation with the SMRTbell Prep Kit 3.0 in our latest application note. #NGS #MIROCANVAS #CustomerFeedback #PacBio

The MIRO CANVAS NGS prep system automates complex NGS library preparation and hybridization protocols, such as long-read sequencing, target enrichment and on-demand processing of samples with only minutes of hands-on time. It utilizes novel digital microfluidics to move droplets using electromechanical forces and can automate mixing, PCR and bead cleanup steps. The compact device features an intuitive user interface and performs all the liquid handling steps within a single-use cartridge, reducing reagent usage by up to 75 %. Accelerate your genomics discoveries by automating your NGS workflows in one small device providing true walkaway use! https://lnkd.in/gMcdzDtD

The field of #proteomics has been profoundly impacted by the pioneering work of Dr. Steve Gygi’s lab at Harvard Medical School. The Gygi lab has developed a suite of powerful tools for analyzing large #MassSpectrometry datasets. Some of the key algorithms they’ve developed include: • Monocle: Accurate assignment of monoisotopic peaks, which is essential for correctly identifying peptides. • AScore: Probability of correct phosphorylation site localization, based on information about site-determining ions. •Smart-TMT: A collection of real-time spectral identification, data acquisition, visualization, and analysis tools. Watershed offers custom solutions for integrating these and other analysis tools into your research. Check out the Gygi lab’s website to explore their software in more detail, read the papers that introduce them, and try them out for yourself! https://lnkd.in/ecfRAjh5

ASHG hasn't even started yet, but the fun has! Earlier today, Illumina announced that our latest flow cell (the NovaSeq X Series 25B) has arrived! What can the genomics world do with this? I'm glad you asked! -Sequence 128 human genomes per run. 128! -Sequence those human genomes for $200. -Analyze the expression patterns of 1B to 2B cells at once. B as in Billion. -Screen massive numbers of cells for drug targets and drug target discovery. -Access sequencing-hungry methods such as ctDNA analysis more cost-effectively. -More economically approach multiomics, such as transcriptomics + epigenetics. -Sequence deeper. Or sequence more samples. Or both! -Leverage plug & play DRAGEN pipelines and variant calling directly onboard. Or choose the lower-output 10B and 1.5B flow cells if this is too much horsepower for you. Come check it out for yourself at ASHG. Booth 623.

Sign up to attend the Bitesize Bio webinar on MULTI-seq, an innovative scRNA-seq #multiplexing technology that maximizes sample #throughput while minimizing cost. Learn what MULTI-seq is, how to integrate MULTI-seq into #singlecell experiment workflows, and best practices for cell preparation and data analysis.

N of 1 studies can become pivotal in early discovery of biological signals. Longitudinal data & tools will be key to making this happen. Check out some of ImYoo's work on supporting patient scientists in their N of 1 intervention journey! Some data included ;) https://lnkd.in/gcfGZcre

Over the last few years we have been developing the confidence in using PBPK in the early drug discovery space, by validating HT-PBPK modelling approaches to be implemented in our pipeline and accelerate discovery efforts. In our latest work, our colleague Andrea Andrews-Morger together with Michael Reutlinger, Neil Parrott and myself illustrate the development of a Machine learning framework that can improve rat clearance predictions from hepatocyte data based on compound's structure that can be used in PBPK models.This work helps solving the issue of clearance miss-predictions that we observed in our previous works. Check it out in Molecular Pharmaceutics (https://lnkd.in/e7x-miSH) and also see our previous works in these aspects for rats https://lnkd.in/efEXFZWr) and humans (https://lnkd.in/ecGmKDxP)