Janardhan Boyapati’s Post

There is only one month to go until we come to Boston, US to hold our '6th Flow Chemistry & Continuous Processing Conference!' Our conference will feature two keynote presentations, panel discussions and networking opportunities, providing attendees with valuable insights into the latest developments in flow chemistry and continuous processing. The first Keynote Presentation will be delivered by Professor Tim Jamison from #MIT, USA. Tim will be discussing 'On-Demand Synthesis through the Lens of Flow Chemistry.' Professor C. Oliver Kappe and Dr Peter Sagmeister will be our second Keynote Speakers on Friday May 3 and they will be discussing 'The Rocky Road to a Digital (Flow Chemistry) Lab'. Peter has shared this abstract with us below;- 'Continuous manufacturing technology and digitalization are going to have a strong impact on how active pharmaceutical ingredients (APIs) are manufactured in the future. The development of smart manufacturing routes can be accelerated by utilizing digitalization, process analytical technology (PAT), and modeling from an early stage. Automated flow chemistry platforms equipped with real-time process analytics facilitate self-optimization, automated reaction model building, dynamic experiments, and the implementation of process control strategies. Furthermore, the adoption of modular slug flow reactors enables a reduction in materials required for optimization campaigns. The integration of data-driven workflows and advanced modeling techniques facilitates not only a deeper understanding and optimization of chemical processes but also significant time and resource savings within the pharmaceutical industry.' Please visit our brand new website to view the Full Program and how to register at https://lnkd.in/ePspr8GZ #FlowNA24 #FlowChemistry #GoFlow #CCFLOW #ContinousProcessing #CDMO #Networking #Pharma #OrganicChemistry #ProcessChemistry

Please come see us at Booth 950! Learn how our Crystallization and Reaction Screening solutions can help you succeed in your research!

Particle size impacts the pharmacokinetics of pharmaceutical compounds. The use of a polarized light microscope (PLM) to evaluate particle size helps solid-state chemists consider: 🔹 Particle shape and surface-area-to-volume ratio 🔹 Particle size’s impact on dissolution rate 🔹 Necessity of mechanisms to control particle size This episode of Crystal Classroom discusses particle size with Subject Matter Expert, Derik McCarthy. Subscribe to the Crystal Classroom series on YouTube as we look towards Part 2 of Crystal Classroom. In Part 2, we will explore topics surrounding thermogravimetric analysis (TGA). https://lnkd.in/ewztEF_W #CrystalPharmatech #CrystalClassroom #PLM #Chemistry #PharmaceuticalScience #CMC #Biotech #DrugDevelopment #Research #Technology #API #CRO #CDMO

Jason Dutton, David Wilson and Sarah Wengryniuk's team have just published a great paper on a new method for direct C-H amination of heteroarenes! (and here's a cover design to go with it!) Their method simplifies the process of adding nitrogen atoms to specific positions on ring structures, key components in many pharmaceutical compounds. Here are some key findings from the research: ⏣ Uses an iodine-based reagent to add nitrogen to specific sites on heteroarenes, without the need for pre-oxidation or additional preparation steps. ⏣ Allows direct amination at both the C2 and C4 positions, providing greater flexibility in the creation of complex nitrogen-containing compounds. ⏣ Efficient, operates under mild conditions and produces high yields of desired products. For anyone in the chemical and pharmaceutical industries, this is a significant step forward in the development of new compounds! Co-authors: Bill Motsch and Amelia H. Quach #sciart ⌬ #research ⌬ #chemistry

This year's AIChE® Annual Meeting puts an emphasis on how chemical engineers, across all disciplines, are shaping the world with their novel contributions. The theme for 2024 is Chemical Engineering Reimagined. This is your opportunity to continue the momentum by showcasing how your expertise can make an impact. Abstract Submission Deadline: April 8 - https://lnkd.in/eRaa3pw8 #AIChEAnnual #AnnualMeeting #Bioengineering #ChemicalEngineering #Pharmaceuticals #Catalysis #ProcessEngineering #MaterialsScience

Discover Bis(Di-Tert-Butyl(4-Dimethylaminophenyl)Phosphine) Dichloropalladium (II), a valuable catalyst in #chemicalsynthesis. With its unique structure and reactivity, this compound plays a crucial role in various #organictransformations. This catalyst enables the formation of carbon-carbon and carbon-heteroatom bonds, making it an indispensable tool for chemists. Its high catalytic activity and selectivity contribute to the efficient synthesis of complex organic molecules, particularly in pharmaceutical and #finechemical industries. Bis(Di-Tert-Butyl(4-Dimethylaminophenyl)Phosphine) Dichloropalladium (II) opens up new avenues for chemists to explore and discover novel synthetic methodologies. Join us as we continue to unravel the practical applications of this remarkable compound! #Chemistry #ChemicalCompound #Biochemical #ResearchChemistry #chemicals https://buff.ly/3Fr5GwZ

In early 2022, Xuchen joined Bellen Chemistry, he is responsible for overseeing the research and development of photochemistry processes. A primary objective is the transition of laboratory-scale photochemistry techniques into a photo-flow chemistry setting, thereby enhancing efficiency and scalability. Furthermore, Xuchen leads a dedicated team responsible for process development and manufacturing activities. Their efforts ensure the seamless integration of innovative chemical processes into manufacturing protocols, thereby facilitating the realization of Bellen's collaborative ventures. For more information about our photochemistry services, please contact us at customer-service@bellenchem.com #photochemistry #researchanddevelopment #CRO #researchanddevelopment #pharmaceutical #processdevelopment #bellenchem #smallmolecules #drugdiscovery #preclinicalresearch #chemistryservices #customsynthesis #medicinalchemistry #biotech #API #scaleup #FTE #chemistry

"The past couple of decades have seen a nearly exponential growth in the number of new therapeutic agents that have their origin in pharmaceutical biotechnology. Because many of these agents are not stable in aqueous solution, about half of them are freeze-dried. Freeze-drying is a fairly complicated process involving physical chemistry, heat and mass transfer, materials characterization, process modeling, and analytical chemistry. The Freeze Drying: Principles and Practice online course is for individuals who want to develop the necessary expertise to contribute to this very important field," says Dr. Steve Nail. Discover more about the complexities and advancements in freeze-drying technology through this new online course! https://lnkd.in/g5Eb-W4i

In the petrochemical industry and pharmaceutical industry, Fourier Transform Infrared (FTIR) Spectrometers are widely used in organic synthesis, polymer science, petrochemical engineering, food analysis, and pharmaceutical research. It serves both quantitative analytical method and determining bonding mechanisms in solids and on surfaces. Additionally, this equipment is widely employed to address food authenticity and detect food adulteration issues, providing accurate results. #labequipment #labtesting #pentasflora

Advancing pharmaceutical development with particle analysis The CCDC - The Cambridge Crystallographic Data Centre) has unveiled advanced informatics tools to enhance pharmaceutical and fine chemical manufacturing. These tools offer digital methods to improve product formulation efficiency and reduce costs. The report "Surface Analysis - From Crystal Structures to Particle Properties" highlights the suite's ability to visualise and quantify data, aiding formulators in reducing trial-and-error methods. A case study on ibuprofen particles demonstrated significant cost-saving potential. A study in Crystal Growth & Design introduced a geometry-based procedure to identify slip systems in molecular crystals, improving the design of energetic materials. Another study in Powder Diffraction explored the surface properties of a novel quercetin solvate, validating findings with Atomic Force Microscopy. These innovations mark a leap forward in understanding particle surfaces, benefiting drug development, agrochemicals, and advanced materials. Developed with industry leaders like AstraZeneca and Pfizer, CSD-Particle tools embody a ‘digital first’ approach for efficient pharmaceutical development. #Pharmaceuticals #ParticleAnalysis #CCDC #DrugDevelopment #Chemistry https://lnkd.in/eTwD546m