Jason du Preez’s Post

For all working in Bioanalysis

https://lnkd.in/eVu5Bdiz, https://lnkd.in/e_fbrqii   Embarking on a profound journey within the realm of medicinal chemistry, I am driven by a deep passion to make a meaningful impact, particularly in addressing neglected tropical diseases (NTDs). For this commitment, I collaborate with the LPCR team at Aix-Marseille Université (France), working synergistically with our esteemed partners from the LBqT team at FIOCRUZ (Brazil). The invaluable financial support extended by MinCiencias - Colombia plays a pivotal role in propelling our shared goals forward. I take immense pride in actively contributing to the collective efforts aimed at combating NTDs. This collaborative endeavor extends beyond the laboratory, encompassing a multifaceted approach involving not only scientific research but also strategic partnerships. In sharing our research outcomes, I am eager to communicate both the anticipated successes and the lessons drawn from challenges, recognizing that every aspect contributes to our collective growth. My current focus revolves around advancing research for new treatments in leishmaniasis, a pursuit that involves navigating both the anticipated and less glamorous facets of the scientific journey. I remain excited about the prospect of shaping the future landscape of medicinal chemistry and contributing to a world where neglected tropical diseases are no longer overlooked.

Join our symposium at ECIO 2024: The new Pearls of TACE The new Pearls of TACE Moderators: Prof. P. Pereira and Dr. G. Verset  Agenda >Evolving role of TACE in HCC  >BioPearl™: The first resorbable drug eluting microspheres >Advantages of feeding artery reperfusion  >The BIOPEARL-ONE study  >Panel discussion

That’s easy ICI Bioscience LLC! This is an infographic that shows the 7 major leading manufacturers of #personalcareproducts and the more than 187 brands they produce. In no particular order they are: Johnson & Johnson Procter & Gamble Coty The Estée Lauder Companies Inc. / Estée Lauder L'Oréal Unilever Shiseido Myself, my friends, and family all use and #trust many of these #brands for our daily personal care activities such as washing, moisturizing, styling, treating boo boos, and on our #babies as they have problems or issues that need some help. We turn to these #trustedbrands to keep us clean, healthy and looking great! But what does any of this have to do with MJ Unpacked April 9, 10, 11 in Atlantic City ICI Bioscience LLC ? Why are you asking me such ridiculous questions!?

Looking to explore the science behind SubMagna™ HMW? Check out this informative podcast that discusses how this innovative base can effectively carry high molecular weight molecules like Semaglutide, as well as other combinations such as hormones, low dose naltrexone, sildenafil, tadalafil, and sumatriptan. As someone with experience in this field, I can confidently say that SubMagna™ HMW is the superior choice for GLP-1 medications delivered in a compounded sublingual format. Don't miss out on this valuable resource! Send us a message if you are looking like a solution like this for your patients. #subsema #submagna

Join us Sep. 26 where we discuss the start-to-finish bulk RNA-Seq analysis process, including what it is, why you do it, and considerations you need to make. Details and registration: https://lnkd.in/gYAkDDFn #RNA #bioinformatics

Bioquochem (BQC redox technologies) will participate in the upcoming IUFOST2024ITALY (September 8-12, 2024 | Rimini, Italy). We are excited to announce that Sara Menéndez Cotarelo will be delivering an insightful talk on Bioactive Compound Rapid Screening (#BRS): A Versatile and Promising #Analytical Technique for #Quantifying #Bioactive #Compounds in Diverse #Hydrophilic and #Lipophilic Matrices. On September 10th, there is a brief discussion in the exhibition area, and then we will delve deeper into the topic during the session on september 12th. 📍Speech | September 12: 10/11 am in Borgo Room 📍BOOTH 52 #Key points to be covered: Overview of Bioactive Compound Screening  Applications in hydrophilic and lipophilic matrices Advantages of BRS over traditional methods Case studies and practical examples and on-site #BRS demos. See you there!

This week I read Gilles Ouvry’s insightful post on azetidine amides. (If you’re a med chemist, Gilles Ouvry is a MUST-follow for his brilliant med chem insights and infographics). He points out that azetidine amides are unique because they can have a different SAR than other tertiary amides due to their unique torsional profile. For example - when a benzamide nitrogen is N,N-disubstituted, steric effects twist the amide out of plane with the benazmide. Azetidine amides instead tend to behave more like mono-substituted amides while not having an N-H donor. (See Gilles' write-up here: https://lnkd.in/gxerU_Qj) With the Drug Hunter substructure search, I was surprised to find numerous examples of azetidine amides being applied in clinical candidates through Ph. III, even though there’s only one approved drug with this motif (cobimetinib). You can request a demo of Drug Hunter and the Structure Search feature at the link below: https://lnkd.in/gSK-zSwV

UPDATED POSTER: Phytocannabinoid Guide: Biosynthesis, Naming, & Numbering: Download PDF or request a physical copy ► https://loom.ly/5imMME0 This lab wall poster presents the biosynthesis and degradation pathways of phytocannabinoids derived from the olivetol, varinol, and orcinol series and explains the conventions that have been adopted for nomenclature and structure numbering systems.