How do you integrate new, largely clinically untested, therapeutic technology platforms with deep biological, clinical, regulatory, marketing, and distribution in highly specific diseases? Today, etherna announces ( https://lnkd.in/eHEzbEcn) one approach to this problem by partnering with Almirali, a leader in dermatology in order to usher in a new generation of mRNA drugs for skin diseases. This capitalizes on the synergy between state of the art custom LNP-mRNA capabilities (etherna) and world class knowledge and execution capabilities in an important organ system. Other partnerships are soon to follow.
Many technology platform companies are caught between two worlds, having to optimize a clinically unproven technology platform, deliver this optimized platform to partners, and then to identify/execute/fund internal programs towards a specific drug target or disease, often without the depth of biological/clinical/regulatory/marketing know-how in this specific area. As a result, poor choices are made for the internal candidate and the outcome of the platform companies becomes an open question. Such has been the fate of many platform companies currently, and why they are falling out of favor at this moment. This has been the conundrum also for companies moving from mRNA vaccines (where the path is clear) to mRNA therapeutics where there are many options but where POC in the clinic is yet to be fully achieved.
Now that I am formally retired from academia ( https://lnkd.in/eekppGWm), I am hoping to use my deep knowledge and biological intuition in the of CV/metabolic/renal diseases to work with partners, including etherna, to enhance the development of a new generation of mRNA drugs. Looking forward to future interactions with my many colleagues in the biotechnology arena going forward.
We are proud to announce our partnership with Almirall in the development of mRNA based therapies in medical dermatology. We will combine the leading expertise of Almirall with our innovative proprietary mRNA capabilities and LNP formulations. Together we will advance skin disease treatments.
Want to know more?
https://lnkd.in/ebQFUsM2
#innovation #mRNA #partnership