Jason Kim, PhD’s Post

Today we presented positive data from a Phase 2 clinical trial of ESK-001, a highly selective allosteric TYK2 inhibitor, for the treatment of plaque #psoriasis at the American Academy of Dermatology Annual Meeting. Learn more: https://lnkd.in/e9pKPCBM #AAD2024

New Publication in Dermatology and Therapy: The analysis of an IL-13 inhibitor across EASI body regions and clinical signs of Atopic Dermatitis, results from ADvocate 1 & ADvocate 2 trials. View the full publication here: https://e.lilly/4ayAaKR

We eagerly await the results of this pivotal clinical trial of dupilumab I designed together with dermatology colleagues Pascal Joly, Victoria Werth and Arsalan Shabbir for bullous pemphigoid. Here is the trial rationale and design. https://lnkd.in/gs5tZbcd

Experts in dermatology provide a comprehensive year in review regarding the management of plaque psoriasis, highlighting key therapeutic approvals from 2023. The discussion will highlight pivotal clinical studies supporting these approvals and our discussion will then pivot to have a special focus on addressing the unique challenges faced by treating patients with skin of color and treatment access barriers. Explore the series here: https://ow.ly/az7y50RSCnx

Learn how we source and underwrite assets to maximize our investors' returns while minimizing downside risk at Florida Dermatology and Skin Cancer Center. Read our comprehensive case study, here ➡️ https://bit.ly/48xvgxW

I am privileged to share our new article published in the American Journal of Clinical Dermatology, which focuses on the use of topical calcineurin inhibitors on atopic dermatitis patients among the Taiwanese population. Please feel free to discuss and share your comments with me! https://lnkd.in/gYnFpfMh #atopicdermatitis #cohortstudy #topicalcalcineurininhibitors #NationalHealthinsuranceResearchDatabase

Different clinicopathologically defined #nevus subtypes have different degrees of cytological atypia and different risk of association with #melanoma.

Learn how we source and underwrite assets to maximize our investors' returns while minimizing downside risk at Florida Dermatology and Skin Cancer Center. Read our comprehensive case study, here ➡️ https://bit.ly/48xvgxW

How do you integrate new, largely clinically untested, therapeutic technology platforms with deep biological, clinical, regulatory, marketing, and distribution in highly specific diseases? Today, etherna announces ( https://lnkd.in/eHEzbEcn) one approach to this problem by partnering with Almirali, a leader in dermatology in order to usher in a new generation of mRNA drugs for skin diseases. This capitalizes on the synergy between state of the art custom LNP-mRNA capabilities (etherna) and world class knowledge and execution capabilities in an important organ system. Other partnerships are soon to follow. Many technology platform companies are caught between two worlds, having to optimize a clinically unproven technology platform, deliver this optimized platform to partners, and then to identify/execute/fund internal programs towards a specific drug target or disease, often without the depth of biological/clinical/regulatory/marketing know-how in this specific area. As a result, poor choices are made for the internal candidate and the outcome of the platform companies becomes an open question. Such has been the fate of many platform companies currently, and why they are falling out of favor at this moment. This has been the conundrum also for companies moving from mRNA vaccines (where the path is clear) to mRNA therapeutics where there are many options but where POC in the clinic is yet to be fully achieved. Now that I am formally retired from academia ( https://lnkd.in/eekppGWm), I am hoping to use my deep knowledge and biological intuition in the of CV/metabolic/renal diseases to work with partners, including etherna, to enhance the development of a new generation of mRNA drugs. Looking forward to future interactions with my many colleagues in the biotechnology arena going forward.

Want to learn more about our AtopicDermatitis registry. Let’s schedule a meeting and discuss how we can support your dermatology development initiatives. #rwe #rwd #registry #atopicdermatitis