Jes Lindholt’s Post

Excited to see the cover story in Vascular News is highlighting our recent open access systematic review and metaanalysis on the potential repurposing of drugs to treat AAA medically by PhD students Joachim Sejr Skovbo Kristensen, Mads Liisberg, Lytfi Krasniqi, Lasse Obel,  Egle Kavaliunaite and I (https://lnkd.in/dDUFsE9t). What a job they did: Of a total of 7,484 screened studies, 39 were included and 12 drug groups underwent meta-analyses. Metformin and statins were statistically significant in slowing AAA growth - even after exclusion of high bias risk studies by -0.73mm/year regarding metformin and -0.84mm/year regarding statins.  However with high levels of heterogeneity. Better studies are needed. Fortunately 4 RCTs on Metformin is upcoming, but RCTs on statins will probably never be performed of ethical reasons. To provide the highest achievable evidence level to convince those not prescribing it to all AAA patients, we need to stick to robust pharmacoepidemiologic studies as we did when we demonstrated that statins reduced the risk of rupture by 25% and 30d postoperative mortalit by 20% ( https://lnkd.in/d3pP-GBd).  

Vascular News 101 – February 2024: European Edition - Vascular News

Vascular News 101 – February 2024: European Edition - Vascular News

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