JHEP Reports’ Post

Meet Giuseppe Indolfi, previous chair of the Hepatology Committee! Watch to learn more about the activities of the Hepatology committee and their Special Interest Groups working to improve PGHAN practice! 🔽 #WeAreESPGHAN

Fundamental work for a better definition of the role of #SIRT in combination with #systemictherapy as first-line approach for patients with liver-only unresectable #iCCA #Editorial at Hepatology 79(1):p 9-11, January 2024. | DOI: 10.1097/HEP.0000000000000561 Julien Edeline Irene Bargellini #GianlucaMasi

New paper out (pre-proof version for now)! While I’m happy this one got published in Clinical Gastroenterology and Hepatology, it got rejected in some journals with higher impact factors first. Unfortunately, most editors are not too keen on publishing negative results or failed interventions. I’m not blaming them for it, although there is a lot to learn from failure. One of the key messages in this paper is that standardizing faecal microbiota transplants based on the amount of faeces used to prepare FMTs doesn’t really make sense (since bacterial load varies substantially between stools, even on a day-to-day basis in one person). Standardizing based on cell counts (as we did) is better – doing it based on the number of live cells is recommended. Spreading this message by sharing my post would be highly appreciated! Thanks to my co-authors Clara Caenepeel, Sara Deleu, Jorge Francisco Vázquez Castellanos, Kaline Arnauts, Sara Braekeleire, Kathleen Machiels, Filip Baert, Fazia Mana, Lieven Pouillon, Pieter Hindryckx, Triana Lobaton, Edouard Louis, Denis Franchimont, Bram Verstockt, Marc Ferrante, João Sabino, Sara Vieira-Silva, Jeroen Raes, and Séverine Vermeire for the nice collaboration! Credits to Duygu Koldere Vilain for the graphical abstract. https://lnkd.in/eiqmB9CC

🌟 Hepatology Review Opportunity! 🌈 Passionate about liver health? Join our Narrative Review project! 🔍 Explore hepatology topics deeply. 👉 Express Interest: Comment your enthusiasm and hepatology experience. 📌 Follow for updates and more opportunities. 📝 Application: Visit our LinkedIn and DM us from right upper corner 3 dots and click on message 🚀 Contribute to liver health understanding with us! 🌟 Stay tuned for updates and more chances! #HepatologyReview #ResearchOpportunity 🚀

We’re thrilled to announce our newest paper in #FrontlineGastroenterology is now published online. "From O’Shaughnessy to Opportunity: Innovating #HepatologyTrials in the UK" The review explores the challenges and opportunities in conducting clinical trials for #liverdisease, particularly decompensated #cirrhosis, within the UK. Working in collaboration with Oliver Tavabie, Gautam Mehta, Daniel Green and other experts, we reflect on historical achievements, current obstacles, and future directions to enhance hepatology clinical trial performance, emphasising the necessity of innovative approaches post-COVID-19 pandemic. The review draws on insights from the #OShaughnessy report and the UK-Chronic Liver Failure network (UK-CLIF), highlighting key areas for improvement and collaboration. Highlights from the report: ➡ Recommendations from the O’Shaughnessy Report ➡ Addressing Representation and Diversity ➡ Connecting Stakeholders and Standardising Care ➡ Innovating Trial Design and Delivery ➡ Enhancing Clinical Trial Career Pathways ➡ Developing the Commercial Hepatology Trials Sector To read the full review head to the PHARMExcel website 👉 https://lnkd.in/dkg42TwU #Heptology #ClinicalTrials #Gastroenterology #LiverDisease #FrontlineGastroenterology

We cordially extend an invitation to researchers from all around the globe to submit their research work for publishing in our Global Journal Of Gastroenterology & Hepatology Research. To know more, visit here: https://lnkd.in/gtiuQCiG WhatsApp Us: +447723493307 #Colonoscopy #LiverHealth #Hepatology #Gallbladder #Pancreas #CeliacDisease #GIResearch #GutMicrobiome #GutHealth #NutritionAndGut #FODMAPs #DigestiveDisorders #StomachHealth Show less

I am interested in the potential benefits of precision medicine in managing inflammatory bowel disease (IBD). I had the privilege of presenting on this topic at a two-day congress organized by the Iranian Association of Gastroenterology and Hepatology held in Mashhad in March 2024. I would like to express my gratitude to Dr. Beheshti, the scientific secretary of the congress, for giving me this opportunity. Precision medicine involves customizing treatments based on the unique characteristics of each patient, including their genetics, microbiome, immune system, and environmental factors, and precision medicine can provide more effective and individualized therapies that can improve the quality of life and outcomes for patients with IBD. #IBD #precisionmedicine #gastroenterology

📣 We are thrilled to announce our participation in the leading Spanish Hepatology Congress, by Asociación Española del Estudio del Hígado, where we have presented an original scientific poster.  🆕 This new research is the result of our R&D team, focused on developing an improved culture model using human precision-cut liver slices (hPCLS) to investigate the phenotype and functionality of the hepatic sinusoid in the context of chronic liver disease. By using our patent-protected chip with microfluidics, we are able to culture hPCLS with: ✔ Extended half-life, up to 7 days. ✔ Enhanced structural and functional integrity of the tissue. ✔ Prevention of the loss of the sinusoidal cell phenotype. This model represents a new research tool that brings us closer to clinical applications compared to traditional models 🚀  #AEEH2024 #Liver #Sinusoid #Hepatology #Cirrhosis #ACLD #PCLS #3Dmodel #Scientificinnovation

Excellent course on #NAFLD or so called #MASLD (according to the recent change in the nomenclature, see the latest number of the Journal of Hepatology 🧬): my mentors Prof. Roberto Vettor , Prof. Paolo Angeli and Dr. Silvia Bettini did wonderful lectures enlightening the deep links between #obesity, #metabolic illnesses and #liverdisease. The use of #Fibroscan appears to be of growing interest for the staging and diagnosis of #steatohepatitis and #liverfibrosis of different aetiologies. Echosens Novo Nordisk

Pathophysiology of policystic liver disease