Jingcheng Zhao, MD PhD’s Post

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Medical Affairs, Novo Nordisk | Karolinska Institutet & Danish Cancer Institute

Excited to share our latest paper, published today in JAMA. We show evidence of possible transmission of a factor causing intracerebral hemorrhages through blood transfusion. Using nationwide registers and blood bank data in Sweden and Denmark, we show that among approximately 1M patients who underwent transfusions, the risk of an intracerebral hemorrhage increases approximately from 1.5% to almost 4% over 30 years among patients transfused with blood from blood donors that later developed multiple intracerebral hemorrhages - compared to blood from donors that did not develop intracerebral hemorrhages. This exploratory study was based on the biological premise that cerebral amyloid angiopathy (CAA), a disease characterized by beta-amyloid deposition in brain blood vessels and the second most common cause of intracerebral hemorrhage, may be transmissible. Previous studies have shown that CAA can be transferrable in humans through the injection of contaminated cadaveric pituitary hormone and dura mater grafts. Intracerebral hemorrhage was a very rare event and we do not currently see a need for a policy change nor do we wish to discourage otherwise indicated blood transfusion. However, more research is needed to explore the possible underlying mechanisms. Thanks to Principal Investigator Gustaf Edgren, and our collaborators, especially Klaus Rostgaard and Henrik Hjalgrim who replicated the analyses in Denmark. Links in the comments below.

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Charlotte Myrup

MD, PhD, Senior Consultant at the Departement of Paediatrics in Rigshospitalet

1y

Interessant! Kunne sammenhængen også ses som en følge af overførsel af autoinflammatoriske stoffer via blodet, som vi kender det mellem mor og foster?

Klaus Rostgaard

Senior Statistician at Kræftens Bekæmpelse (Danish Cancer Society)

1y

Yes, very fine comment by F. Perry Wilson. And thank you very much Jing for battling with JAMA all the way to success.

Adrian Boström

MD, PhD in Medicine, BSc Business & Economics | ST-Läkare/Resident Doctor in Child- and Adolescent Psychiatry

1y

Great to run into you the other day and congratulations on this impressive achievement 👏

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Eric Thelin

Neurology Trainee/Resident (ST-läkare) at Karolinska University Hospital, Research Group Leader and Associate Professor (Docent) at Karolinska Institutet

1y

Sjukt intressant, bra jobbat!

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Joachim Werr

Founder of Health Navigator (HN), co-founder of Utfallsfonden, Co-opted Board Member Doctors without borders, Sweden. MD, PhD, Ex-McKinsey, Ex-NHS Innovation Accelerator fellow.

1y

Very impressive and another example of the power of data. No clinical study even needed, “just” proper statistical analysis driven by a smart hypothesis. Congratulations!

Mikael Hoffmann

CEO of the NEPI foundation, Chairman of the Committee for Pharmaceutical Policy på The Swedish Society of Medicine

1y

Great to see the article finally in print and accompanied by a fine editorial! Congratulations to the team.

Robert Khashan

Research scholar @ Harvard Medical School & Boston Children's Hospital | MD student @ University of Gothenburg

1y

Väldigt intressanta resultat! Stort grattis!

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Soran Rabin Bozorg

Resident Gastroenterologist | PhD Candidate in Epidemiology and Health Economics

1y

Great study, congratulations!

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