Jnana Therapeutics’ Post

It has been many years since I was co-first author on a paper again. My latest paper was just published on iScience with Cell Press. This work was done at Northwestern University. It's a collaborative, humongous, 53-page paper on toxoplasmosis. I was the one who first screened the library of compounds in the Silverman lab on the enzyme TgO/GABA-AT and discovered many compounds that act as inhibitors or inactivators. The followed collaborative work showed that these compounds can potentially influence merozoite’s capacity to make gametes that fuse to become zygotes, which contaminate environments and cause the disease. Hopefully, this paper will make the discovery of therapeutics toward toxoplasmosis become closer to reality. https://lnkd.in/ehH-JiHR

Insights into Aging: A Cellular Perspective Explore the interplay of genetics and cellular mechanisms in aging through our latest blog. Marin Biologic Laboratories delves into current research and cell-based assay applications in anti-aging drug discovery. Dive into this detailed exploration here:  https://bit.ly/3SfohDJ #AgingResearch #CellularMechanisms #BiotechInsight

🔬 Exciting breakthrough! 🌱 Aptamers developed for #RNase inactivation in Xtract-Free™ sample collection medium. 🧬 Dr. Luke Daum, Mr. John D. Rodriguez, and Prof. James Chambers's widely-read preprint addresses need for eco-friendly sample collection, vital for point-of-care and home testing. 💡 Using SELEX technology, they created anti-RNase DNA aptamers, preserving genetic material. 💬 How might these innovative aptamers transform the landscape of sample collection and genetic testing? Read and share your thoughts! https://lnkd.in/gYHeRVc7 #SampleCollection #Biotechnology #GenomicAnalysis

Our team at the #UMNPDC has developed a sensitive chemical assay to detect and quantify gyromitrin, a toxic compound found in false morel mushrooms. In a recent paper published in eNeurologicalSci. We collaborated with # Prof.Spencer at Oregon Health & Science University, et al. studying a cluster of amyotrophic lateral sclerosis (ALS) cases linked to the consumption of false morels in the French Alps. Using our assay, we: Corrected the initial misidentification of the mushrooms as the less toxic Gyromitra gigas species. Confirmed they were the more toxic G. venenata and G. esculenta containing high gyromitrin levels. Showed that most ALS patients had a slow-acetylator genotype, increasing susceptibility to gyromitrin toxicity. Our gyromitrin detection method provides a valuable tool for monitoring this neurotoxic compound and advancing research into environmental triggers of neurodegenerative diseases like ALS. We're proud of this interdisciplinary collaboration combining mycology, analytical chemistry, genetics, and clinical neurology to shed light on this tragic cluster of ALS cases. University of Michigan College of Pharmacy University of Michigan U-M Biosciences Initiative #ALS #Gyromitrin #FalseMorel #Fungi #NaturalProducts #mushrooms #umich #UMLifeSciencesInstitute #UMMedChem

Explore how automated liquid handling drives innovation in synthetic biology (gene synthesis and protein engineering) with precision technology. Read the full blog here: https://lnkd.in/e5-7BtHg #IDOT #Technology #Automation #LifeSciences #LiquidHandling #LabAutomation #Development #DrugDiscovery #Genomics #SyntheticBiology #LaboratoryAutomation #FutureOfHealth

A cryptic plasmid unique to the human gut with a prevalence greater than 90% in some countries. Monoclonal in individuals and enriched under (oxidative) stress conditions as in #inflammatoryboweldisease. A lot of biology to uncover ... #microbiome #microbiota #ulcerativecolitis https://lnkd.in/efHQMKYh

Explore how automated liquid handling drives innovation in synthetic biology (gene synthesis and protein engineering) with precision technology. Read the full blog here: https://lnkd.in/eYd3ei97 #IDOT #Technology #Automation #LifeSciences #LiquidHandling #LabAutomation #Development #DrugDiscovery #Genomics #SyntheticBiology #LaboratoryAutomation #FutureOfHealth

A team of scientists from CSIR-IGIB and the L.V. Prasad Eye Institute has developed an advanced genome-editing system that improves upon existing CRISPR technologies by increasing precision and efficiency. CRISPR-Cas9, the revolutionary gene-editing tool, allows us to modify DNA with incredible accuracy. However, off-target effects have been a challenge—until now. The researchers engineered a new version of the Cas9 enzyme, derived from Francisella novicida bacteria, known as FnCas9. This enhanced FnCas9 has shown remarkable improvements: 🔹 Higher precision in targeting specific DNA sequences. 🔹 Reduced off-target effects. 🔹 Increased efficiency in editing genes, including those related to inherited diseases like Leber congenital amaurosis type 2, a form of blindness. Check out the full document for more details on this groundbreaking work . #GenomeEditing #CRISPR #Biotechnology #Genetics #ResearchInnovation #Healthcare #ScienceAdvancements #CSIRIGIB #LVPrasadEyeInstitute CSIR-IGIB

Working on iPSCs? Did you know that 30% of cultures are affected by genetic instability? Don´t overlook iPSC health, or risk unreliable data and failed experiments. On June 12th, we host our webinar, discussing essential quality control measures for iPSCs, aligned with ISSCR standards. Learn how genomic stability assessments can address iPSC health and how to monitor your cells during outgrowth. Ensure the reliability and reproducibility of your iPSC research with cutting-edge solutions by Cellected Limited and Advanced Instruments, LLC. #QualityControl #DrugDevelopment #CellTherapy #Genomics #iPSCs #CellLineDevelopment #StemCellResearch #Biotechnology #LabTech #AdvancedTherapeutics

Are hidden genetic changes sabotaging your iPSC research? 😥 Many scientists overlook iPSC health, risking unreliable data and failed experiments. Join our exclusive webinar on June 12th to uncover essential quality control measures for iPSCs, aligned with ISSCR standards. - Discover how genomic stability assessments can reveal and address the 30% of cultures affected by genetic changes. - Our experts Claire Richards and Marta Rucka, PhD will introduce Cellected Ltd.'s RESCUE solution, combining high-throughput single-cell cloning and advanced genomic screening to recover pristine cell lines. Ensure the reliability and reproducibility of your iPSC research with cutting-edge solutions. Take control of your iPSC health! Register now to transform your culture practices: https://lnkd.in/eij8VqeW #QualityControl #DrugDevelopment #CellTherapy #Genomics #iPSCs #CellLineDevelopment #StemCellResearch #Biotechnology #LabTech #AdvancedTherapeutics https://lnkd.in/eaugn4Zm