1. **Study Overview**: A year-long trial investigated the effects of liraglutide, a drug for weight loss and diabetes, on cognitive decline in individuals with mild Alzheimer’s disease. 2. **Results**: Participants receiving liraglutide showed an 18% reduction in cognitive decline compared to those given a placebo. 3. **Expert Opinions**: Neurologist Alberto Espay noted the potential of the drug to become a groundbreaking treatment if results are replicated in larger trials. 4. **Need for Further Research**: Experts emphasize that larger studies are necessary to confirm these preliminary findings, which contribute to the exploration of diabetes and weight loss medications for Alzheimer’s treatment. 5. **Mechanism of Action**: GLP-1 agonists, like liraglutide, may reduce amyloid protein levels in the brain, which are associated with Alzheimer’s. 6.Funding and Future Trials**: The study was partially funded by Novo Nordisk, which sells liraglutide. Ongoing larger trials are investigating other GLP-1 agonists, like semaglutide, in treating Alzheimer’s. 7.Significance**: If proven effective, liraglutide could significantly change the treatment landscape for Alzheimer’s disease due to its safety profile and potential efficacy.
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In January 2024, a new clinical study was published in Nature’s Journal of Translational Medicine. It is titled “Tirzepatide prevents neurodegeneration through multiple molecular pathways”. Several pieces of evidence have demonstrated that glucagon-like peptide 1 receptor agonists (GLP1-RAs) reduce the risk of dementia in type 2 diabetes patients by improving memory, learning, and overcoming cognitive impairment. Likewise, in 2019, researchers in China and Taiwan published a study in the Journal of Parkinson's Disease investigating semaglutide and liraglutide in mice with conditions similar to Parkinson’s. They found that both drugs improved movement problems and protected brain cells. Semaglutide seemed to work better than liraglutide (GLP-1 receptor agonists). They decided to conduct a clinical study to investigate the neuroprotective effects of semaglutide. Scientists and clinicians have recognized the intimate connection between metabolic and mental well-being for centuries, echoing ancient wisdom. Insights from drug repurposing, like the unexpected benefits of Viagra for treating impotence after heart disease patients, have spurred scientists to explore novel applications and different use cases for existing medications. In this discussion, I aim to highlight two widely used glucagon-like peptide 1 receptor agonists, Tirzepatide and Semaglutide, to make my points. These drugs have the potential to affect the nervous, digestive, and immune systems positively. Their neuroprotective and anti-inflammatory properties make them promising candidates for repurposing in these areas. To better understand their potential, I want to explain the functions and mechanisms of glucagon-like peptide-1 across the body, including its impact on the brain. What is glucagon-like peptide-1? https://lnkd.in/g6VJK8bJ
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I News & Insights Exciting developments in Alzheimer's research! A new study presented at the AAIC suggests that Novo's GLP-1 drug liraglutide, known for treating diabetes and obesity, may also slow cognitive decline in Alzheimer's disease. The study found significant brain-protective effects, with nearly 50% less brain volume loss in key regions. Although further research is needed, this could be a promising step forward in the fight against Alzheimer's. At Akshar Global Clinical Research (AGCR) we are closely following these advancements that have the potential to change lives #AlzheimersResearch #ClinicalTrials #Neuroprotection #PharmaInnovation #AGCR #ClinicalResearch #CRO #ahmedabad
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