John Roulac’s Post

Who knew that Boron is of of the most important minerals on the periodic table ? For soil, food and human health. What is the leading cause of shortage of Boron ? Use of synthetic fertilzers reduces Boron levels in soil and thus our food : The trace mineral boron is a micronutrient with diverse and vitally important roles in metabolism that render it necessary for plant, animal, and human health, and as recent research suggests, possibly for the evolution of life on Earth. As the current article shows, boron has been proven to be an important trace mineral because it (1) is essential for the growth and maintenance of bone; (2) greatly improves wound healing; (3) beneficially impacts the body’s use of estrogen, testosterone, and vitamin D; (4) boosts magnesium absorption; (5) reduces levels of inflammatory biomarkers, such as high-sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor μ (TNF-μ); (6) raises levels of antioxidant enzymes, such as superoxide dismutase (SOD), catalase, and glutathione peroxidase; (7) protects against pesticide-induced oxidative stress and heavy-metal toxicity; (8) improves the brains electrical activity, cognitive performance, and short-term memory for elders; (9) influences the formation and activity of key biomolecules, such as S-adenosyl methionine (SAM-e) and nicotinamide adenine dinucleotide (NAD+); (10) has demonstrated preventive and therapeutic effects in a number of cancers, such as prostate, cervical, and lung cancers, and multiple and non-Hodgkin’s lymphoma... https://lnkd.in/gW8rGWxF.

Science News from research organizations Hepatic disease: A camu-camu fruit extract to reduce liver fat Date: August 21, 2024 Source: Université Laval A research team from Université Laval has shown the benefits of camu-camu on non-alcoholic fatty liver disease, which affects over seven million people in Canada. This exotic fruit reduces liver fat levels. Over 12 weeks, thirty participants took either camu-camu extract or a placebo at different times in this randomized clinical trial. Participants underwent magnetic resonance imaging (MRI) to determine fat levels in the liver. https://lnkd.in/gfNz7r3D

Engineered probiotic ameliorates ulcerative colitis by restoring gut microbiota and redox homeostasis 🌟 Research Highlights 🌟 🔍 Data mining has revealed significant alterations in Lactobacillus levels and oxidative stress in UC patients. 🦠 Researchers engineered Lactobacillus casei to incorporate selenium dots within a pericellular film, enhancing its protective capabilities. 🧬 Upon oral administration, Se-fLac demonstrated synergistic effects by scavenging reactive oxygen species (ROS) and modulating gut microbiota. 🐭 The therapeutic efficacy of Se-fLac was confirmed in multiple mouse models and non-human primates (NHPs). Summary: Probiotics have potential therapeutic benefits for ulcerative colitis (UC), but their effectiveness is often compromised by gastrointestinal challenges. This study utilized machine learning and bioinformatics to identify decreased Lactobacillus levels and increased oxidative stress in UC patients, which correlated with inflammation severity. To address this, the team developed an innovative approach by engineering Lactobacillus casei with a pericellular film embedded with ultrasmall selenium dots (Se-Lac), which enhanced gastric resistance and mucoadhesion. At the inflammation site, Se-fLac scavenged ROS and modulated the microbiota, effectively reducing colonic damage in both animal models and NHPs. These findings suggest that Se-fLac could be a promising treatment for UC, restoring intestinal redox balance and microbiota homeostasis. https://lnkd.in/g4UvqDxX #UlcerativeColitis #Probiotics #Microbiome #OxidativeStress #Biotechnology #ResearchInnovation #GutHealth

🔬 New Research Unveils Gut Microbiota's Role in Diabetic Nephropathy Risk In a recent study, researchers have uncovered potential causal links between specific gut microbiota compositions and the risk of developing diabetic nephropathy (DN), a major diabetic complication. 🌐 Study Insights Utilizing data from the largest genome-wide association study (GWAS) aggregated by the MiBioGen consortium and DN data from the IEU database, the study employed the inverse-variance weighting (IVW) method to explore these associations. Key findings include: Protective Microbiota: Genus Dialister shows a strong protective correlation against DN. Similar protective effects were observed in classes Gammaproteobacteria and Lentisphaeria, and phylum Proteobacteria. Risks Associated with Certain Microbiota: Conversely, genus LachnospiraceaeUCG008, order Bacteroidales, and genus Terrisporobacter were found to increase the risk of developing DN. 💡 This study not only establishes a causal relationship between the genus Dialister and a reduced risk of DN but also highlights the need for further clinical trials. These trials will aim to confirm the protective effects of probiotics containing these beneficial bacteria and elucidate the mechanisms behind their protective properties. #diabetes #microbiomeresearch #clinicaltrials https://lnkd.in/dQMDGyyb

BONE HEALTH VIA “gut-immune axis" MODULATION In recent years, there has been a worrying increase in the incidence of bone diseases globally. Ankylosing spondylitis, osteoporosis, rheumatoid arthritis, osteoarthritis, and fractures alone impact an estimated 1.71 billion people worldwide. The term “gut microbiota” (GM) refers to the diverse population of microorganisms that live in the gut, including bacteria, fungi, viruses, protozoa, and archaea. GM has a mutualistic relationship with the host organism and is essential in preserving gut health. The host's gastrointestinal tract provides a nutrient-rich environment, which is one of the main drivers of this mutualistic relationship. The gut microbiota (GM) plays a crucial role in interacting with the host through the synthesis of a wide range of metabolites called gut-associated metabolites (GAMs), which originate from external dietary substrates or endogenous host compounds. Many metabolic disorders have been linked to alterations in the activity and composition of the gut microbiota. The development of metabolic diseases has been linked to certain microbiota-derived metabolites, such as branched-chain amino acids (BCAAs), bile acids (BA), short-chain fatty acids(SCFAs), tryptophan, trimethylamine N-oxide (TMAO), polyamines and indole derivatives. Modulation of the gut microbiota by biotics (pre-, pro-, and post-biotics) presents a promising avenue for therapeutic intervention. Biotics selectively promote the growth of beneficial gut bacteria, thereby enhancing the production of GAMs with potential beneficial effects on bone metabolism. S. Yadav, L. Sapra, and R.K. Srivastava have just published a review in Int J Biol Macromolecules, titled Polysaccharides to postbiotics: Nurturing bone health via modulating “gut-immune axis", where they report on the relationship between the synthesis of several gut metabolites, GAMs, and potential benefits on bone metabolism. #BoneDiseases #BoneMetabolism #Biotics #GAM https://lnkd.in/dEgmQ7A3

☑️ *READ ABSTRACT BELOW:* Background: Infantile cholestasis (IC) is the most common hepatobiliary disease in infants, resulting in elevated direct bilirubin levels. Indeed, hepatointestinal circulation impacts bile acid and bilirubin metabolism. This study evaluates changes in the gut microbiota composition in children with IC and identifies abnormal metabolite profiles associated with microbial alterations. Results: The gut microbiota in the IC group exhibits the higher abundance of Veillonella, Streptococcus and Clostridium spp. (P < 0.05), compared to healthy infants (CON) group. Moreover, the abundance of Ruminococcus, Vibrio butyricum, Eubacterium coprostanogenes group, Intestinibacter, and Faecalibacterium were lower (P < 0.05). In terms of microbiota-derived metabolites, the levels of fatty acids (palmitoleic, α-linolenic, arachidonic, and linoleic) (P < 0.05) increased and the levels of amino acids decreased in IC group. Furthermore, the abundances of Ruminococcus, Eubacterium coprostanoligenes group, Intestinibacter and Butyrivibrio are positively correlated with proline, asparagine and aspartic acid, but negatively correlated with the α-linolenic acid, linoleic acid, palmitoleic acid and arachidonic acid. For analysis of the relationship between the microbiota and clinical index, it was found that the abundance of Veillonella and Streptococcus was positively correlated with serum bile acid content (P < 0.05), while APTT, PT and INR were negatively correlated with Faecalibalum and Ruminococcus (P < 0.05). Conclusion: Microbiota dysbiosis happened in IC children, which also can lead to the abnormal metabolism, thus obstructing the absorption of enteral nutrition and aggravating liver cell damage. Veillonella, Ruminococcus and Butyrivibrio may be important microbiome related with IC and need further research. Jin M, BMC Microbiol. 2023 Nov 18;23(1):357. doi: 10.1186/s12866-023-03115-1. PMID: 37980506; PMCID: PMC10656868. #Gesundheit #Bildung #Fuehrung #Coaching #Mindset #Motivation #Gehirn #Neuroscience #Psychologie #Persoenlichkeitsentwicklung #Kindheit #KeyNoteSpeaker #Humangenetik #Biochemie #Neuroleadership #Ernaehrung #Transformation #Stress #Demografie #Gender #Age #interkulturelleKompetenz #Epigenetik #Veraenderung #EmotionaleIntelligenz #Change #Gesellschaft #Organisationsentwicklung #Philosophie #Beratung # Quantum

🌿Power of Polyphenols in Urolithiasis Treatment and Prevention! Scientists at Huazhong University of Science and Technology have published a comprehensive review on the potential of dietary polyphenols in the treatment and prevention of urolithiasis, a common urological disease with high recurrence rates. The review highlights the antioxidant potential of polyphenols in combating reactive oxygen species (ROS) and oxidative stress (OS), which are crucial pathogenic factors in stone formation. Dietary polyphenols, found in plant-based foods and beverages, have been shown to scavenge free radicals and ROS, modulate enzyme expression and activity, regulate signaling pathways, and maintain cell morphology and function. Stay tuned to #PolyphenolsApplications2024 for more updates on the latest research and developments in the field of polyphenols and their health benefits. Read more about this review: https://lnkd.in/dc4YZcvX. #PolyphenolsWorldCongress #PolyphenolsApplications #polyphenols #antioxidants #oxidativestress #reactiveoxygenspecies #urology #urolithiasis

An Interesting Insight on Probiotics and Osteoporosis 👇

Just Published! Hydrophilic Vitamins in Health and Disease edited by Anureet K. Shah, Paramjit Tappia & Naranjan S. Dhalla Read here: https://lnkd.in/eMX9YNzF This edited volume covers the most important aspects of hydrophilic vitamins. Vitamins are involved in a wide range of biological processes and cell function and are considered as essential nutrients. The essential nature of vitamins as well as their unique biochemistry, molecular mechanisms and cellular function in health and disease are emphasized in this book which will serve as a highly useful resource for health professionals, nutritional scientists, medical students, fellows, residents, and graduate students. Enjoy! #Biochemistry #VitaminB #VitaminC #Metabolism #Nutrition #CellBiology #CardiovascularDisease #Skin #Neurodegeneration #Bone #Inflammation #Cancer #Tuberculosis #Books Springer Nature Group

Understanding Ceruloplasmin: Key Insights Ceruloplasmin is a protein produced by the liver that plays a crucial role in the body's metabolism and transport of copper. Here's a detailed look at what ceruloplasmin is and why it's important: What is Ceruloplasmin? Ceruloplasmin is an enzyme that binds to copper and carries it throughout the body. It is responsible for transporting more than 95% of the copper found in blood plasma¹². Copper is essential for various bodily functions, including the development of vital organs, the formation of new blood vessels, and the maintenance of bone health². Functions of Ceruloplasmin: 1. Copper Transport: Ceruloplasmin helps distribute copper to different parts of the body, ensuring that this vital mineral is available where needed¹. 2. Iron Metabolism: It plays a role in oxidizing ferrous iron (Fe²⁺) to ferric iron (Fe³⁺), which is necessary for iron transport and storage³. 3. Antioxidant Activity: Ceruloplasmin has antioxidant properties, helping to protect cells from damage caused by free radicals¹. Why is a Ceruloplasmin Test Important? A ceruloplasmin test measures the level of this protein in your blood and can help diagnose several conditions: - Wilson Disease: This genetic disorder prevents the body from properly transporting and eliminating copper, leading to copper buildup in organs. Low ceruloplasmin levels are a key indicator of Wilson disease¹². - Copper Deficiency : Conditions such as malnutrition, malabsorption, or Menkes disease can lead to low ceruloplasmin levels, indicating a deficiency in copper¹. - Liver Disease: Since ceruloplasmin is produced in the liver, its levels can reflect liver function and health². Symptoms Indicating the Need for a Ceruloplasmin Test: - Abdominal pain - Anemia - Difficulty walking or swallowing - Nausea - Tremors - Jaundice (yellowish skin or eyes) - Fatigue - Osteoporosis - Tingling or numbness in hands or feet¹² Conclusion: Monitoring ceruloplasmin levels is essential for diagnosing and managing conditions related to copper metabolism and liver function. Understanding this protein's role can help in early detection and treatment of related health issues. #Ceruloplasmin #CopperMetabolism #WilsonDisease #LiverHealth #MedicalTesting #Healthcare #Biochemistry Source: (1) Ceruloplasmin Test: Purpose, Procedure & Results - Cleveland Clinic. https://lnkd.in/dCfedpYv. (2) Low Ceruloplasmin: What it is and How to Know if You Have It - WebMD. https://lnkd.in/dWf_Ceki. (3) Ceruloplasmin - Definition, Test and Function - Biology Dictionary. https://lnkd.in/dWuFmxgB. (4) Ceruloplasmin (Blood) - University of Rochester Medical Center. https://lnkd.in/djZPDmss. (5) en.wikipedia.org. https://lnkd.in/d_Bc8WY6.