How to predict decompensation and mortality in patients with alcohol-related liver disease (ALD)? Patients with ALD face significant risks of disease progression and adverse outcomes. Liver stiffness measurement (LSM) is recommended for prognostication and monitoring. This study, shows that LSM is useful for ALD prognosis. Elevated baseline LSM (>10 kPa) was linked to a 19-fold increased risk of decompensation. LSM changes over two years correlated with decompensation and death, with higher LSM indicating worse outcomes. #OpenAccess here: https://lnkd.in/dQmv4c8a Maja Thiele Aleksander Krag EASL | The Home of Hepatology
Journal of Hepatology ’s Post
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𝐂𝐨𝐦𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧𝐬 𝐨𝐟 𝐅𝐚𝐭𝐭𝐲 𝐋𝐢𝐯𝐞𝐫 𝐃𝐢𝐬𝐞𝐚𝐬𝐞 Fatty liver disease, if left untreated, can lead to serious health complications. Awareness of these potential outcomes is essential for proactive management and prevention. 𝘕𝘰𝘯-𝘈𝘭𝘤𝘰𝘩𝘰𝘭𝘪𝘤 𝘚𝘵𝘦𝘢𝘵𝘰𝘩𝘦𝘱𝘢𝘵𝘪𝘵𝘪𝘴 (𝘕𝘈𝘚𝘏): A more severe form of fatty liver disease characterized by liver inflammation and damage. 𝘓𝘪𝘷𝘦𝘳 𝘍𝘪𝘣𝘳𝘰𝘴𝘪𝘴: Scarring of the liver tissue which can impede liver function. 𝘊𝘪𝘳𝘳𝘩𝘰𝘴𝘪𝘴: Advanced scarring that can lead to liver failure, a life-threatening condition. 𝘓𝘪𝘷𝘦𝘳 𝘊𝘢𝘯𝘤𝘦𝘳: Increased risk of hepatocellular carcinoma, a primary liver cancer. 𝘊𝘢𝘳𝘥𝘪𝘰𝘷𝘢𝘴𝘤𝘶𝘭𝘢𝘳 𝘋𝘪𝘴𝘦𝘢𝘴𝘦: Fatty liver disease is associated with a higher risk of heart disease and stroke. Managing fatty liver disease involves addressing the underlying risk factors and making lifestyle changes to prevent these serious complications. Regular monitoring and early intervention can make a significant difference in outcomes. #FattyLiverDisease #LiverHealth #ChronicDisease #HealthComplications #NASH #Cirrhosis #PreventiveCare
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Primary Biliary Cholangitis (PBC) is a chronic cholestatic liver disease characterized by the destruction of small- to medium-sized intrahepatic bile ducts, leading to cholestasis, fibrosis, and potentially cirrhosis and liver failure. This condition predominantly affects middle-aged women, with a female-to-male ratio of approximately 9:1. Despite its relative rarity, PBC is a significant cause of morbidity and mortality among liver diseases. via The National Institutes of Health #PBCawareness #LiverHealth https://lnkd.in/gquJ5Cqz
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Translational Science Lead at AstraZeneca | Immunology | Cell Therapy | Oncology | Precision Medicine | Biomarker Discovery
Vascular damage in systemic lupus erythematosus The authors review the cellular and molecular mechanisms that drive vascular injury in Systemic lupus erythematosus (SLE) and discuss current and future treatment approaches to cardiovascular disease in SLE. - SLE is associated with an increased risk of developing cardiovascular disease (CVD), which is a leading cause of morbidity and mortality. - The increased risk of CVD in these patients is driven by profound immune dysfunction and compounded by corticosteroid treatment and traditional risk factors. - IFN-I and neutrophil dysregulated pathways have particularly damaging effects on the vasculature in SLE. - Although management of SLE has improved, patients often have unacceptably high disease activity and medications that improve vascular outcomes are desperately needed. - Improved understanding of the pathophysiology of vascular damage in SLE may lead to improved characterization of pathways of CVD development in the general population as well as personalized therapeutic approaches for this potentially devastating complication. https://lnkd.in/eXTkYYW4 #autoimmunedisease #lupus #autoimmunity #cardiovasculardisease
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Understanding the pivotal regulatory roles of healthy abdominal fatty tissue in signal transduction may answer the question: how can abundant visceral fat deposition lead to serious, life-threatening diseases
Obesity, insulin resistance and cancer are associated with defective estrogen signaling.
growkudos.com
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Understanding the pivotal regulatory roles of healthy abdominal fatty tissue in signal transduction may answer the question: how can abundant visceral fat deposition lead to serious, life-threatening diseases
Obesity, insulin resistance and cancer are associated with defective estrogen signaling.
growkudos.com
-
Understanding the pivotal regulatory roles of healthy abdominal fatty tissue in signal transduction may answer the question: how can abundant visceral fat deposition lead to serious, life-threatening diseases,
Obesity, insulin resistance and cancer are associated with defective estrogen signaling.
growkudos.com
-
Understanding the pivotal regulatory roles of healthy abdominal fatty tissue in signal transduction may answer the question: how can abundant visceral fat deposition lead to serious, life-threatening diseases,
Obesity, insulin resistance and cancer are associated with defective estrogen signaling.
growkudos.com
-
Understanding the pivotal regulatory roles of healthy abdominal fatty tissue in signal transduction may answer the question: how can abundant visceral fat deposition lead to serious, life-threatening diseases
Obesity, insulin resistance and cancer are associated with defective estrogen signaling.
growkudos.com
-
Review of excessive and persistent NETosis, wreaking havoc within the systemic circulation. A holy grail for potential targeted treatment. This aggregated extracellular chromatin contains a high content of polycationic histones with a very high affinity for polyanionic heparin. Excessive cytotoxic extracellular histones can be removed by blood purification, improving circulatory perfusion and minimizing the risk of intravascular microthrombi and development of macrothrombosis. Reviewed by Yayasli: "It has been reported that aggNETs-driven occlusions play a role in the pathogenesis of many diseases not only in vessels but also in ducts [6,7]. Vascular occlusions containing aggNETs are found in alveolar capillaries of patients with COVID-19".
Neutrophil Extracellular Trap-Driven Occlusive Diseases
ncbi.nlm.nih.gov
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Understanding the pivotal regulatory roles of healthy abdominal fatty tissue in signal transduction may answer the question: how can abundant visceral fat deposition lead to serious, life-threatening diseases, such as cardiovascular lesions and malignancies
Obesity, insulin resistance and cancer are associated with defective estrogen signaling.
growkudos.com
Chief Medical Officer | Clinical Development
1moVery useful data. It intuitively makes sense as LSM indicates degree of fibrosis, which in turn is the key prognostic factor for liver related complications and outcomes. Hence use of LSM (and platelet) by Baveno guidelines to diagnose and manage portal hypertension.