Jose Vicente Cardona’s Post

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Group Director Oncology, Global Medical Affairs at Roche

#cancerimmunotherapy for early-stage #NSCLC: when, what and to whom? ◾ The integration of cancer immunotherapy in managing early-stage NSCLC has shown promising results, backed by numerous positive clinical trials in recent years. ◾ Several #treatmentstrategies can be employed for patients with resectable NSCLC: #neoadjuvant, #adjuvant, and #perioperative treatments. However, the absence of direct comparative studies among these strategies makes it difficult to determine the added benefits of one over the others. ◾ Although neoadjuvant treatment offers several hypothetical advantages, such as reducing #tumorsize and inducing a sustained antitumor #immuneresponse, it also carries potential risks like precluding #surgery due to disease #progression or #toxicity. Conversely, post-operative treatment disposition is usually lower and patients might miss out on adjuvant therapy that could improve their #prognosis. ◾ Therefore, selecting a particular strategy depends on various factors, including #patient and #tumor characteristics, #patientpreferences, institutional #experience, local drug #reimbursement policies, and the availability of approved ICI-based regimens. The #multidisciplinarytumorboard plays a pivotal role in this decision-making process. 🔗 https://lnkd.in/eNpFhVbB

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